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    RBFOX1 RNA binding fox-1 homolog 1 [ Homo sapiens (human) ]

    Gene ID: 54715, updated on 10-Dec-2024

    Summary

    Official Symbol
    RBFOX1provided by HGNC
    Official Full Name
    RNA binding fox-1 homolog 1provided by HGNC
    Primary source
    HGNC:HGNC:18222
    See related
    Ensembl:ENSG00000078328 MIM:605104; AllianceGenome:HGNC:18222
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    2BP1; FOX1; A2BP1; FOX-1; HRNBP1
    Summary
    The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
    Expression
    Biased expression in brain (RPKM 11.3) and heart (RPKM 2.5) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RBFOX1 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (5239721..7713340)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (5269380..7744948)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (5289722..7763342)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371067 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:5262989-5263709 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:5286836-5288035 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5298918-5299751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:5300840-5301508 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5302176-5302843 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5302844-5303510 Neighboring gene 40S ribosomal protein S24-like Neighboring gene long intergenic non-protein coding RNA 2164 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:5371684-5372883 Neighboring gene VPS51 pseudogene 1 Neighboring gene RPS3A pseudogene 48 Neighboring gene small nuclear ribonucleoprotein polypeptide C pseudogene 20 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:5496759-5497327 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5500131-5500853 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5500854-5501575 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:5609581-5610780 Neighboring gene nucleophosmin 1 pseudogene 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:5692155-5693354 Neighboring gene MPRA-validated peak2482 silencer Neighboring gene MPRA-validated peak2483 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:5755936-5757135 Neighboring gene long intergenic non-protein coding RNA 1570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:5800209-5800710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:5800711-5801210 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:5804472-5805458 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:5845663-5846190 Neighboring gene microRNA 8065 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:5920971-5921940 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5975719-5976364 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:6052649-6053848 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:6072816-6074015 Neighboring gene meiotic recombination hotspot CG Neighboring gene NANOG hESC enhancer GRCh37_chr16:6174118-6174635 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6226269-6227053 Neighboring gene NANOG hESC enhancer GRCh37_chr16:6348193-6348738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6372883-6373383 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6372382-6372882 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6391810-6392696 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6392697-6393582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6532635-6533560 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancers GRCh37_chr16:6607366-6608270 and GRCh37_chr16:6608271-6609174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6623253-6623754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6623755-6624254 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6910998-6911814 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6913069-6913652 Neighboring gene RNA, U7 small nuclear 99 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6963086-6963586 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:6975920-6976594 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:6976595-6977269 Neighboring gene RNA, U6 small nuclear 457, pseudogene Neighboring gene MPRA-validated peak2485 silencer Neighboring gene uncharacterized LOC105371068 Neighboring gene RNA, U6 small nuclear 328, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:7231546-7232745 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:7234679-7235878 Neighboring gene Sharpr-MPRA regulatory region 8564 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_44361 Neighboring gene MPRA-validated peak2487 silencer Neighboring gene ribosomal protein S26 pseudogene 51 Neighboring gene uncharacterized LOC124903640 Neighboring gene NANOG hESC enhancer GRCh37_chr16:7481632-7482288 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:7629446-7630645 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:7701751-7702302 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:7703336-7703942 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:7758954-7760153 Neighboring gene uncharacterized LOC124900381 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:7814521-7815243 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:7815244-7815965 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:7819497-7820696 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:7917473-7918672 Neighboring gene uncharacterized LOC105371069

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Items 1 - 10 of 20
    Description
    A genome-wide association study of sleep habits and insomnia.
    EBI GWAS Catalog
    A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
    EBI GWAS Catalog
    Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
    EBI GWAS Catalog
    Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.
    EBI GWAS Catalog
    Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.
    EBI GWAS Catalog
    Genome-wide association and admixture analysis of glaucoma in the Women's Health Initiative.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association study and meta-analysis of intraocular pressure.
    EBI GWAS Catalog
    Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
    EBI GWAS Catalog
    Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.
    EBI GWAS Catalog
    Genome-wide association study of chronic periodontitis in a general German population.
    EBI GWAS Catalog
    Genome-Wide Association Study of Primary Dentition Pit-and-Fissure and Smooth Surface Caries.
    EBI GWAS Catalog
    Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
    EBI GWAS Catalog
    Genome-wide meta-analysis for severe diabetic retinopathy.
    EBI GWAS Catalog
    Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 Loci.
    EBI GWAS Catalog
    Genomewide association study of movement-related adverse antipsychotic effects.
    EBI GWAS Catalog
    Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
    EBI GWAS Catalog
    Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog
    Items 1 - 10 of 20

