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    NTNG1 netrin G1 [ Homo sapiens (human) ]

    Gene ID: 22854, updated on 10-Dec-2024

    Summary

    Official Symbol
    NTNG1provided by HGNC
    Official Full Name
    netrin G1provided by HGNC
    Primary source
    HGNC:HGNC:23319
    See related
    Ensembl:ENSG00000162631 MIM:608818; AllianceGenome:HGNC:23319
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Lmnt1; NetG1; NetrinG1
    Summary
    This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2015]
    Expression
    Broad expression in brain (RPKM 1.0), kidney (RPKM 0.9) and 14 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NTNG1 in Genome Data Viewer
    Location:
    1p13.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (107140088..107484923)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (107177595..107522472)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (107682710..108027545)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378888 Neighboring gene long intergenic non-protein coding RNA 1661 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1414 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1415 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:107683301-107683832 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1130 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:107707080-107708279 Neighboring gene protein arginine methyltransferase 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1131 Neighboring gene NANOG hESC enhancer GRCh37_chr1:107963104-107963605 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:107974475-107975331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1418 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1132 Neighboring gene NDUFA4 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1420 Neighboring gene vav guanine nucleotide exchange factor 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:108409832-108410528 Neighboring gene microRNA 7852

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA0976

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in axonogenesis  
    involved_in modulation of chemical synaptic transmission  
    involved_in regulation of neuron migration  
    involved_in regulation of neuron projection arborization  
    involved_in regulation of neuron projection development  
    involved_in synaptic membrane adhesion PubMed 
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse  
    located_in extracellular region  
    located_in glutamatergic synapse  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in presynaptic active zone membrane  
    located_in side of membrane  

    General protein information

    Preferred Names
    netrin-G1
    Names
    axon guidance molecule
    laminet 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042821.1 RefSeqGene

      Range
      6122..350006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001113226.3NP_001106697.1  netrin-G1 isoform G1a preproprotein

      See identical proteins and their annotated locations for NP_001106697.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (G1a).
      Source sequence(s)
      AC114491, AL513187, AL590427
      Consensus CDS
      CCDS44180.1
      UniProtKB/Swiss-Prot
      Q5VU86, Q5VU87, Q5VU89, Q5VU90, Q5VU91, Q7Z2Y3, Q8N633, Q9Y2I2
      Related
      ENSP00000359085.1, ENST00000370068.6
      Conserved Domains (3) summary
      smart00180
      Location:420467
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:296342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71295
      Laminin_N; Laminin N-terminal (Domain VI)
    2. NM_001113228.3NP_001106699.1  netrin-G1 isoform G1d precursor

      See identical proteins and their annotated locations for NP_001106699.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two exons and contains two alternate exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (G1d) is shorter than isoform a.
      Source sequence(s)
      AC114491, AL513187, AL590427
      Consensus CDS
      CCDS44179.1
      UniProtKB/TrEMBL
      X5DNW2
      Conserved Domains (3) summary
      cd00054
      Location:415439
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:296342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71295
      Laminin_N; Laminin N-terminal (Domain VI)
    3. NM_001312688.2NP_001299617.1  netrin-G1 isoform G1n precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an exon and contains an alternate exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (G1n) is shorter than isoform a.
      Source sequence(s)
      AC114491, AK025924, AK296533, AL513187
      UniProtKB/TrEMBL
      B4DKF0, E7EQM9
      Conserved Domains (4) summary
      smart00180
      Location:386433
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00054
      Location:440464
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:296342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71295
      Laminin_N; Laminin N-terminal (Domain VI)
    4. NM_001330665.2NP_001317594.1  netrin-G1 isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate in-frame exon and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform G1a.
      Source sequence(s)
      AC114491, AL513187, AL590427
      Consensus CDS
      CCDS81354.1
      UniProtKB/Swiss-Prot
      Q9Y2I2
      Related
      ENSP00000359084.1, ENST00000370067.5
      Conserved Domains (3) summary
      cd00054
      Location:395419
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:296342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71295
      Laminin_N; Laminin N-terminal (Domain VI)
    5. NM_001372166.1NP_001359095.1  netrin-G1 isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AC114491, AL513187, AL590427
      Conserved Domains (4) summary
      smart00180
      Location:364411
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00054
      Location:418442
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:296342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71295
      Laminin_N; Laminin N-terminal (Domain VI)
    6. NM_001372167.1NP_001359096.1  netrin-G1 isoform G1a preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC114491, AL513187, AL590427
      Consensus CDS
      CCDS44180.1
      UniProtKB/Swiss-Prot
      Q5VU86, Q5VU87, Q5VU89, Q5VU90, Q5VU91, Q7Z2Y3, Q8N633, Q9Y2I2
      Related
      ENSP00000359090.2, ENST00000370073.6
      Conserved Domains (3) summary
      smart00180
      Location:420467
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:296342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71295
      Laminin_N; Laminin N-terminal (Domain VI)
    7. NM_001372168.1NP_001359097.1  netrin-G1 isoform G1c precursor

