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hecd-1 E3 ubiquitin-protein ligase;E3 ubiquitin-protein ligase hecd-1 [ Caenorhabditis elegans ]

Gene ID: 177486, updated on 9-Dec-2024

Summary

Official Symbol
hecd-1
Official Full Name
E3 ubiquitin-protein ligase;E3 ubiquitin-protein ligase hecd-1
Primary source
WormBase:WBGene00016405
Locus tag
CELE_C34D4.14
See related
AllianceGenome:WB:WBGene00016405
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin protein ligase activity. Involved in several processes, including determination of adult lifespan; hemidesmosome assembly; and regulation of Notch signaling pathway. Predicted to be active in nuclear speck. Orthologous to human HECTD1 (HECT domain E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See hecd-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
22
Sequence:
Chromosome: IV; NC_003282.8 (7134346..7144720, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Peptidyl-prolyl cis-trans isomerase Neighboring gene Biogenesis of lysosome-related organelles complex 1 subunit 5 Neighboring gene putative Golgi apparatus membrane protein-like protein C34D4.4 Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene MSP domain-containing protein

Bibliography

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding  
enables transferase activity  
enables ubiquitin protein ligase activity  
enables ubiquitin protein ligase activity  
enables ubiquitin-protein transferase activity  
Process Evidence Code Pubs
involved_in determination of adult lifespan PubMed 
involved_in hemidesmosome assembly PubMed 
involved_in negative regulation of Notch signaling pathway PubMed 
involved_in positive regulation of Notch signaling pathway PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process PubMed 
involved_in protein polyubiquitination  
involved_in protein ubiquitination  
involved_in regulation of cell fate specification PubMed 
involved_in regulation of germ cell proliferation PubMed 
involved_in regulation of response to oxidative stress PubMed 
involved_in regulation of vulval development PubMed 
involved_in ubiquitin-dependent protein catabolic process  
Component Evidence Code Pubs
is_active_in nuclear speck  

General protein information

Preferred Names
E3 ubiquitin-protein ligase;E3 ubiquitin-protein ligase hecd-1
NP_001293688.1
  • Confirmed by transcript evidence
NP_001293689.1
  • Confirmed by transcript evidence
NP_001293691.1
  • Confirmed by transcript evidence
NP_001368363.1
  • Confirmed by transcript evidence
NP_001368364.1
  • Confirmed by transcript evidence
NP_001368365.1
  • Confirmed by transcript evidence
NP_001368366.1
  • Confirmed by transcript evidence
NP_001368367.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7134346..7144720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001380310.2NP_001368366.1  E3 ubiquitin-protein ligase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CL75
    Conserved Domains (4) summary
    cd00078
    Location:21842611
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:345372
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:14151472
    MIB_HERC2; Mib_herc2
    cl23730
    Location:12061328
    F5_F8_type_C; F5/8 type C domain
  2. NM_001380311.1NP_001368364.1  E3 ubiquitin-protein ligase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLC0
    Conserved Domains (6) summary
    PTZ00322
    Location:383497
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd00078
    Location:22172644
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:345372
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:14481505
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:345436
    Ank_2; Ankyrin repeats (3 copies)
    cl23730
    Location:12391361
    F5_F8_type_C; F5/8 type C domain
  3. NM_001380312.2NP_001368365.1  E3 ubiquitin-protein ligase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLA7
    Conserved Domains (6) summary
    PTZ00322
    Location:383497
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd00078
    Location:22212648
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:345372
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:14521509
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:345436
    Ank_2; Ankyrin repeats (3 copies)
    cl23730
    Location:12431365
    F5_F8_type_C; F5/8 type C domain
  4. NM_001380309.1NP_001368367.1  E3 ubiquitin-protein ligase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CIS8
    Conserved Domains (4) summary
    cd00078
    Location:21802607
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:345372
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:14111468
    MIB_HERC2; Mib_herc2
    cl23730
    Location:12021324
    F5_F8_type_C; F5/8 type C domain
  5. NM_001380308.2NP_001368363.1  E3 ubiquitin-protein ligase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CIS4
    Conserved Domains (4) summary
    cd00078
    Location:21782605
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:345372
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:14091466
    MIB_HERC2; Mib_herc2
    cl23730
    Location:12001322
    F5_F8_type_C; F5/8 type C domain
  6. NM_001306760.2NP_001293689.1  E3 ubiquitin-protein ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293689.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CL74
    Conserved Domains (4) summary
    cd00078
    Location:21822609
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:345372
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:14131470
    MIB_HERC2; Mib_herc2
    cl23730
    Location:12041326
    F5_F8_type_C; F5/8 type C domain
  7. NM_001306762.2NP_001293691.1  E3 ubiquitin-protein ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293691.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CJX7
    Conserved Domains (6) summary
    PTZ00322
    Location:383497
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd00078
    Location:22152642
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:345372
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:14461503
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:345436
    Ank_2; Ankyrin repeats (3 copies)
    cl23730
    Location:12371359
    F5_F8_type_C; F5/8 type C domain
  8. NM_001306759.2NP_001293688.1  E3 ubiquitin-protein ligase hecd-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293688.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    V6CLA2
    Conserved Domains (6) summary
    PTZ00322
    Location:383497
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd00078
    Location:22192646
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:345372
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:14501507
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:345436
    Ank_2; Ankyrin repeats (3 copies)
    cl23730
    Location:12411363
    F5_F8_type_C; F5/8 type C domain
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