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding PubMed 
    enables mRNA binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing  
    involved_in RNA transport PubMed 
    involved_in mRNA processing  
    involved_in nervous system development  
    involved_in regulation of alternative mRNA splicing, via spliceosome  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasmic stress granule PubMed 
    located_in nuclear stress granule PubMed 
    is_active_in nucleus  
    located_in trans-Golgi network PubMed 

    General protein information

    Preferred Names
    RNA binding protein fox-1 homolog 1
    Names
    RNA binding protein, fox-1 homolog 1
    ataxin 2-binding protein 1
    fox-1 homolog A
    fox-1-like RNA-binding protein 1
    hexaribonucleotide-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011881.2 RefSeqGene

      Range
      784273..2478589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001142333.2NP_001135805.1  RNA binding protein fox-1 homolog 1 isoform 5

      See identical proteins and their annotated locations for NP_001135805.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus and other internal differences compared to isoform 1.
      Source sequence(s)
      AB208826, AC005774, AC009135, AF448859
      Consensus CDS
      CCDS55984.1
      UniProtKB/TrEMBL
      A0A087X2B1
      Related
      ENSP00000447753.1, ENST00000553186.5
      Conserved Domains (3) summary
      PRK03427
      Location:4122
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:226315
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:117192
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins
    2. NM_001142334.2NP_001135806.1  RNA binding protein fox-1 homolog 1 isoform 4

      See identical proteins and their annotated locations for NP_001135806.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and lacks an in-frame section of the 3' coding region, compared to variant 1. This results in a shorter isoform (4) with an alternate N-terminus compared to isoform 1. Variants 4 and 6 both encode isoform 4.
      Source sequence(s)
      AC005774, AF107203, AK001027
      Consensus CDS
      CCDS55983.1
      UniProtKB/Swiss-Prot
      Q7Z7I7, Q8TAE3, Q8TAF2, Q8WYB2, Q9NS20, Q9NWB1
      UniProtKB/TrEMBL
      I3L1D4
      Related
      ENSP00000447717.1, ENST00000547338.5
      Conserved Domains (3) summary
      PRK03427
      Location:4122
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:253342
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:117192
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins
    3. NM_001308117.1NP_001295046.1  RNA binding protein fox-1 homolog 1 isoform 6

