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    DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 [ Homo sapiens (human) ]

    Gene ID: 3301, updated on 10-Dec-2024

    Summary

    Official Symbol
    DNAJA1provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member A1provided by HGNC
    Primary source
    HGNC:HGNC:5229
    See related
    Ensembl:ENSG00000086061 MIM:602837; AllianceGenome:HGNC:5229
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DJ-2; DjA1; HDJ2; HSDJ; HSJ2; HSJ-2; HSPF4; NEDD7; hDJ-2
    Summary
    This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in testis (RPKM 94.7), brain (RPKM 86.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See DNAJA1 in Genome Data Viewer
    Location:
    9p21.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (33025273..33039907)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (33041834..33056468)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (33025271..33039905)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene aprataxin Neighboring gene uncharacterized LOC124902139 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:33024111-33024706 Neighboring gene Sharpr-MPRA regulatory region 3987 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:33025301-33025895 Neighboring gene L antigen family member 3 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:33043981-33044482 Neighboring gene SMU1 DNA replication regulator and spliceosomal factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28272 Neighboring gene beta-1,4-galactosyltransferase 1 Neighboring gene microRNA 12117

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of DnaJ (Hsp40) homolog, subfamily A, member 1 (DNAJA1) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev The expression of HSP40A1 (DNAJA1) inhibits HIV-1 Rev expression at the posttranscriptional levels, leading to the reduction of HIV-1 RNA accumulation PubMed
    Vif vif HIV-1 Vif interacts with DNAJA1; interaction predicted to be relevant in protein folding and/or macromolecular structure assembly PubMed
    capsid gag HSP40A1 (DNAJA1) inhibits HIV-1 production as measured by the level of viral p24 capsid in the culture supernatant. The HSP40A1 (1-83) mutant lacking most of the C-terminal portion is more potent in inhibiting HIV-1 production than its wild-type PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATPase activator activity PubMed 
    enables C3HC4-type RING finger domain binding PubMed 
    enables G protein-coupled receptor binding PubMed 
    enables Hsp70 protein binding PubMed 
    enables Tat protein binding PubMed 
    enables low-density lipoprotein particle receptor binding PubMed 
    enables metal ion binding  
    enables protein binding PubMed 
    enables protein-folding chaperone binding  
    enables protein-folding chaperone binding PubMed 
    enables protein-folding chaperone binding PubMed 
    enables ubiquitin protein ligase binding PubMed 
    enables unfolded protein binding  
    Process Evidence Code Pubs
    involved_in androgen receptor signaling pathway  
    involved_in flagellated sperm motility  
    involved_in negative regulation of JUN kinase activity PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of establishment of protein localization to mitochondrion PubMed 
    involved_in negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway PubMed 
    involved_in negative regulation of protein ubiquitination PubMed 
    involved_in positive regulation of apoptotic process PubMed 
    involved_in protein folding PubMed 
    involved_in protein localization to mitochondrion PubMed 
    involved_in protein refolding  
    involved_in regulation of protein transport PubMed 
    involved_in response to heat  
    involved_in response to unfolded protein PubMed 
    involved_in spermatogenesis  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasmic side of endoplasmic reticulum membrane PubMed 
    is_active_in cytosol  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in extracellular exosome PubMed 
    located_in membrane PubMed 
    located_in membrane PubMed 
    located_in microtubule cytoskeleton  
    located_in mitochondrion  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    dnaJ homolog subfamily A member 1
    Names
    DnaJ (Hsp40) homolog, subfamily A, member 1
    dnaJ protein homolog 2
    heat shock 40 kDa protein 4
    heat shock protein J2
    heat shock protein, DNAJ-like 2
    human DnaJ protein 2
    neural precursor cell expressed, developmentally down-regulated 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001314039.2NP_001300968.1  dnaJ homolog subfamily A member 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK095541, AK298725, BM469197, BU508753, DA003255, DB575768
      UniProtKB/TrEMBL
      B7Z5C0, Q9NXZ8
      Conserved Domains (1) summary
      PTZ00037
      Location:2237
      PTZ00037; DnaJ_C chaperone protein; Provisional
    2. NM_001539.4NP_001530.1  dnaJ homolog subfamily A member 1 isoform 1

      See identical proteins and their annotated locations for NP_001530.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK095541, BC008182, BI462555, BU508753, DB575768
      Consensus CDS
      CCDS6533.1
      UniProtKB/Swiss-Prot
      P31689, Q5T7Q0, Q86TL9
      Related
      ENSP00000369127.3, ENST00000330899.5
      Conserved Domains (1) summary
      PTZ00037
      Location:2394
      PTZ00037; DnaJ_C chaperone protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      33025273..33039907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      33041834..33056468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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