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Xbp1 X box binding protein-1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44226, updated on 17-Dec-2024

Summary

Official Symbol
Xbp1provided by FlyBase
Official Full Name
X box binding protein-1provided by FlyBase
Primary source
FLYBASE:FBgn0021872
Locus tag
Dmel_CG9415
See related
AllianceGenome:FB:FBgn0021872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
138/3; anon-EST:Liang-1.41; CG 9415; CG9415; clone 1.41; DM18; Dmel\CG9415; dmXBP1; dXbp-1; Dxbp-1; l(2)k13803; sXbp1; xbp-1; Xbp-1; XBP-1; xbp1; XBP1; XbpI
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; intestinal stem cell homeostasis; and regulation of protein metabolic process. Predicted to be active in nucleus. Is expressed in several structures, including adult antennal olfactory receptor neurons; amnioserosa primordium; epithelium; gut section; and mesoderm. Orthologous to human XBP1 (X-box binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Xbp1 in Genome Data Viewer
Location:
57C3-57C4; 2-93 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21143545..21145750)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17031050..17033255)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene mago nashi Neighboring gene magi Neighboring gene uncharacterized protein Neighboring gene High mobility group protein 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response PubMed 
involved_in IRE1-mediated unfolded protein response PubMed 
involved_in IRE1-mediated unfolded protein response PubMed 
involved_in endoplasmic reticulum unfolded protein response PubMed 
involved_in intestinal stem cell homeostasis PubMed 
involved_in intestinal stem cell homeostasis PubMed 
involved_in negative regulation of organ growth PubMed 
involved_in positive regulation of proteasomal protein catabolic process PubMed 
involved_in positive regulation of transcription by RNA polymerase II PubMed 
involved_in regulation of DNA-templated transcription  
involved_in regulation of axon regeneration PubMed 
involved_in regulation of translation in response to endoplasmic reticulum stress PubMed 
involved_in response to endoplasmic reticulum stress PubMed 
involved_in response to endoplasmic reticulum stress PubMed 
involved_in response to endoplasmic reticulum stress PubMed 
involved_in response to endoplasmic reticulum stress PubMed 
involved_in triglyceride mobilization PubMed 
Component Evidence Code Pubs
is_active_in nucleus  
located_in nucleus  

General protein information

Preferred Names
X box binding protein-1
Names
CG9415-PD
CG9415-PE
X box binding protein 1
X-box binding protein
X-box protein 1
X-box-binding protein 1
Xbp1-PD
Xbp1-PE
NP_726032.4
  • unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21143545..21145750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166427.4 → NP_726032.4  X box binding protein-1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726032.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MLW7
    Conserved Domains (2) summary
    cd14691
    Location:81 → 138
    bZIP_XBP1; Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a DNA-binding and dimerization domain
    cl09111
    Location:114 → 167
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  2. NM_079983.4 → NP_524722.2  X box binding protein-1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524722.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5BI44
    Related
    FBpp0301745
    Conserved Domains (1) summary
    cd14691
    Location:81 → 138
    bZIP_XBP1; Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a DNA-binding and dimerization domain
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