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Hnrnpd heterogeneous nuclear ribonucleoprotein D [ Rattus norvegicus (Norway rat) ]

Gene ID: 79256, updated on 9-Dec-2024

Summary

Official Symbol
Hnrnpdprovided by RGD
Official Full Name
heterogeneous nuclear ribonucleoprotein Dprovided by RGD
Primary source
RGD:620365
See related
EnsemblRapid:ENSRNOG00000002292 AllianceGenome:RGD:620365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Auf1; Hnrpd
Summary
Enables chromatin binding activity; histone deacetylase binding activity; and nucleic acid binding activity. Involved in several processes, including cellular response to estradiol stimulus; cellular response to nitric oxide; and regulation of gene expression. Is active in glutamatergic synapse and postsynaptic density. Used to study uremia. Biomarker of hepatocellular carcinoma. Orthologous to human HNRNPD (heterogeneous nuclear ribonucleoprotein D). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 207.5), Spleen (RPKM 202.0) and 9 other tissues See more
Orthologs
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Genomic context

See Hnrnpd in Genome Data Viewer
Location:
14p22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (9918630..9938072)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (9615375..9638975)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (11256163..11274684)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene enolase-phosphatase 1 Neighboring gene uncharacterized LOC134481708 Neighboring gene heterogeneous nuclear ribonucleoprotein D-like Neighboring gene histone chaperone ASF1A-like Neighboring gene transcription factor BTF3-like Neighboring gene vesicle-associated membrane protein 9 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding  
enables RNA binding  
enables RNA binding  
enables chromatin binding PubMed 
enables histone deacetylase binding PubMed 
enables mRNA 3'-UTR AU-rich region binding PubMed 
enables mRNA binding PubMed 
enables mRNA binding PubMed 
enables minor groove of adenine-thymine-rich DNA binding PubMed 
enables protein binding PubMed 
enables telomeric DNA binding  
enables telomeric DNA binding  
Items 1 - 25 of 30
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization PubMed 
involved_in CRD-mediated mRNA stabilization  
involved_in cellular response to amino acid stimulus PubMed 
involved_in cellular response to estradiol stimulus PubMed 
involved_in cellular response to nitric oxide PubMed 
involved_in cellular response to putrescine PubMed 
involved_in cerebellum development PubMed 
involved_in circadian regulation of translation  
involved_in circadian regulation of translation  
involved_in hepatocyte dedifferentiation PubMed 
involved_in liver development PubMed 
involved_in negative regulation of gene expression PubMed 
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
involved_in positive regulation of cytoplasmic translation  
involved_in positive regulation of gene expression PubMed 
acts_upstream_of positive regulation of telomere capping  
involved_in positive regulation of telomere maintenance via telomerase  
acts_upstream_of positive regulation of telomere maintenance via telomerase  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of translation  
involved_in positive regulation of translation  
involved_in regulation of circadian rhythm  
involved_in regulation of circadian rhythm  
involved_in regulation of gene expression  
acts_upstream_of_or_within regulation of mRNA stability  
involved_in response to calcium ion PubMed 
involved_in response to electrical stimulus PubMed 
involved_in response to estradiol PubMed 
involved_in response to rapamycin PubMed 
involved_in response to sodium phosphate PubMed 
Items 1 - 25 of 30
Component Evidence Code Pubs
located_in chromatin  
located_in cytosol  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
part_of mCRD-mediated mRNA stability complex  
is_active_in nucleoplasm  
located_in nucleoplasm  
is_active_in postsynaptic density PubMed 
is_active_in postsynaptic density PubMed 
part_of ribonucleoprotein complex  
part_of ribonucleoprotein complex  
is_active_in synapse  

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein D0
Names
AU-rich element RNA-binding factor 1
AU-rich element RNA-binding protein 1
RNA binding protein p45AUF1
hnRNP D0

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082539.1NP_001076008.1  heterogeneous nuclear ribonucleoprotein D0 isoform b

    See identical proteins and their annotated locations for NP_001076008.1

    Status: VALIDATED

    Source sequence(s)
    AB046616, CB798484, CO560068
    UniProtKB/TrEMBL
    A6K623
    Related
    ENSRNOP00000003173.4, ENSRNOT00000003173.9
    Conserved Domains (3) summary
    cd12575
    Location:78151
    RRM1_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP D0, hnRNP A/B, hnRNP DL and similar proteins
    cd12583
    Location:162236
    RRM2_hnRNPD; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
    pfam08143
    Location:5576
    CBFNT; CBFNT (NUC161) domain
  2. NM_001082540.1NP_001076009.1  heterogeneous nuclear ribonucleoprotein D0 isoform c

    See identical proteins and their annotated locations for NP_001076009.1

    Status: VALIDATED

    Source sequence(s)
    AB046617, CB798484, CO567918
    UniProtKB/TrEMBL
    A6K622
    Related
    ENSRNOP00000003158.4, ENSRNOT00000003158.8
    Conserved Domains (3) summary
    cd12575
    Location:97170
    RRM1_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP D0, hnRNP A/B, hnRNP DL and similar proteins
    cd12583
    Location:181255
    RRM2_hnRNPD; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
    pfam08143
    Location:5576
    CBFNT; CBFNT (NUC161) domain
  3. NM_001082541.1NP_001076010.1  heterogeneous nuclear ribonucleoprotein D0 isoform d

    See identical proteins and their annotated locations for NP_001076010.1

    Status: VALIDATED

    Source sequence(s)
    AB046618, CB798484, CO560068
    UniProtKB/TrEMBL
    A6K625
    Conserved Domains (3) summary
    cd12575
    Location:78151
    RRM1_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP D0, hnRNP A/B, hnRNP DL and similar proteins
    cd12583
    Location:162236
    RRM2_hnRNPD; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
    pfam08143
    Location:5576
    CBFNT; CBFNT (NUC161) domain
  4. NM_024404.2NP_077380.2  heterogeneous nuclear ribonucleoprotein D0 isoform a

    See identical proteins and their annotated locations for NP_077380.2

    Status: VALIDATED

    Source sequence(s)
    AB046615, CB798484, CO567918
    UniProtKB/Swiss-Prot
    G3V9G2, P17132, Q9JJ51, Q9JJ52, Q9JJ53, Q9JJ54
    Related
    ENSRNOP00000046491.2, ENSRNOT00000047840.7
    Conserved Domains (3) summary
    cd12575
    Location:97170
    RRM1_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP D0, hnRNP A/B, hnRNP DL and similar proteins
    cd12583
    Location:181255
    RRM2_hnRNPD; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
    pfam08143
    Location:5576
    CBFNT; CBFNT (NUC161) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    9918630..9938072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273661.1XP_063129731.1  heterogeneous nuclear ribonucleoprotein D0 isoform X1

    UniProtKB/TrEMBL
    A6K623

RNA

  1. XR_359351.4 RNA Sequence

  2. XR_005493015.2 RNA Sequence

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