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ELOF1 elongation factor 1 [ Homo sapiens (human) ]

Gene ID: 84337, updated on 10-Dec-2024

Summary

Official Symbol
ELOF1provided by HGNC
Official Full Name
elongation factor 1provided by HGNC
Primary source
HGNC:HGNC:28691
See related
Ensembl:ENSG00000130165 MIM:619818; AllianceGenome:HGNC:28691
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ELF1
Summary
Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in transcription elongation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in testis (RPKM 39.1), prostate (RPKM 12.1) and 25 other tissues See more
Orthologs
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Genomic context

See ELOF1 in Genome Data Viewer
Location:
19p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11553046..11559230, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11680553..11686741, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11663861..11670045, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ECSIT signaling integrator Neighboring gene ribosomal protein S12 pseudogene 32 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11648637-11649582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14022 Neighboring gene calponin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11662408-11663379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14024 Neighboring gene Sharpr-MPRA regulatory region 7075 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14025 Neighboring gene uncharacterized LOC124904638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11687946-11688558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11688559-11689170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14027 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11692934-11693099 Neighboring gene acid phosphatase 5, tartrate resistant Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14029 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 76

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II complex binding  
enables metal ion binding  
enables protein binding PubMed 
Component Evidence Code Pubs
part_of transcription elongation factor complex  

General protein information

Preferred Names
transcription elongation factor 1 homolog
Names
ELF1 homolog, elongation factor 1
elongation factor 1 homolog (ELF1, S. cerevisiae)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363673.3NP_001350602.2  transcription elongation factor 1 homolog

    Status: VALIDATED

    Source sequence(s)
    AC008481
    Consensus CDS
    CCDS12264.1
    UniProtKB/Swiss-Prot
    P60002, Q8R1J7, Q96II4
    UniProtKB/TrEMBL
    K7EPC8
    Related
    ENSP00000465765.2, ENST00000587806.5
    Conserved Domains (1) summary
    pfam05129
    Location:2080
    Elf1; Transcription elongation factor Elf1 like
  2. NM_001363674.4NP_001350603.2  transcription elongation factor 1 homolog

    Status: VALIDATED

    Source sequence(s)
    AC008481, AC009001
    Consensus CDS
    CCDS12264.1
    UniProtKB/Swiss-Prot
    P60002, Q8R1J7, Q96II4
    UniProtKB/TrEMBL
    K7EPC8
    Conserved Domains (1) summary
    pfam05129
    Location:2080
    Elf1; Transcription elongation factor Elf1 like
  3. NM_001363675.4NP_001350604.2  transcription elongation factor 1 homolog

    Status: VALIDATED

    Source sequence(s)
    AC008481, AC009001
    Consensus CDS
    CCDS12264.1
    UniProtKB/Swiss-Prot
    P60002, Q8R1J7, Q96II4
    UniProtKB/TrEMBL
    K7EPC8
    Conserved Domains (1) summary
    pfam05129
    Location:2080
    Elf1; Transcription elongation factor Elf1 like
  4. NM_032377.4NP_115753.1  transcription elongation factor 1 homolog

    See identical proteins and their annotated locations for NP_115753.1

    Status: VALIDATED

    Source sequence(s)
    AC008481, BG718042
    Consensus CDS
    CCDS12264.1
    UniProtKB/Swiss-Prot
    P60002, Q8R1J7, Q96II4
    UniProtKB/TrEMBL
    K7EPC8
    Related
    ENSP00000252445.3, ENST00000252445.8
    Conserved Domains (1) summary
    pfam05129
    Location:2080
    Elf1; Transcription elongation factor Elf1 like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    11553046..11559230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    11680553..11686741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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