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    SREBF1 sterol regulatory element binding transcription factor 1 [ Homo sapiens (human) ]

    Gene ID: 6720, updated on 10-Dec-2024

    Summary

    Official Symbol
    SREBF1provided by HGNC
    Official Full Name
    sterol regulatory element binding transcription factor 1provided by HGNC
    Primary source
    HGNC:HGNC:11289
    See related
    Ensembl:ENSG00000072310 MIM:184756; AllianceGenome:HGNC:11289
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HMD; IFAP2; SREBP1; bHLHd1
    Summary
    This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]
    Expression
    Ubiquitous expression in fat (RPKM 35.7), adrenal (RPKM 34.6) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SREBF1 in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (17811334..17836986, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (17757927..17783669, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (17714648..17740300, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene retinoic acid induced 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17665979-17666591 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17666592-17667203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11810 Neighboring gene uncharacterized LOC124903942 Neighboring gene RAI1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17682070-17682959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17683849-17684738 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:17685874-17686374 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17687340-17687880 Neighboring gene Sharpr-MPRA regulatory region 10806 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:17693241-17693447 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17696322-17697048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17697049-17697773 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17704013-17704802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17704803-17705590 Neighboring gene Sharpr-MPRA regulatory region 10333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8256 Neighboring gene Smith-Magenis syndrome chromosome region, candidate 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17716071-17716629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17722069-17722789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11811 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:17726733-17726883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11813 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17730461-17731182 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17731183-17731904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17733682-17734430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17734431-17735178 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17739175-17740076 Neighboring gene microRNA 6777 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17740077-17740979 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:17740980-17741881 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17743523-17744042 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8261 Neighboring gene microRNA 33b Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17745179-17745680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17747581-17748101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17751860-17752706 Neighboring gene Sharpr-MPRA regulatory region 7387 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:17762139-17762639 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11815 Neighboring gene target of myb1 like 2 membrane trafficking protein Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:17779053-17780252 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17780613-17781334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17787373-17788134 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17788135-17788894 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17792123-17792624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11817 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17817644-17818266 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17823655-17824188 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17824189-17824722 Neighboring gene Sharpr-MPRA regulatory region 12990 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17825257-17825790 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17825791-17826324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17826325-17826857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11818 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17875207-17875776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11819 Neighboring gene uncharacterized LOC107984989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17884370-17884870 Neighboring gene brain protein I3 pseudogene 3 Neighboring gene dynein regulatory complex subunit 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Hereditary mucoepithelial dysplasia
    MedGen: C1274795 OMIM: 158310 GeneReviews: Not available
    Compare labs
    IFAP syndrome 2
    MedGen: C5436607 OMIM: 619016 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    matrix gag HIV-1 MA increases SREBF1 mRNA expression in HepG2 cells and praimary hepatocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding PubMed 
    enables chromatin binding  
    enables nuclear receptor activity PubMed 
    enables protein binding PubMed 
    enables protein dimerization activity  
    enables protein kinase binding  
    enables protein-containing complex binding  
    enables sequence-specific double-stranded DNA binding PubMed 
    enables sterol response element binding PubMed 
    enables transcription coregulator binding PubMed 
    Items 1 - 25 of 44
    Process Evidence Code Pubs
    involved_in SREBP signaling pathway PubMed 
    involved_in SREBP signaling pathway PubMed 
    involved_in cellular response to fatty acid  
    involved_in cellular response to starvation PubMed 
    involved_in cholesterol biosynthetic process  
    involved_in circadian rhythm  
    involved_in fat cell differentiation  
    involved_in insulin receptor signaling pathway  
    involved_in insulin secretion  
    involved_in intracellular receptor signaling pathway  
    involved_in lipid biosynthetic process PubMed 
    involved_in lipid biosynthetic process  
    involved_in lipid metabolic process PubMed 
    involved_in lung development  
    involved_in mRNA transcription by RNA polymerase II  
    involved_in negative regulation of insulin secretion  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of negative regulation of triglyceride metabolic process PubMed 
    involved_in positive regulation of cholesterol biosynthetic process PubMed 
    involved_in positive regulation of cholesterol biosynthetic process PubMed 
    involved_in positive regulation of miRNA transcription PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of triglyceride biosynthetic process  
    involved_in regulation of fatty acid metabolic process  
    involved_in regulation of heart rate by chemical signal  
    involved_in regulation of lipid storage  
    involved_in regulation of mitophagy PubMed 
    involved_in regulation of protein stability PubMed 
    involved_in regulation of protein targeting to mitochondrion PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II PubMed 
    involved_in response to cAMP  
    involved_in response to ethanol  
    involved_in response to food  
    involved_in response to fructose  
    involved_in response to glucagon  
    involved_in response to glucose  
    involved_in response to nutrient  
    involved_in response to progesterone  
    involved_in response to retinoic acid  
    involved_in response to xenobiotic stimulus  
    Items 1 - 25 of 44
    Component Evidence Code Pubs
    located_in ER to Golgi transport vesicle membrane  
    located_in Golgi membrane  
    located_in chromatin  
    located_in cytoplasm  
    located_in cytosol  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum membrane  
    located_in nuclear envelope PubMed 
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    part_of protein-containing complex  

    General protein information

    Preferred Names
    sterol regulatory element-binding protein 1
    Names
    class D basic helix-loop-helix protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029029.1 RefSeqGene

      Range
      5026..30678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001005291.3NP_001005291.1  sterol regulatory element-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001005291.1