      See identical proteins and their annotated locations for NP_001295046.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the UTRs and has multiple differences in the coding region which results in the use of an alternate start codon and a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (6) has a longer N-terminus and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC005774, AC027683, AK293951
      Consensus CDS
      CCDS76818.1
      UniProtKB/TrEMBL
      B7Z1U7, I3L1D4
      Related
      ENSP00000391269.4, ENST00000422070.8
      Conserved Domains (3) summary
      PRK03427
      Location:33165
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:296385
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:160235
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins
    4. NM_001364800.2NP_001351729.1  RNA binding protein fox-1 homolog 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152
      Consensus CDS
      CCDS92101.1
      UniProtKB/TrEMBL
      A0A6Q8PH77, F8VRS4
      Related
      ENSP00000502616.1, ENST00000675459.1
      Conserved Domains (3) summary
      PRK03427
      Location:4122
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:253339
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:117192
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins
    5. NM_001411047.1NP_001397976.1  RNA binding protein fox-1 homolog 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152
      Consensus CDS
      CCDS92100.1
      UniProtKB/TrEMBL
      F8VRS4, F8VZG9
      Related
      ENSP00000446842.1, ENST00000547372.5
    6. NM_001415887.1NP_001402816.1  RNA binding protein fox-1 homolog 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC005563, AC005774, AC007012, AC007217, AC012175, AC022206, AC023822, AC027683, AC074051, KF456152
      UniProtKB/TrEMBL
      A0A286YEU2
    7. NM_001415888.1NP_001402817.1  RNA binding protein fox-1 homolog 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC005563, AC005774, AC007012, AC007217, AC012175, AC022206, AC023822, AC027683, AC074051, KF456152
    8. NM_001415889.1NP_001402818.1  RNA binding protein fox-1 homolog 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007223, AC022206, AC027683, KF456152
      UniProtKB/TrEMBL
      F8VRS4
      Related
      ENSP00000438768.2, ENST00000535565.6
    9. NM_001415890.1NP_001402819.1  RNA binding protein fox-1 homolog 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152
      UniProtKB/TrEMBL
      A0A6Q8PFM4
    10. NM_001415891.1NP_001402820.1  RNA binding protein fox-1 homolog 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152
      UniProtKB/TrEMBL
      I3L1D4
    11. NM_001415892.1NP_001402821.1  RNA binding protein fox-1 homolog 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007223, AC022206, AC027683, KF456152
      UniProtKB/TrEMBL
      I3L1D4
    12. NM_001415893.1NP_001402822.1  RNA binding protein fox-1 homolog 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152
      UniProtKB/TrEMBL
      I3L1D4
      Related
      ENST00000676253.1
    13. NM_001415894.1NP_001402823.1  RNA binding protein fox-1 homolog 1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007223, AC022206, AC027683, KF456152
      UniProtKB/TrEMBL
      I3L1D4
    14. NM_001415895.1NP_001402824.1  RNA binding protein fox-1 homolog 1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152
      UniProtKB/TrEMBL
      F8VRS4
    15. NM_001415896.1NP_001402825.1  RNA binding protein fox-1 homolog 1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152
      UniProtKB/TrEMBL
      A0A087X2B1, X5DNY3
      Related
      ENSP00000484837.1, ENST00000620507.4
    16. NM_001415897.1NP_001402826.1  RNA binding protein fox-1 homolog 1 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152
      UniProtKB/TrEMBL
      A0A087X2B1
    17. NM_001415898.1NP_001402827.1  RNA binding protein fox-1 homolog 1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007223, AC022206, AC027683, KF456152
      UniProtKB/TrEMBL
      F8VRS4
      Related
      ENSP00000448496.1, ENST00000552089.5
    18. NM_001415899.1NP_001402828.1  RNA binding protein fox-1 homolog 1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152
      UniProtKB/TrEMBL
      I3L1D4
    19. NM_001415900.1NP_001402829.1  RNA binding protein fox-1 homolog 1 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007223, AC022206, AC027683, KF456152
      UniProtKB/TrEMBL
      A0A087X2B1
    20. NM_001415901.1NP_001402830.1  RNA binding protein fox-1 homolog 1 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152
      UniProtKB/TrEMBL
      A0A6Q8PFM4
      Related
      ENSP00000501878.1, ENST00000675562.1
    21. NM_001415902.1NP_001402831.1  RNA binding protein fox-1 homolog 1 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC027683, KF456152
      UniProtKB/TrEMBL
      I3L1D4
      Related
      ENSP00000458748.2, ENST00000570626.2
    22. NM_001415903.1NP_001402832.1  RNA binding protein fox-1 homolog 1 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152
      UniProtKB/TrEMBL
      A0A087X2B1
    23. NM_001415904.1NP_001402833.1  RNA binding protein fox-1 homolog 1 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152
      UniProtKB/TrEMBL
      A0A6Q8PFM4, X5D7T5
    24. NM_001415905.1NP_001402834.1  RNA binding protein fox-1 homolog 1 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152
      UniProtKB/TrEMBL
      I3L1D4
    25. NM_001415906.1NP_001402835.1  RNA binding protein fox-1 homolog 1 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152
      UniProtKB/TrEMBL
      B7ZLH9
    26. NM_001415907.1NP_001402836.1  RNA binding protein fox-1 homolog 1 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152
      UniProtKB/TrEMBL
      F8VRS4
    27. NM_001415908.1NP_001402837.1  RNA binding protein fox-1 homolog 1 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152
      UniProtKB/TrEMBL
      F8VRS4
    28. NM_001415909.1NP_001402838.1  RNA binding protein fox-1 homolog 1 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007223, AC022206, AC027683, KF456152
      UniProtKB/TrEMBL
      F8VRS4
    29. NM_001415910.1NP_001402839.1  RNA binding protein fox-1 homolog 1 isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007223, AC022206, AC027683, KF456152
      UniProtKB/TrEMBL
      F8VRS4
    30. NM_001415911.1NP_001402840.1  RNA binding protein fox-1 homolog 1 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC027683, KF456152
      UniProtKB/TrEMBL
      A0A6Q8PFM4, A0A804HJM2
      Related
      ENSP00000507562.1, ENST00000683326.1
    31. NM_001415912.1NP_001402841.1  RNA binding protein fox-1 homolog 1 isoform 34

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007223, AC022206, AC027683, KF456152
      UniProtKB/TrEMBL
      A0A087X2B1
    32. NM_001415913.1NP_001402842.1  RNA binding protein fox-1 homolog 1 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152
      UniProtKB/TrEMBL
      A0A6Q8PFM4
    33. NM_001415914.1NP_001402843.1  RNA binding protein fox-1 homolog 1 isoform 36

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152
      UniProtKB/TrEMBL
      A0A087X2B1
    34. NM_001415915.1NP_001402844.1  RNA binding protein fox-1 homolog 1 isoform 37