      Status: REVIEWED

      Source sequence(s)
      AC114491, AL513187, AL590427
      Consensus CDS
      CCDS30785.1
      UniProtKB/TrEMBL
      B4DMW3
      Conserved Domains (3) summary
      cd00054
      Location:373397
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:296342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71295
      Laminin_N; Laminin N-terminal (Domain VI)
    8. NM_001372169.1NP_001359098.1  netrin-G1 isoform G1d precursor

      Status: REVIEWED

      Source sequence(s)
      AC114491, AL513187, AL590427
      Consensus CDS
      CCDS44179.1
      UniProtKB/TrEMBL
      X5DNW2
      Related
      ENSP00000359083.1, ENST00000370066.5
      Conserved Domains (3) summary
      cd00054
      Location:415439
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:296342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71295
      Laminin_N; Laminin N-terminal (Domain VI)
    9. NM_001372170.1NP_001359099.1  netrin-G1 isoform G1a preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC114491, AL513187, AL590427
      Consensus CDS
      CCDS44180.1
      UniProtKB/Swiss-Prot
      Q5VU86, Q5VU87, Q5VU89, Q5VU90, Q5VU91, Q7Z2Y3, Q8N633, Q9Y2I2
      Conserved Domains (3) summary
      smart00180
      Location:420467
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:296342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71295
      Laminin_N; Laminin N-terminal (Domain VI)
    10. NM_001372171.1NP_001359100.1  netrin-G1 isoform G1c precursor

      Status: REVIEWED

      Source sequence(s)
      AC114491, AL513187, AL590427
      Consensus CDS
      CCDS30785.1
      UniProtKB/TrEMBL
      B4DMW3
      Conserved Domains (3) summary
      cd00054
      Location:373397
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:296342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71295
      Laminin_N; Laminin N-terminal (Domain VI)
    11. NM_014917.4NP_055732.2  netrin-G1 isoform G1c precursor

      See identical proteins and their annotated locations for NP_055732.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a longer 5' UTR and lacks two exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (G1c) is shorter than isoform a.
      Source sequence(s)
      AC114491, AK025924, BC030220, DA195069
      Consensus CDS
      CCDS30785.1
      UniProtKB/TrEMBL
      B4DMW3
      Related
      ENSP00000359091.3, ENST00000370074.8
      Conserved Domains (3) summary
      cd00054
      Location:373397
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:296342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71295
      Laminin_N; Laminin N-terminal (Domain VI)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      107140088..107484923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000683.3XP_016856172.1  netrin-G1 isoform X3

      UniProtKB/TrEMBL
      X5DNW2
      Conserved Domains (3) summary
      cd00054
      Location:415439
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:296342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71295
      Laminin_N; Laminin N-terminal (Domain VI)
    2. XM_047449449.1XP_047305405.1  netrin-G1 isoform X4

    3. XM_047449447.1XP_047305403.1  netrin-G1 isoform X2

    4. XM_017000686.3XP_016856175.1  netrin-G1 isoform X6

      UniProtKB/Swiss-Prot
      Q9Y2I2
      Related
      ENST00000294649.8
      Conserved Domains (2) summary
      cd00055
      Location:296342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71295
      Laminin_N; Laminin N-terminal (Domain VI)
    5. XM_011541025.3XP_011539327.1  netrin-G1 isoform X5

      Conserved Domains (2) summary
      cd00055
      Location:296342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71295
      Laminin_N; Laminin N-terminal (Domain VI)
    6. XM_047449448.1XP_047305404.1  netrin-G1 isoform X2

    7. XM_047449446.1XP_047305402.1  netrin-G1 isoform X1

      UniProtKB/Swiss-Prot
      Q5VU86, Q5VU87, Q5VU89, Q5VU90, Q5VU91, Q7Z2Y3, Q8N633, Q9Y2I2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      107177595..107522472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335145.1XP_054191120.1  netrin-G1 isoform X3

      UniProtKB/TrEMBL
      X5DNW2
    2. XM_054335146.1XP_054191121.1  netrin-G1 isoform X4

    3. XM_054335143.1XP_054191118.1  netrin-G1 isoform X2

    4. XM_054335147.1XP_054191122.1  netrin-G1 isoform X5

    5. XM_054335144.1XP_054191119.1  netrin-G1 isoform X2

    6. XM_054335142.1XP_054191117.1  netrin-G1 isoform X1

      UniProtKB/Swiss-Prot
      Q5VU86, Q5VU87, Q5VU89, Q5VU90, Q5VU91, Q7Z2Y3, Q8N633, Q9Y2I2
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