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Ddr1 discoidin domain receptor family, member 1 [ Mus musculus (house mouse) ]

Gene ID: 12305, updated on 9-Dec-2024

Summary

Official Symbol
Ddr1provided by MGI
Official Full Name
discoidin domain receptor family, member 1provided by MGI
Primary source
MGI:MGI:99216
See related
Ensembl:ENSMUSG00000003534 AllianceGenome:MGI:99216
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cak; Nep; PTK3A; CD167a; 6030432F18
Summary
Enables collagen binding activity. Involved in several processes, including regulation of extracellular matrix disassembly; smooth muscle cell-matrix adhesion; and wound healing, spreading of cells. Acts upstream of or within several processes, including collagen-activated tyrosine kinase receptor signaling pathway; mammary gland development; and neuron projection development. Located in plasma membrane. Is expressed in several structures, including central nervous system; future hindbrain; genitourinary system; mammary gland; and retina. Human ortholog(s) of this gene implicated in breast carcinoma; idiopathic pulmonary fibrosis; lung non-small cell carcinoma; osteosarcoma; and skin melanoma. Orthologous to human DDR1 (discoidin domain receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 32.9), colon adult (RPKM 31.1) and 24 other tissues See more
Orthologs
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Genomic context

See Ddr1 in Genome Data Viewer
Location:
17 B1; 17 18.7 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35992459..36015633, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35681567..35704741, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7529 Neighboring gene valyl-tRNA synthetase 2, mitochondrial Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:35808865-35809171 Neighboring gene STARR-positive B cell enhancer ABC_E7530 Neighboring gene general transcription factor II H, polypeptide 4 Neighboring gene STARR-seq mESC enhancer starr_42470 Neighboring gene STARR-seq mESC enhancer starr_42472 Neighboring gene predicted gene, 23864 Neighboring gene predicted gene 4577 Neighboring gene VISTA enhancer mm90 Neighboring gene STARR-positive B cell enhancer mm9_chr17:35874761-35875062 Neighboring gene predicted gene 20443 Neighboring gene RIKEN cDNA 4833427F10 gene Neighboring gene predicted gene, 32409

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 26
Function Evidence Code Pubs
enables ATP binding  
enables GPI-linked ephrin receptor activity  
enables boss receptor activity  
enables brain-derived neurotrophic factor receptor activity  
enables collagen binding  
enables collagen binding PubMed 
enables collagen binding PubMed 
enables collagen binding  
enables epidermal growth factor receptor activity  
enables fibroblast growth factor receptor activity  
enables hepatocyte growth factor receptor activity  
enables histone H2AXY142 kinase activity  
enables histone H3Y41 kinase activity  
enables insulin receptor activity  
enables insulin-like growth factor receptor activity  
enables macrophage colony-stimulating factor receptor activity  
enables metal ion binding  
enables placental growth factor receptor activity  
enables platelet-derived growth factor alpha-receptor activity  
enables platelet-derived growth factor beta-receptor activity  
enables protein tyrosine kinase collagen receptor activity  
enables protein tyrosine kinase collagen receptor activity  
enables protein tyrosine kinase collagen receptor activity  
enables stem cell factor receptor activity  
enables transmembrane-ephrin receptor activity  
enables vascular endothelial growth factor receptor activity  
Items 1 - 25 of 26
Items 1 - 25 of 46
Process Evidence Code Pubs
involved_in Kit signaling pathway  
acts_upstream_of_or_within axon development PubMed 
involved_in brain-derived neurotrophic factor receptor signaling pathway  
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis PubMed 
acts_upstream_of cell population proliferation PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway  
involved_in chromatin remodeling  
acts_upstream_of_or_within collagen-activated tyrosine kinase receptor signaling pathway PubMed 
involved_in collagen-activated tyrosine kinase receptor signaling pathway PubMed 
involved_in collagen-activated tyrosine kinase receptor signaling pathway  
acts_upstream_of_or_within ear development PubMed 
acts_upstream_of_or_within embryo implantation PubMed 
involved_in ephrin receptor signaling pathway  
involved_in epidermal growth factor receptor signaling pathway  
involved_in fibroblast growth factor receptor signaling pathway  
involved_in hepatocyte growth factor receptor signaling pathway  
involved_in insulin receptor signaling pathway  
involved_in insulin-like growth factor receptor signaling pathway  
involved_in lactation  
involved_in macrophage colony-stimulating factor signaling pathway  
acts_upstream_of_or_within mammary gland alveolus development PubMed 
involved_in multicellular organism development  
acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
acts_upstream_of_or_within neuron projection extension PubMed 
acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation PubMed 
involved_in peptidyl-tyrosine autophosphorylation  
involved_in peptidyl-tyrosine autophosphorylation  
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation PubMed 
involved_in platelet-derived growth factor receptor-alpha signaling pathway  
involved_in platelet-derived growth factor receptor-beta signaling pathway  
involved_in positive regulation of neuron projection development  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
acts_upstream_of_or_within protein autophosphorylation PubMed 
involved_in protein autophosphorylation  
acts_upstream_of_or_within regulation of cell growth PubMed 
acts_upstream_of_or_within regulation of cell-matrix adhesion PubMed 
involved_in regulation of extracellular matrix disassembly PubMed 
involved_in regulation of extracellular matrix disassembly  
involved_in smooth muscle cell migration PubMed 
involved_in smooth muscle cell migration  
involved_in smooth muscle cell-matrix adhesion PubMed 
involved_in smooth muscle cell-matrix adhesion  
involved_in vascular endothelial growth factor receptor-1 signaling pathway  
involved_in vascular endothelial growth factor signaling pathway  
involved_in wound healing, spreading of cells PubMed 
involved_in wound healing, spreading of cells  
Items 1 - 25 of 46
Component Evidence Code Pubs
located_in basolateral plasma membrane  
located_in brush border  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
part_of receptor complex  
part_of receptor complex PubMed 

