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    eat-4 Major facilitator superfamily (MFS) profile domain-containing protein;putative vesicular glutamate transporter eat-4 [ Caenorhabditis elegans ]

    Gene ID: 176291, updated on 9-Dec-2024

    Summary

    Official Symbol
    eat-4
    Official Full Name
    Major facilitator superfamily (MFS) profile domain-containing protein;putative vesicular glutamate transporter eat-4
    Primary source
    WormBase:WBGene00001135
    Locus tag
    CELE_ZK512.6
    See related
    AllianceGenome:WB:WBGene00001135
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable L-glutamate transmembrane transporter activity; glutamate:sodium symporter activity; and neurotransmitter transmembrane transporter activity. Involved in several processes, including glutamatergic synaptic transmission; positive regulation of backward locomotion; and regulation of male mating behavior. Predicted to be located in plasma membrane and presynapse. Predicted to be active in excitatory synapse and synaptic vesicle membrane. Is expressed in intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Orthologous to several human genes including SLC17A7 (solute carrier family 17 member 7) and SLC17A8 (solute carrier family 17 member 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See eat-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    12
    Sequence:
    Chromosome: III; NC_003281.10 (9136887..9141827)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DUF4752 family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ATP-dependent RNA helicase;putative ATP-dependent RNA helicase DDX55 homolog Neighboring gene Uncharacterized protein Neighboring gene Signal recognition particle 9 kDa protein

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables L-glutamate transmembrane transporter activity  
    enables glutamate:sodium symporter activity PubMed 
    enables neurotransmitter transmembrane transporter activity  
    enables symporter activity  
    enables transmembrane transporter activity  
    Process Evidence Code Pubs
    involved_in L-glutamate transmembrane transport  
    involved_in L-glutamate transmembrane transport PubMed 
    involved_in adult locomotory behavior PubMed 
    involved_in hyperosmotic response PubMed 
    involved_in negative regulation of turning behavior involved in mating PubMed 
    involved_in neurotransmitter loading into synaptic vesicle  
    involved_in neurotransmitter transport  
    involved_in positive regulation of backward locomotion PubMed 
    involved_in positive regulation of backward locomotion PubMed 
    involved_in positive regulation of male mating behavior PubMed 
    involved_in regulation of nematode pharyngeal pumping PubMed 
    involved_in regulation of nematode pharyngeal pumping PubMed 
    involved_in regulation of synapse structure or activity  
    involved_in response to mechanical stimulus PubMed 
    involved_in response to mechanical stimulus PubMed 
    involved_in sodium ion transport  
    involved_in synaptic transmission, glutamatergic  
    involved_in synaptic transmission, glutamatergic PubMed 
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    is_active_in excitatory synapse  
    located_in membrane  
    located_in plasma membrane  
    located_in presynapse  
    located_in synapse  
    is_active_in synaptic vesicle membrane  
    located_in synaptic vesicle membrane PubMed 

    General protein information

    Preferred Names
    Major facilitator superfamily (MFS) profile domain-containing protein;putative vesicular glutamate transporter eat-4
    NP_001293625.1
    • Confirmed by transcript evidence
    NP_499023.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9136887..9141827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066622.6NP_499023.3  putative vesicular glutamate transporter eat-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499023.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34644, Q9TZN7
      Conserved Domains (2) summary
      cd06174
      Location:110492
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:66497
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
    2. NM_001306696.3NP_001293625.1  Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293625.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6DQ91
      Conserved Domains (1) summary
      cd17382
      Location:52471
      MFS_SLC17A6_7_8_VGluT; Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters
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