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007222, AC027683, KF456152
      UniProtKB/TrEMBL
      B7ZLH9, X5DP44
    35. NM_001415916.1NP_001402845.1  RNA binding protein fox-1 homolog 1 isoform 38

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC007012, AC007223, AC022206, AC027683, KF456152
      UniProtKB/TrEMBL
      I3L1D4
    36. NM_001415917.1NP_001402846.1  RNA binding protein fox-1 homolog 1 isoform 39

      Status: REVIEWED

      Source sequence(s)
      AC005774, AC027683, KF456152
      UniProtKB/TrEMBL
      A0A6Q8PFM4, A0A804HKG7
      Related
      ENSP00000507921.1, ENST00000682918.1
    37. NM_018723.4NP_061193.2  RNA binding protein fox-1 homolog 1 isoform 4

      See identical proteins and their annotated locations for NP_061193.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame section of the 3' coding region, compared to variant 1. This results in a shorter isoform (4) with an alternate N-terminus compared to isoform 1. Variants 4 and 6 both encode isoform 4.
      Source sequence(s)
      AB208826, AC005774, AC009135, AF107203
      Consensus CDS
      CCDS55983.1
      UniProtKB/Swiss-Prot
      Q7Z7I7, Q8TAE3, Q8TAF2, Q8WYB2, Q9NS20, Q9NWB1
      UniProtKB/TrEMBL
      I3L1D4
      Related
      ENSP00000450031.1, ENST00000550418.6
      Conserved Domains (3) summary
      PRK03427
      Location:4122
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:253342
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:117192
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins
    38. NM_145891.3NP_665898.1  RNA binding protein fox-1 homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_665898.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as gamma, encodes isoform (1).
      Source sequence(s)
      AC005774, AF229057
      Consensus CDS
      CCDS10531.1
      UniProtKB/TrEMBL
      B7ZLH9
      Related
      ENSP00000309117.5, ENST00000311745.9
      Conserved Domains (3) summary
      TIGR01661
      Location:25208
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      pfam12414
      Location:273363
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:137212
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins
    39. NM_145892.3NP_665899.1  RNA binding protein fox-1 homolog 1 isoform 2

      See identical proteins and their annotated locations for NP_665899.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as alpha, lacks an in-frame segment of the 3' coding region, compared to variant 1. This results in a shorter isoform (2) that lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC005774, AF094849
      Consensus CDS
      CCDS45405.1
      UniProtKB/TrEMBL
      I3L1D4
      Related
      ENSP00000402745.2, ENST00000436368.6
      Conserved Domains (3) summary
      TIGR01661
      Location:25208
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      pfam12414
      Location:273363
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:137212
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins
    40. NM_145893.3NP_665900.1  RNA binding protein fox-1 homolog 1 isoform 3

      See identical proteins and their annotated locations for NP_665900.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as beta, has an alternate exon in the 3' coding region, compared to variant 1. This results in a shorter isoform (3) with an alternate C-terminus, compared to isoform 1.
      Source sequence(s)
      AC005774, AF109106
      Consensus CDS
      CCDS10532.1
      UniProtKB/TrEMBL
      A0A6Q8PFM4
      Related
      ENSP00000347855.4, ENST00000355637.9
      Conserved Domains (3) summary
      TIGR01661
      Location:25208
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      pfam12414
      Location:273360
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:137212
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      5239721..7713340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023318.3XP_016878807.1  RNA binding protein fox-1 homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A286YEU2
      Related
      ENSP00000493041.1, ENST00000641259.1
    2. XM_024450303.2XP_024306071.1  RNA binding protein fox-1 homolog 1 isoform X2

      UniProtKB/TrEMBL
      A0A286YEU2
      Conserved Domains (4) summary
      PHA03169
      Location:18156
      PHA03169; hypothetical protein; Provisional
      cd12407
      Location:303378
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:439528
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl27169
      Location:176308
      ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...
    3. XM_017023320.3XP_016878809.1  RNA binding protein fox-1 homolog 1 isoform X3

      UniProtKB/TrEMBL
      F8VRS4
      Conserved Domains (4) summary
      PHA03193
      Location:88155
      PHA03193; tegument protein VP11/12; Provisional
      COG0724
      Location:143243
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:160235
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:296383
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    4. XM_017023321.3XP_016878810.1  RNA binding protein fox-1 homolog 1 isoform X4

      UniProtKB/TrEMBL
      F8VRS4
      Conserved Domains (3) summary
      PRK03427
      Location:26158
      PRK03427; cell division protein ZipA; Provisional
      cd12407
      Location:153228
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:289378
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    5. XM_024450305.2XP_024306073.1  RNA binding protein fox-1 homolog 1 isoform X7

