U.S. flag

An official website of the United States government

Vtcn1 V-set domain containing T cell activation inhibitor 1 [ Mus musculus (house mouse) ]

Gene ID: 242122, updated on 9-Dec-2024

Summary

Official Symbol
Vtcn1provided by MGI
Official Full Name
V-set domain containing T cell activation inhibitor 1provided by MGI
Primary source
MGI:MGI:3039619
See related
Ensembl:ENSMUSG00000051076 AllianceGenome:MGI:3039619
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B7x; B7h4; B7s1
Summary
Enables signaling receptor binding activity. Acts upstream of or within positive regulation of interleukin-2 production; regulation of T cell activation; and response to protozoan. Located in external side of plasma membrane. Is expressed in several structures, including hemolymphoid system gland; liver; lung; male reproductive gland or organ; and pancreas. Orthologous to human VTCN1 (V-set domain containing T cell activation inhibitor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 4.1), mammary gland adult (RPKM 2.4) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Vtcn1 in Genome Data Viewer
Location:
3 F2.2; 3 43.78 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (100732775..100805555)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (100825459..100896922)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08498 Neighboring gene STARR-positive B cell enhancer ABC_E3455 Neighboring gene predicted gene 43464 Neighboring gene STARR-seq mESC enhancer starr_08501 Neighboring gene predicted gene, 40107 Neighboring gene predicted gene, 32720 Neighboring gene STARR-positive B cell enhancer ABC_E232 Neighboring gene predicted gene, 40108 Neighboring gene tripartite motif-containing 45

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (10) 
  • Targeted (6)  1 citation

General gene information

Clone Names

  • MGC41287

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor binding  
enables signaling receptor binding PubMed 
enables signaling receptor binding PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway  
involved_in adaptive immune response  
acts_upstream_of_or_within interleukin-4 production PubMed 
acts_upstream_of_or_within negative regulation of T cell activation PubMed 
involved_in negative regulation of T cell activation  
involved_in negative regulation of T cell proliferation  
involved_in negative regulation of T cell proliferation  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of apoptotic process  
acts_upstream_of_or_within positive regulation of T cell proliferation PubMed 
acts_upstream_of_or_within positive regulation of interleukin-2 production PubMed 
involved_in regulation of cytokine production  
acts_upstream_of_or_within response to protozoan PubMed 
acts_upstream_of_or_within type II interferon production PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane  
located_in external side of plasma membrane PubMed 
located_in external side of plasma membrane  

General protein information

Preferred Names
V-set domain containing T-cell activation inhibitor 1
Names
B7 homolog 4
immune costimulatory protein B7-H4
t cell costimulatory molecule B7x

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409755.1NP_001396684.1  V-set domain containing T-cell activation inhibitor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL669872, AL691436
  2. NM_001409758.1NP_001396687.1  V-set domain containing T-cell activation inhibitor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL669872
  3. NM_178594.4NP_848709.2  V-set domain containing T-cell activation inhibitor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_848709.2

    Status: VALIDATED

    Source sequence(s)
    AL669872, AL691436
    Consensus CDS
    CCDS17677.1
    UniProtKB/Swiss-Prot
    Q7TPH5, Q7TSP5, Q8K091
    Related
    ENSMUSP00000057721.8, ENSMUST00000054791.9
    Conserved Domains (2) summary
    smart00410
    Location:46144
    IG_like; Immunoglobulin like
    cl11960
    Location:49146
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    100732775..100805555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.