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Nkx6-2 NK6 homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 14912, updated on 9-Dec-2024

Summary

Official Symbol
Nkx6-2provided by MGI
Official Full Name
NK6 homeobox 2provided by MGI
Primary source
MGI:MGI:1352738
See related
Ensembl:ENSMUSG00000041309 AllianceGenome:MGI:1352738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gtx; Nkx6.2
Summary
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Acts upstream of or within several processes, including central nervous system myelination; pancreatic A cell differentiation; and regulation of oligodendrocyte differentiation. Located in nucleus. Is expressed in several structures, including 4-cell stage embryo; central nervous system; gut; neural ectoderm; and thymus. Human ortholog(s) of this gene implicated in spastic ataxia 8. Orthologous to human NKX6-2 (NK6 homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in stomach adult (RPKM 18.8), cerebellum adult (RPKM 13.6) and 19 other tissues See more
Orthologs
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Genomic context

See Nkx6-2 in Genome Data Viewer
Location:
7 F4; 7 84.57 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139159292..139162726, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (139579376..139582797, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-5-phosphatase A Neighboring gene STARR-seq mESC enhancer starr_20423 Neighboring gene predicted gene, 53346 Neighboring gene VISTA enhancer mm1683 Neighboring gene glycosylated lysosomal membrane protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_20426 Neighboring gene STARR-seq mESC enhancer starr_20427 Neighboring gene predicted gene, 33031 Neighboring gene cilia and flagella associated protein 46 Neighboring gene STARR-positive B cell enhancer mm9_chr7:146833912-146834213 Neighboring gene STARR-seq mESC enhancer starr_20429 Neighboring gene NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (5)  1 citation

Interactions

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell differentiation  
acts_upstream_of cell fate commitment PubMed 
acts_upstream_of_or_within central nervous system myelination PubMed 
acts_upstream_of_or_within endocrine pancreas development PubMed 
acts_upstream_of_or_within negative regulation of cell fate commitment PubMed 
acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within neuromuscular process controlling balance PubMed 
acts_upstream_of neuron fate commitment PubMed 
acts_upstream_of oligodendrocyte differentiation PubMed 
acts_upstream_of_or_within oligodendrocyte differentiation PubMed 
acts_upstream_of_or_within pancreatic A cell differentiation PubMed 
acts_upstream_of_or_within positive regulation of cell fate commitment PubMed 
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation PubMed 
involved_in regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II PubMed 
Component Evidence Code Pubs
is_active_in nucleus  
located_in nucleus PubMed 
located_in nucleus  

General protein information

Preferred Names
homeobox protein Nkx-6.2
Names
Drosophila NK transcription factor related, gene family 6, locus 2
NK6 transcription factor related, locus 2
glial and testis specific homeobox

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183248.4NP_899071.2  homeobox protein Nkx-6.2

    See identical proteins and their annotated locations for NP_899071.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC112670
    Consensus CDS
    CCDS40170.1
    UniProtKB/TrEMBL
    D3Z4R4
    Related
    ENSMUSP00000101701.3, ENSMUST00000106095.3
    Conserved Domains (1) summary
    pfam00046
    Location:151205
    Homeobox; Homeobox domain

RNA

  1. NR_027857.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents a longer, spliced 3' UTR. This variant is represented as non-coding because the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC112670

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    139159292..139162726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152695.1XP_036008588.1  homeobox protein Nkx-6.2 isoform X1

    UniProtKB/TrEMBL
    D3Z4R4
    Related
    ENSMUSP00000095588.3, ENSMUST00000097974.9
    Conserved Domains (1) summary
    pfam00046
    Location:151205
    Homeobox; Homeobox domain
  2. XM_036152694.1XP_036008587.1  homeobox protein Nkx-6.2 isoform X1

    UniProtKB/TrEMBL
    D3Z4R4
    Conserved Domains (1) summary
    pfam00046
    Location:151205
    Homeobox; Homeobox domain
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