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BMP7 bone morphogenetic protein 7 [ Homo sapiens (human) ]

Gene ID: 655, updated on 10-Dec-2024

Summary

Official Symbol
BMP7provided by HGNC
Official Full Name
bone morphogenetic protein 7provided by HGNC
Primary source
HGNC:HGNC:1074
See related
Ensembl:ENSG00000101144 MIM:112267; AllianceGenome:HGNC:1074
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OP-1
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]
Expression
Biased expression in thyroid (RPKM 30.0), placenta (RPKM 15.8) and 9 other tissues See more
Orthologs
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Genomic context

See BMP7 in Genome Data Viewer
Location:
20q13.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (57168753..57266641, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (58946552..59044382, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (55743809..55841697, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55707263-55707764 Neighboring gene VISTA enhancer hs2565 Neighboring gene uncharacterized LOC105372686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55736368-55736868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55747859-55748360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55758285-55758807 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55758808-55759329 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:55773380-55774038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:55774039-55774698 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:55780300-55781499 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55798567-55799068 Neighboring gene BMP7 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55801141-55801641 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:55806824-55807357 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:55807358-55807890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55819232-55820156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55834429-55834991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55837926-55838642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55839361-55840076 Neighboring gene BMP7 promoter region Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC105372687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55861989-55862490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55862491-55862990 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55865617-55866584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55867403-55867902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55876343-55876878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55892097-55892598 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:55901391-55901894 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:55901895-55902397 Neighboring gene microRNA 4325 Neighboring gene ribosomal protein L39 pseudogene 39

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genomewide association study of citalopram response in major depressive disorder.
EBI GWAS Catalog
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 reduces osteoblast function and significantly decreases the levels of BMP-7 and RANK-L PubMed
Pr55(Gag) gag HIV-1 Gag reduces osteoblast function and significantly reduces the levels of BMP-2, BMP-7, osteocalcin, and RANK-L PubMed
Tat tat Treatment of pulmonary arterial smooth muscle cells with HIV-1 Tat induces significantly higher secretion of BMP-2 and BMP-7 ligands when compared with that of untreated cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables BMP receptor binding PubMed 
enables cytokine activity  
enables growth factor activity PubMed 
enables heparin binding  
enables protein binding PubMed 
enables protein serine/threonine kinase activator activity PubMed 
Items 1 - 25 of 76
Process Evidence Code Pubs
involved_in BMP signaling pathway  
involved_in BMP signaling pathway PubMed 
involved_in BMP signaling pathway PubMed 
involved_in BMP signaling pathway PubMed 
involved_in allantois development  
involved_in ameloblast differentiation  
involved_in axon guidance  
involved_in branching involved in salivary gland morphogenesis  
involved_in branching morphogenesis of an epithelial tube  
involved_in cardiac muscle tissue development  
involved_in cardiac septum morphogenesis  
involved_in cartilage development  
involved_in cellular response to BMP stimulus PubMed 
involved_in cellular response to hypoxia  
involved_in chorio-allantoic fusion  
involved_in dendrite development PubMed 
involved_in embryonic camera-type eye morphogenesis  
involved_in embryonic limb morphogenesis  
involved_in embryonic pattern specification  
involved_in embryonic skeletal joint morphogenesis  
involved_in endocardial cushion formation  
involved_in epithelial to mesenchymal transition PubMed 
involved_in heart trabecula morphogenesis  
involved_in hindbrain development  
involved_in mesenchymal cell apoptotic process involved in nephron morphogenesis  
involved_in mesenchymal cell differentiation PubMed 
involved_in mesenchyme development  
involved_in mesoderm formation  
involved_in mesonephros development PubMed 
involved_in metanephric mesenchymal cell proliferation involved in metanephros development  
involved_in metanephric mesenchyme morphogenesis  
involved_in metanephros development PubMed 
involved_in monocyte aggregation PubMed 
involved_in negative regulation of DNA-templated transcription PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity  
involved_in negative regulation of Notch signaling pathway  
involved_in negative regulation of cell cycle PubMed 
involved_in negative regulation of glomerular mesangial cell proliferation PubMed 
involved_in negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis  
involved_in negative regulation of mitotic nuclear division PubMed 
involved_in negative regulation of neurogenesis  
acts_upstream_of_or_within negative regulation of neuron differentiation PubMed 
involved_in negative regulation of non-canonical NF-kappaB signal transduction  
involved_in negative regulation of prostatic bud formation  
involved_in negative regulation of striated muscle cell apoptotic process  
involved_in nephrogenic mesenchyme morphogenesis  
involved_in neural fold elevation formation  
acts_upstream_of_or_within neuron projection morphogenesis PubMed 
involved_in odontogenesis of dentin-containing tooth  
involved_in osteoblast differentiation PubMed 
involved_in pericardium morphogenesis  
involved_in pharyngeal system development  
involved_in positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of SMAD protein signal transduction PubMed 
involved_in positive regulation of SMAD protein signal transduction PubMed 
involved_in positive regulation of apoptotic process  
involved_in positive regulation of bone mineralization PubMed 
involved_in positive regulation of brown fat cell differentiation PubMed 
involved_in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis  
involved_in positive regulation of dendrite development PubMed 
involved_in positive regulation of epithelial cell differentiation  
involved_in positive regulation of epithelial to mesenchymal transition  
involved_in positive regulation of gene expression PubMed 
involved_in positive regulation of heterotypic cell-cell adhesion PubMed 
involved_in positive regulation of hyaluranon cable assembly PubMed 
involved_in positive regulation of neuron differentiation  
involved_in positive regulation of osteoblast differentiation PubMed 
involved_in positive regulation of transcription by RNA polymerase II  
involved_in regulation of branching involved in prostate gland morphogenesis  
involved_in regulation of removal of superoxide radicals  
involved_in response to estradiol  
involved_in response to peptide hormone  
involved_in response to vitamin D  
involved_in skeletal system development PubMed 
involved_in ureteric bud development  
Items 1 - 25 of 76
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix  
located_in extracellular region  
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in vesicle  

General protein information

Preferred Names
bone morphogenetic protein 7
Names
osteogenic protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032771.1 RefSeqGene

    Range
    5011..102899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001719.3NP_001710.1  bone morphogenetic protein 7 preproprotein

    See identical proteins and their annotated locations for NP_001710.1

    Status: REVIEWED

    Source sequence(s)
    AK291186, AL157414, BM683430, DA740733
    Consensus CDS
    CCDS13455.1
    UniProtKB/Swiss-Prot
    P18075, Q9H512, Q9NTQ7
    UniProtKB/TrEMBL
    A8K571, B2ZPJ8
    Related
    ENSP00000379204.3, ENST00000395863.8
    Conserved Domains (2) summary
    pfam00688
    Location:35280
    TGFb_propeptide; TGF-beta propeptide
    cd19397
    Location:325431
    TGF_beta_BMP7; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    57168753..57266641 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    58946552..59044382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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