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Nsg2 neuronal vesicle trafficking associated 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 497878, updated on 9-Dec-2024

Summary

Official Symbol
Nsg2provided by RGD
Official Full Name
neuronal vesicle trafficking associated 2provided by RGD
Primary source
RGD:1563944
See related
AllianceGenome:RGD:1563944
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hmp19
Summary
Predicted to enable clathrin light chain binding activity. Predicted to be involved in clathrin coat assembly; endosomal transport; and regulation of postsynaptic membrane neurotransmitter receptor levels. Located in several cellular components, including endosome; lysosomal lumen; and trans-Golgi network membrane. Orthologous to human NSG2 (neuronal vesicle trafficking associated 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 1620.9), Adrenal (RPKM 134.1) and 1 other tissue See more
Orthologs
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Genomic context

See Nsg2 in Genome Data Viewer
Location:
10q12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (16106073..16165915, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (15601594..15661441, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15867885..15928169, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095054 Neighboring gene uncharacterized LOC108352067 Neighboring gene uncharacterized LOC120095056 Neighboring gene uncharacterized LOC134480766 Neighboring gene uncharacterized LOC120095055 Neighboring gene similar to human chromosome 5 open reading frame 47 Neighboring gene cytoplasmic polyadenylation element binding protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Clone Names

  • MGC125201

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables clathrin light chain binding  
enables clathrin light chain binding  
Process Evidence Code Pubs
involved_in clathrin coat assembly  
involved_in clathrin coat assembly  
involved_in endosomal transport  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels  
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in Golgi cis cisterna membrane  
located_in Golgi cis cisterna membrane  
located_in cytoplasmic vesicle membrane  
located_in cytoplasmic vesicle membrane  
located_in cytoplasmic vesicle membrane  
located_in dendrite PubMed 
located_in early endosome PubMed 
located_in early endosome membrane  
is_active_in endosome  
located_in endosome PubMed 
is_active_in glutamatergic synapse  
located_in late endosome PubMed 
located_in lysosomal lumen PubMed 
is_active_in membrane  
located_in multivesicular body membrane  
located_in multivesicular body membrane  
is_active_in postsynaptic density membrane  
located_in trans-Golgi network membrane PubMed 

General protein information

Preferred Names
neuronal vesicle trafficking-associated protein 2
Names
neuron specific gene family member 2
neuron-specific protein family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034152.1NP_001029324.1  neuronal vesicle trafficking-associated protein 2

    See identical proteins and their annotated locations for NP_001029324.1

    Status: PROVISIONAL

    Source sequence(s)
    BC105916
    UniProtKB/Swiss-Prot
    Q3KR51
    Conserved Domains (1) summary
    pfam06387
    Location:1166
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    16106073..16165915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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