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    GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 23062, updated on 10-Dec-2024

    Summary

    Official Symbol
    GGA2provided by HGNC
    Official Full Name
    golgi associated, gamma adaptin ear containing, ARF binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:16064
    See related
    Ensembl:ENSG00000103365 MIM:606005; AllianceGenome:HGNC:16064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VEAR
    Summary
    This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 28.0), thyroid (RPKM 15.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GGA2 in Genome Data Viewer
    Location:
    16p12.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (23463542..23524359, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (23739620..23800145, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (23474863..23521815, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene component of oligomeric golgi complex 7 Neighboring gene RN7SK pseudogene 23 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:23435589-23436134 Neighboring gene uncharacterized LOC124903667 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:23511811-23512473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23515779-23516280 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23516281-23516780 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7277 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7278 Neighboring gene cyclin Y like 7 (pseudogene) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10582 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:23549327-23549828 Neighboring gene glutamyl-tRNA synthetase 2, mitochondrial Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:23549829-23550328 Neighboring gene SUB1 pseudogene 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:23567356-23568000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10583 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:23568645-23569289 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:23569290-23569933 Neighboring gene ubiquitin family domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Genome-wide shRNA screening identifies GGA2, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed
    Pr55(Gag) gag siRNA-mediated depletion of GGA2 leads to a significant increase in particle release in an HIV-1 Gag late domain-dependent manner, while GGA2 overexpression severely reduces virus particle production by impairing Gag trafficking to the membrane PubMed
    Vpr vpr Expression of a patient-derived HIV-1 Vpr protein reveals a significant reduction in Vpr nuclear import. Vpr F72L mutation is responsible for this decreased Vpr nuclear import and the F72L mutant is co-localized with gamma-adaptin in the Golgi apparatus PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Clone Names

    • FLJ20966, KIAA1080

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidylinositol binding  
    enables protein binding PubMed 
    enables small GTPase binding  
    enables small GTPase binding PubMed 
    enables ubiquitin binding  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in clathrin-coated vesicle PubMed 
    located_in early endosome membrane  
    located_in endosome membrane  
    is_active_in trans-Golgi network  
    located_in trans-Golgi network PubMed 

    General protein information

    Preferred Names
    ADP-ribosylation factor-binding protein GGA2
    Names
    VHS domain and ear domain of gamma-adaptin
    VHS domain and ear domain-containing protein
    gamma-adaptin-related protein 2
    golgi-localized, gamma ear-containing, ARF-binding protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015044.4NP_055859.1  ADP-ribosylation factor-binding protein GGA2

      See identical proteins and their annotated locations for NP_055859.1

      Status: REVIEWED

      Source sequence(s)
      AC008915, AF165531, DA439738
      Consensus CDS
      CCDS10611.1
      UniProtKB/Swiss-Prot
      D3DWF0, O14564, Q9NYN2, Q9UJY4, Q9UPS2
      Related
      ENSP00000311962.4, ENST00000309859.8
      Conserved Domains (4) summary
      smart00809
      Location:491605
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd03567
      Location:25163
      VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
      cd14239
      Location:227315
      GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
      cl21478
      Location:168240
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      23463542..23524359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433801.1XP_047289757.1  ADP-ribosylation factor-binding protein GGA2 isoform X1

    2. XM_047433802.1XP_047289758.1  ADP-ribosylation factor-binding protein GGA2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      23739620..23800145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379851.1XP_054235826.1  ADP-ribosylation factor-binding protein GGA2 isoform X1

    2. XM_054379852.1XP_054235827.1  ADP-ribosylation factor-binding protein GGA2 isoform X2

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