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    top1a DNA topoisomerase Ia [ Danio rerio (zebrafish) ]

    Gene ID: 553496, updated on 9-Dec-2024

    Summary

    Official Symbol
    top1aprovided by ZNC
    Official Full Name
    DNA topoisomerase Iaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060616-217
    See related
    Ensembl:ENSDARG00000070545 AllianceGenome:ZFIN:ZDB-GENE-060616-217
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    top1l; wu:fc66a02; zgc:136349
    Summary
    Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA replication; DNA topological change; and chromosome segregation. Predicted to act upstream of or within rhythmic process. Predicted to be located in chromosome and nucleus. Predicted to be active in nucleolus. Orthologous to human TOP1 (DNA topoisomerase I). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See top1a in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (25296366..25311680)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (25058750..25074064)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene tumor protein p53 inducible nuclear protein 2 Neighboring gene cylindromatosis (turban tumor syndrome) 2 Neighboring gene zinc fingers and homeoboxes 3a Neighboring gene family with sequence similarity 83 member D

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in DNA replication  
    involved_in DNA topological change  
    acts_upstream_of_or_within DNA topological change  
    involved_in chromosome segregation  
    acts_upstream_of_or_within rhythmic process  
    Component Evidence Code Pubs
    located_in chromosome  
    is_active_in nucleolus  
    located_in nucleus  

    General protein information

    Preferred Names
    DNA topoisomerase I, like
    Names
    topoisomerase (DNA) I, like
    NP_001037789.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044324.2NP_001037789.1  DNA topoisomerase I, like

      See identical proteins and their annotated locations for NP_001037789.1

      Status: VALIDATED

      Source sequence(s)
      BC050952, BC117588, CR548630
      UniProtKB/TrEMBL
      A0A8M1N957, Q1ED17
      Related
      ENSDARP00000065948.6, ENSDART00000065949.8
      Conserved Domains (4) summary
      smart00435
      Location:353730
      TOPEUc; DNA Topoisomerase I (eukaryota)
      pfam01028
      Location:425628
      Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
      pfam02919
      Location:208422
      Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
      pfam14370
      Location:688756
      Topo_C_assoc; C-terminal topoisomerase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      25296366..25311680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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