General protein information

Preferred Names
epithelial discoidin domain-containing receptor 1
Names
CD167 antigen-like family member A
cell adhesion kinase
discoidin receptor tyrosine kinase
epithelial discoidin domain receptor 1
protein-tyrosine kinase MPK-6
tyrosine kinase DDR
tyrosine-protein kinase CAK
NP_001185760.1
NP_001185762.1
NP_001411562.1
NP_001411564.1
NP_001411566.1
NP_001411568.1
NP_001411569.1
NP_001411570.1
NP_031610.1
NP_766550.1
XP_006523598.1
XP_006523599.1
XP_006523600.1
XP_011244561.1
XP_030105324.1
XP_036016169.1
XP_036016171.1
XP_036016172.1
XP_036016173.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198831.1NP_001185760.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001185760.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 3, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AK143088, BC037108, CK790776, L57509
    Consensus CDS
    CCDS28703.1
    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    O35407
    Related
    ENSMUSP00000133047.3, ENSMUST00000166980.9
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001198833.1NP_001185762.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001185762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 3, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AK143088, BC037108, BY062785, L57509
    Consensus CDS
    CCDS28703.1
    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    O35407
    Related
    ENSMUSP00000113062.2, ENSMUST00000119825.8
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001424633.1NP_001411562.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    CR974483
    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    O35407
  4. NM_001424635.1NP_001411564.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    CR974483
    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    O35407
  5. NM_001424637.1NP_001411566.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CR974483
    UniProtKB/TrEMBL
    O35407, Q544T2
  6. NM_001424639.1NP_001411568.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CR974483
    UniProtKB/TrEMBL
    O35407, Q544T2
  7. NM_001424640.1NP_001411569.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CR974483
    UniProtKB/TrEMBL
    O35407, Q544T2
  8. NM_001424641.1NP_001411570.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CR974483
    UniProtKB/TrEMBL
    O35407, Q544T2
  9. NM_007584.3NP_031610.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_031610.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 3, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AK143088, BC037108, L57509
    Consensus CDS
    CCDS28703.1
    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    O35407
    Related
    ENSMUSP00000112570.2, ENSMUST00000117301.8
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  10. NM_172962.2NP_766550.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_766550.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1, and encodes a shorter isoform (2) than isoform 1.
    Source sequence(s)
    CR974483
    Consensus CDS
    CCDS37603.1
    UniProtKB/TrEMBL
    O35407, Q544T2
    Related
    ENSMUSP00000094945.4, ENSMUST00000097333.10
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:565868
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35992459..36015633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523536.4XP_006523599.1  epithelial discoidin domain-containing receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006523599.1

    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    O35407
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  2. XM_030249464.2XP_030105324.1  epithelial discoidin domain-containing receptor 1 isoform X2

    UniProtKB/TrEMBL
    O35407, Q544T2
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:565868
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006523537.3XP_006523600.1  epithelial discoidin domain-containing receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006523600.1

    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    O35407
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  4. XM_036160276.1XP_036016169.1  epithelial discoidin domain-containing receptor 1 isoform X2

    UniProtKB/TrEMBL
    O35407, Q544T2
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:565868
    PKc_like; Protein Kinases, catalytic domain
  5. XM_006523535.5XP_006523598.1  epithelial discoidin domain-containing receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006523598.1

    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    O35407
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  6. XM_036160280.1XP_036016173.1  epithelial discoidin domain-containing receptor 1 isoform X2

    UniProtKB/TrEMBL
    O35407, Q544T2
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:565868
    PKc_like; Protein Kinases, catalytic domain
  7. XM_036160279.1XP_036016172.1  epithelial discoidin domain-containing receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    O35407
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  8. XM_036160278.1XP_036016171.1  epithelial discoidin domain-containing receptor 1 isoform X2

    UniProtKB/TrEMBL
    O35407, Q544T2
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:565868
    PKc_like; Protein Kinases, catalytic domain
  9. XM_011246259.3XP_011244561.1  epithelial discoidin domain-containing receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011244561.1

    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    O35407
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001782030.3 RNA Sequence

  2. XR_004939465.1 RNA Sequence

  3. XR_004939464.1 RNA Sequence

    Related
    ENSMUST00000155957.8
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