      UniProtKB/TrEMBL
      F8VRS4
      Conserved Domains (3) summary
      cd12407
      Location:153228
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:262350
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl27169
      Location:26158
      ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...
    6. XM_005255391.5XP_005255448.1  RNA binding protein fox-1 homolog 1 isoform X9

      See identical proteins and their annotated locations for XP_005255448.1

      UniProtKB/TrEMBL
      A0A6Q8PFM4
      Conserved Domains (3) summary
      PRK03427
      Location:4122
      PRK03427; cell division protein ZipA; Provisional
      cd12407
      Location:117192
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:253342
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    7. XM_047434244.1XP_047290200.1  RNA binding protein fox-1 homolog 1 isoform X9

      UniProtKB/TrEMBL
      A0A6Q8PFM4
    8. XM_005255386.5XP_005255443.1  RNA binding protein fox-1 homolog 1 isoform X5

      UniProtKB/TrEMBL
      A0A6Q8PFM4
      Conserved Domains (4) summary
      PHA03193
      Location:70137
      PHA03193; tegument protein VP11/12; Provisional
      COG0724
      Location:125225
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:142217
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:278365
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    9. XM_005255387.5XP_005255444.1  RNA binding protein fox-1 homolog 1 isoform X6

      See identical proteins and their annotated locations for XP_005255444.1

      UniProtKB/TrEMBL
      A0A6Q8PFM4
      Conserved Domains (3) summary
      TIGR01661
      Location:25208
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      pfam12414
      Location:273360
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:137212
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins
    10. XM_024450306.2XP_024306074.1  RNA binding protein fox-1 homolog 1 isoform X10

      UniProtKB/TrEMBL
      B7Z608
      Conserved Domains (3) summary
      PRK14971
      Location:19187
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam12414
      Location:242331
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl17169
      Location:137176
      RRM_SF; RNA recognition motif (RRM) superfamily
    11. XM_047434249.1XP_047290205.1  RNA binding protein fox-1 homolog 1 isoform X11

      UniProtKB/TrEMBL
      A0A087X2B1
    12. XM_047434243.1XP_047290199.1  RNA binding protein fox-1 homolog 1 isoform X8

      UniProtKB/TrEMBL
      A0A6Q8PFM4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      5269380..7744948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380514.1XP_054236489.1  RNA binding protein fox-1 homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A286YEU2
    2. XM_054380515.1XP_054236490.1  RNA binding protein fox-1 homolog 1 isoform X2

      UniProtKB/TrEMBL
      A0A286YEU2
    3. XM_054380516.1XP_054236491.1  RNA binding protein fox-1 homolog 1 isoform X3

      UniProtKB/TrEMBL
      F8VRS4
    4. XM_054380520.1XP_054236495.1  RNA binding protein fox-1 homolog 1 isoform X7

      UniProtKB/TrEMBL
      F8VRS4
    5. XM_054380517.1XP_054236492.1  RNA binding protein fox-1 homolog 1 isoform X4

      UniProtKB/TrEMBL
      F8VRS4
    6. XM_054380523.1XP_054236498.1  RNA binding protein fox-1 homolog 1 isoform X9

      UniProtKB/TrEMBL
      A0A6Q8PFM4
    7. XM_054380521.1XP_054236496.1  RNA binding protein fox-1 homolog 1 isoform X12

      UniProtKB/TrEMBL
      F8VRS4
    8. XM_054380518.1XP_054236493.1  RNA binding protein fox-1 homolog 1 isoform X5

      UniProtKB/TrEMBL
      A0A6Q8PFM4
    9. XM_054380519.1XP_054236494.1  RNA binding protein fox-1 homolog 1 isoform X6

      UniProtKB/TrEMBL
      A0A6Q8PFM4
    10. XM_054380524.1XP_054236499.1  RNA binding protein fox-1 homolog 1 isoform X10

      UniProtKB/TrEMBL
      B7Z608
    11. XM_054380526.1XP_054236501.1  RNA binding protein fox-1 homolog 1 isoform X13

      UniProtKB/TrEMBL
      A0A6Q8PFM4
    12. XM_054380522.1XP_054236497.1  RNA binding protein fox-1 homolog 1 isoform X8

      UniProtKB/TrEMBL
      A0A6Q8PFM4
    13. XM_054380525.1XP_054236500.1  RNA binding protein fox-1 homolog 1 isoform X11

      UniProtKB/TrEMBL
      A0A087X2B1
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