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    Rpain RPA interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 69723, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rpainprovided by MGI
    Official Full Name
    RPA interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1916973
    See related
    Ensembl:ENSMUSG00000018449 AllianceGenome:MGI:1916973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rip; 2400006N03Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within DNA metabolic process and response to UV. Predicted to be located in PML body; cytoplasm; and fibrillar center. Predicted to be active in nucleus. Is expressed in several structures, including cerebral cortex ventricular layer; egg cylinder; and oocyte. Orthologous to human RPAIN (RPA interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 17.5), testis adult (RPKM 16.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rpain in Genome Data Viewer
    Location:
    11 B4; 11 43.21 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70860403..70868759)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70970130..70977933)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene rabaptin, RAB GTPase binding effector protein 1 Neighboring gene ribosomal protein L23A, pseudogene 2 Neighboring gene predicted gene 12322 Neighboring gene nucleoporin 88 Neighboring gene STARR-seq mESC enhancer starr_29882 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70783671-70783780 Neighboring gene complement component 1, q subcomponent binding protein Neighboring gene DEAH-box helicase 33 Neighboring gene STARR-positive B cell enhancer ABC_E2359 Neighboring gene predicted gene, 22297 Neighboring gene STARR-positive B cell enhancer ABC_E256 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70833281-70833468 Neighboring gene Der1-like domain family, member 2 Neighboring gene MIS12 kinetochore complex component

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding  
    enables protein-containing complex binding  
    Component Evidence Code Pubs
    located_in PML body  
    located_in cytoplasm  
    located_in fibrillar center  
    located_in fibrillar center  
    located_in nucleoplasm  
    is_active_in nucleus  

    General protein information

    Preferred Names
    RPA-interacting protein
    Names
    RPA interacting protein delta 2
    RPA interacting protein epsilon

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252413.2NP_001239342.1  RPA-interacting protein isoform 3

      See identical proteins and their annotated locations for NP_001239342.1

      Status: VALIDATED

      Source sequence(s)
      AL596136, BC047996, BY576068, CB588111, DQ810269
      Consensus CDS
      CCDS56791.1
      UniProtKB/TrEMBL
      Q0PL81, Q0PL82
      Related
      ENSMUSP00000127315.2, ENSMUST00000167509.2
      Conserved Domains (3) summary
      pfam14766
      Location:846
      RPA_interact_N; Replication protein A interacting N-terminal
      pfam14767
      Location:59123
      RPA_interact_M; Replication protein A interacting middle
      pfam14768
      Location:137164
      RPA_interact_C; Replication protein A interacting C-terminal
    2. NM_001252414.2NP_001239343.1  RPA-interacting protein isoform 4

      See identical proteins and their annotated locations for NP_001239343.1

      Status: VALIDATED

      Source sequence(s)
      AL596136, BC047996, BY576068, CB588111, DQ810271
      Consensus CDS
      CCDS56792.1
      UniProtKB/TrEMBL
      Q0PL79, Q0PL80
      Related
      ENSMUSP00000128903.2, ENSMUST00000169965.8
      Conserved Domains (1) summary
      pfam14766
      Location:846
      RPA_interact_N; Replication protein A interacting N-terminal
    3. NM_001252415.2NP_001239344.1  RPA-interacting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596136, BC047996, BY576068, CB588111, DQ810268
      Consensus CDS
      CCDS56790.1
      UniProtKB/TrEMBL
      J3QN46, Q0PL82
      Related
      ENSMUSP00000136592.2, ENSMUST00000178822.8
      Conserved Domains (3) summary
      pfam14766
      Location:846
      RPA_interact_N; Replication protein A interacting N-terminal
      pfam14767
      Location:59123
      RPA_interact_M; Replication protein A interacting middle
      pfam14768
      Location:137165
      RPA_interact_C; Replication protein A interacting C-terminal
    4. NM_027186.3NP_081462.1  RPA-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_081462.1

      Status: VALIDATED

      Source sequence(s)
      AK010289, AL596136, BC047996, BY576068, CB588111
      Consensus CDS
      CCDS24969.1
      UniProtKB/Swiss-Prot
      Q9CWY9
      UniProtKB/TrEMBL
      Q0PL83
      Related
      ENSMUSP00000018593.4, ENSMUST00000018593.10
      Conserved Domains (3) summary
      pfam14766
      Location:846
      RPA_interact_N; Replication protein A interacting N-terminal
      pfam14767
      Location:59123
      RPA_interact_M; Replication protein A interacting middle
      pfam14768
      Location:137217
      RPA_interact_C; Replication protein A interacting C-terminal

    RNA

    1. NR_156443.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL596136

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70860403..70868759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003949500.2 RNA Sequence

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