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Tiam1 TIAM Rac1 associated GEF 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304109, updated on 9-Dec-2024

Summary

Official Symbol
Tiam1provided by RGD
Official Full Name
TIAM Rac1 associated GEF 1provided by RGD
Primary source
RGD:1307455
See related
EnsemblRapid:ENSRNOG00000021569 AllianceGenome:RGD:1307455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables microtubule binding activity and receptor tyrosine kinase binding activity. Involved in several processes, including activation of GTPase activity; positive regulation of neurogenesis; and regulation of MAPK cascade. Located in several cellular components, including axon; dendritic spine; and ruffle membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with language delay and seizures. Orthologous to human TIAM1 (TIAM Rac1 associated GEF 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 116.8), Thymus (RPKM 34.2) and 8 other tissues See more
Orthologs
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Genomic context

See Tiam1 in Genome Data Viewer
Location:
11q11
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (42517527..42866280, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (29031347..29380153, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (29931083..30061173, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352304 Neighboring gene keratin associated protein 11-1 Neighboring gene mortality factor 4 like 1, pseudogene 8 Neighboring gene uncharacterized LOC134481052 Neighboring gene uncharacterized LOC134481051 Neighboring gene uncharacterized LOC102552925 Neighboring gene uncharacterized LOC134480968 Neighboring gene superoxide dismutase 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ephrin receptor binding  
enables guanyl-nucleotide exchange factor activity  
enables guanyl-nucleotide exchange factor activity  
enables kinase binding  
enables microtubule binding PubMed 
enables microtubule binding  
enables phospholipid binding  
enables protein binding PubMed 
enables receptor tyrosine kinase binding PubMed 
enables receptor tyrosine kinase binding  
Items 1 - 25 of 34
Process Evidence Code Pubs
involved_in Rac protein signal transduction  
involved_in activation of GTPase activity PubMed 
involved_in activation of GTPase activity  
involved_in brain-derived neurotrophic factor receptor signaling pathway  
involved_in cardiac muscle hypertrophy PubMed 
involved_in cell migration  
involved_in cell-matrix adhesion  
acts_upstream_of_or_within ephrin receptor signaling pathway  
involved_in neuron projection extension PubMed 
involved_in positive regulation of JUN kinase activity PubMed 
involved_in positive regulation of Schwann cell chemotaxis PubMed 
involved_in positive regulation of axonogenesis  
involved_in positive regulation of axonogenesis PubMed 
acts_upstream_of_or_within positive regulation of axonogenesis  
involved_in positive regulation of cell migration PubMed 
involved_in positive regulation of cell migration  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of dendritic spine morphogenesis PubMed 
involved_in positive regulation of neuron projection development PubMed 
involved_in positive regulation of neuron projection development  
involved_in protein localization to membrane PubMed 
involved_in protein-containing complex assembly  
involved_in regulation of ERK1 and ERK2 cascade PubMed 
involved_in regulation of dopaminergic neuron differentiation  
involved_in regulation of epithelial to mesenchymal transition  
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus PubMed 
involved_in regulation of modification of postsynaptic actin cytoskeleton PubMed 
involved_in regulation of modification of postsynaptic actin cytoskeleton PubMed 
involved_in regulation of non-canonical Wnt signaling pathway  
involved_in regulation of postsynapse organization PubMed 
involved_in regulation of postsynapse organization PubMed 
involved_in response to cocaine PubMed 
involved_in small GTPase-mediated signal transduction  
acts_upstream_of_or_within small GTPase-mediated signal transduction  
Items 1 - 25 of 34
Component Evidence Code Pubs
located_in axonal growth cone PubMed 
located_in cell-cell contact zone  
located_in cell-cell junction  
is_active_in cytosol  
located_in cytosol  
located_in dendritic spine PubMed 
is_active_in extrinsic component of postsynaptic density membrane PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
located_in kinocilium  
located_in main axon PubMed 
located_in microtubule PubMed 
located_in neuronal cell body PubMed 
located_in pericentriolar material  
is_active_in plasma membrane  
located_in plasma membrane  
located_in ruffle membrane PubMed 
located_in somatodendritic compartment PubMed 
is_active_in synapse  

General protein information

Preferred Names
rho guanine nucleotide exchange factor TIAM1
Names
T-cell lymphoma invasion and metastasis 1
T-lymphoma invasion and metastasis-inducing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100558.2NP_001094028.1  rho guanine nucleotide exchange factor TIAM1

    See identical proteins and their annotated locations for NP_001094028.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A8I6AC12, A6JLB5, D3ZWV8
    Related
    ENSRNOP00000089482.1, ENSRNOT00000109567.3
    Conserved Domains (6) summary
    smart00325
    Location:10431232
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:845924
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:431557
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12341405
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:571668
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    cl28922
    Location:765831
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    42517527..42866280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088432.2XP_038944360.1  rho guanine nucleotide exchange factor TIAM1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AC12, A6JLB5, D3ZWV8
    Conserved Domains (6) summary
    smart00325
    Location:10431232
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:845924
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:431557
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12341405
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:571668
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    cl28922
    Location:765831
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  2. XM_063270597.1XP_063126667.1  rho guanine nucleotide exchange factor TIAM1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AC12, A6JLB5, D3ZWV8
  3. XM_039088430.2XP_038944358.1  rho guanine nucleotide exchange factor TIAM1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AC12, A6JLB5, D3ZWV8
    Conserved Domains (6) summary
    smart00325
    Location:10431232
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:845924
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:431557
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12341405
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:571668
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    cl28922
    Location:765831
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  4. XM_039088434.2XP_038944362.1  rho guanine nucleotide exchange factor TIAM1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AC12, A6JLB5, D3ZWV8
    Conserved Domains (6) summary
    smart00325
    Location:10431232
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:845924
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:431557
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12341405
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:571668
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    cl28922
    Location:765831
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  5. XM_039088433.2XP_038944361.1  rho guanine nucleotide exchange factor TIAM1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AC12, A6JLB5, D3ZWV8
    Conserved Domains (6) summary
    smart00325
    Location:10431232
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:845924
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:431557
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12341405
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:571668
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    cl28922
    Location:765831
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  6. XM_063270598.1XP_063126668.1  rho guanine nucleotide exchange factor TIAM1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AC12, A6JLB5, D3ZWV8
  7. XM_039088429.2XP_038944357.1  rho guanine nucleotide exchange factor TIAM1 isoform X1

    UniProtKB/TrEMBL
    D3ZWV8
    Related
    ENSRNOP00000103376.1, ENSRNOT00000169253.1
    Conserved Domains (6) summary
    smart00325
    Location:10621251
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:864943
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:450576
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12531424
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:590687
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    cl28922
    Location:784850
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  8. XM_039088435.2XP_038944363.1  rho guanine nucleotide exchange factor TIAM1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6G1W3
    Related
    ENSRNOP00000104585.1, ENSRNOT00000152103.1
    Conserved Domains (2) summary
    smart00325
    Location:75264
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01255
    Location:266437
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
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