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    CLC Charcot-Leyden crystal galectin [ Homo sapiens (human) ]

    Gene ID: 1178, updated on 10-Dec-2024

    Summary

    Official Symbol
    CLCprovided by HGNC
    Official Full Name
    Charcot-Leyden crystal galectinprovided by HGNC
    Primary source
    HGNC:HGNC:2014
    See related
    Ensembl:ENSG00000105205 MIM:153310; AllianceGenome:HGNC:2014
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GAL10; Gal-10; LGALS10; LGALS10A; LPPL_HUMAN
    Summary
    Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in bone marrow (RPKM 112.7), urinary bladder (RPKM 16.5) and 5 other tissues See more
    Orthologs
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    Genomic context

    See CLC in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39731255..39738029, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42535528..42542305, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40221895..40228669, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S29 pseudogene 27 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14629 Neighboring gene galectin 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14630 Neighboring gene leucine twenty homeobox Neighboring gene uncharacterized LOC124904719

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A comprehensive family-based replication study of schizophrenia genes.
    EBI GWAS Catalog

    Interactions

    General gene information

    Clone Names

    • MGC149659

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding  
    enables cysteine-type endopeptidase activity PubMed 
    enables identical protein binding PubMed 
    NOT contributes_to lysophospholipase activity PubMed 
    enables protein binding PubMed 

    General protein information

    Preferred Names
    galectin-10
    Names
    Charcot-Leyden crystal protein
    eosinophil lysophospholipase
    lectin, galactoside-binding, soluble, 10
    lysolecithin acylhydrolase
    NP_001819.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046978.1 RefSeqGene

      Range
      5001..11775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001828.6NP_001819.2  galectin-10

      See identical proteins and their annotated locations for NP_001819.2

      Status: REVIEWED

      Source sequence(s)
      AV715261, AV762486, AW292557
      Consensus CDS
      CCDS33025.1
      UniProtKB/Swiss-Prot
      C5HZ13, C5HZ14, Q05315, Q0VDE3
      Related
      ENSP00000221804.3, ENST00000221804.5
      Conserved Domains (1) summary
      pfam00337
      Location:5137
      Gal-bind_lectin; Galactoside-binding lectin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      39731255..39738029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      42535528..42542305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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