      Status: REVIEWED

      Source sequence(s)
      AC122129, BC026962, BC057388, BC063281, BQ025047
      Consensus CDS
      CCDS32583.1
      UniProtKB/TrEMBL
      B3KR77
      Related
      ENSP00000348069.4, ENST00000355815.8
      Conserved Domains (2) summary
      cd00083
      Location:351408
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam17040
      Location:156356
      CBP_CCPA; Cellulose-complementing protein A
    2. NM_001321096.3NP_001308025.1  sterol regulatory element-binding protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC122129, AK091131, BE208013, DA113045, DB084001
      UniProtKB/TrEMBL
      B3KR77
      Conserved Domains (2) summary
      cd00083
      Location:297354
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam17040
      Location:102302
      CBP_CCPA; Cellulose-complementing protein A
    3. NM_001388385.1NP_001375314.1  sterol regulatory element-binding protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC122129
      UniProtKB/TrEMBL
      B3KR77
      Conserved Domains (3) summary
      pfam05109
      Location:49320
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd18921
      Location:319393
      bHLHzip_SREBP1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 1 (SREBP1) and similar proteins
      pfam03154
      Location:87210
      Atrophin-1; Atrophin-1 family
    4. NM_001388386.1NP_001375315.1  sterol regulatory element-binding protein 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC122129
      UniProtKB/TrEMBL
      B3KR77
      Related
      ENSP00000379106.2, ENST00000395757.6
      Conserved Domains (3) summary
      pfam05109
      Location:49320
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd18921
      Location:319393
      bHLHzip_SREBP1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 1 (SREBP1) and similar proteins
      pfam03154
      Location:87210
      Atrophin-1; Atrophin-1 family
    5. NM_001388387.1NP_001375316.1  sterol regulatory element-binding protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC122129
      UniProtKB/TrEMBL
      B3KR77
      Conserved Domains (3) summary
      pfam05109
      Location:49320
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd18921
      Location:319393
      bHLHzip_SREBP1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 1 (SREBP1) and similar proteins
      pfam03154
      Location:87210
      Atrophin-1; Atrophin-1 family
    6. NM_001388388.1NP_001375317.1  sterol regulatory element-binding protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC122129
      UniProtKB/TrEMBL
      B3KR77
      Conserved Domains (3) summary
      pfam05109
      Location:49320
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam03154
      Location:87210
      Atrophin-1; Atrophin-1 family
      cl00081
      Location:319378
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    7. NM_001388389.1NP_001375318.1  sterol regulatory element-binding protein 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC122129
      UniProtKB/TrEMBL
      B3KR77
      Conserved Domains (2) summary
      cd18921
      Location:317391
      bHLHzip_SREBP1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 1 (SREBP1) and similar proteins
      pfam03154
      Location:87210
      Atrophin-1; Atrophin-1 family
    8. NM_001388390.1NP_001375319.1  sterol regulatory element-binding protein 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC122129
      UniProtKB/TrEMBL
      B3KR77
      Conserved Domains (3) summary
      pfam05109
      Location:49320
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd18921
      Location:319387
      bHLHzip_SREBP1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 1 (SREBP1) and similar proteins
      pfam03154
      Location:87210
      Atrophin-1; Atrophin-1 family
    9. NM_001388391.1NP_001375320.1  sterol regulatory element-binding protein 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC122129
      UniProtKB/TrEMBL
      B3KR77
      Conserved Domains (3) summary
      pfam05109
      Location:49320
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd18921
      Location:319384
      bHLHzip_SREBP1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 1 (SREBP1) and similar proteins
      pfam03154
      Location:87210
      Atrophin-1; Atrophin-1 family
    10. NM_001388392.1NP_001375321.1  sterol regulatory element-binding protein 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC122129
      UniProtKB/TrEMBL
      B3KR77
      Conserved Domains (2) summary
      pfam03154
      Location:87210
      Atrophin-1; Atrophin-1 family
      cl00081
      Location:267319
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    11. NM_001388393.1NP_001375322.1  sterol regulatory element-binding protein 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC122129
      UniProtKB/TrEMBL
      B3KR77
      Conserved Domains (3) summary
      pfam05109
      Location:49320
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd18921
      Location:319393
      bHLHzip_SREBP1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 1 (SREBP1) and similar proteins
      pfam03154
      Location:87210
      Atrophin-1; Atrophin-1 family
    12. NM_001388394.1NP_001375323.1  sterol regulatory element-binding protein 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC122129
      UniProtKB/TrEMBL
      B3KXZ7
      Conserved Domains (1) summary
      cd18921
      Location:175249
      bHLHzip_SREBP1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 1 (SREBP1) and similar proteins
    13. NM_004176.5NP_004167.3  sterol regulatory element-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_004167.3

      Status: REVIEWED

      Source sequence(s)
      AC122129, BC026962, BC057388, BC063281, BQ025047
      Consensus CDS
      CCDS11189.1
      UniProtKB/Swiss-Prot
      B0I4X3, B0I4X4, D3DXC4, P36956, Q16062, Q59F52, Q6P4R7, Q6PFW7, Q6PJ36, Q8TAK9
      UniProtKB/TrEMBL
      B3KR77
      Related
      ENSP00000261646.5, ENST00000261646.11
      Conserved Domains (3) summary
      cd00083
      Location:321378
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cl25496
      Location:49320
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl27975
      Location:87212
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

    RNA

    1. NR_170943.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC122129
    2. NR_170944.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC122129
    3. NR_170945.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC122129
    4. NR_170990.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC122129

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      17811334..17836986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436580.1XP_047292536.1  sterol regulatory element-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      B3KR77
    2. XM_047436581.1XP_047292537.1  sterol regulatory element-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      B3KR77

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      17757927..17783669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316989.1XP_054172964.1  sterol regulatory element-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      B3KR77
    2. XM_054316990.1XP_054172965.1  sterol regulatory element-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      B3KR77
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