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Syt4 synaptotagmin 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64440, updated on 9-Dec-2024

Summary

Official Symbol
Syt4provided by RGD
Official Full Name
synaptotagmin 4provided by RGD
Primary source
RGD:68397
See related
EnsemblRapid:ENSRNOG00000017333 AllianceGenome:RGD:68397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables several functions, including phosphatidylserine binding activity; protein dimerization activity; and syntaxin binding activity. Involved in several processes, including dense core granule cytoskeletal transport; negative regulation of transport; and vesicle organization. Located in several cellular components, including astrocyte projection; neuronal cell body; and secretory vesicle. Biomarker of visual epilepsy. Orthologous to human SYT4 (synaptotagmin 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward (RPKM 381.5) See more
Orthologs
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Genomic context

See Syt4 in Genome Data Viewer
Location:
18p12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (23311454..23320863, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (23036973..23046380, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (24172580..24181989, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene Ras-like without CAAX 2 Neighboring gene uncharacterized LOC120098263 Neighboring gene uncharacterized LOC120098253 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene actin, beta, pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNARE binding  
enables SNARE binding PubMed 
enables SNARE binding PubMed 
NOT enables calcium ion binding PubMed 
enables calcium ion binding  
enables calcium ion sensor activity  
NOT enables calcium-dependent phospholipid binding PubMed 
enables calcium-dependent phospholipid binding  
enables clathrin binding PubMed 
NOT enables phosphatidylserine binding PubMed 
enables phosphatidylserine binding PubMed 
NOT enables phospholipid binding PubMed 
enables protein binding PubMed 
enables protein heterodimerization activity PubMed 
enables protein homodimerization activity PubMed 
NOT enables syntaxin binding PubMed 
enables syntaxin binding PubMed 
enables syntaxin-1 binding PubMed 
enables syntaxin-3 binding PubMed 
Items 1 - 25 of 34
Process Evidence Code Pubs
involved_in calcium-dependent activation of synaptic vesicle fusion  
involved_in calcium-ion regulated exocytosis PubMed 
involved_in cell differentiation  
involved_in dense core granule cytoskeletal transport PubMed 
involved_in dense core granule cytoskeletal transport  
involved_in memory  
involved_in negative regulation of calcium ion-dependent exocytosis PubMed 
involved_in negative regulation of catecholamine secretion PubMed 
involved_in negative regulation of catecholamine secretion  
involved_in negative regulation of dense core granule exocytosis PubMed 
involved_in negative regulation of neurotransmitter secretion PubMed 
involved_in negative regulation of protein secretion  
involved_in negative regulation of retrograde trans-synaptic signaling by neuropeptide  
involved_in negative regulation of short-term neuronal synaptic plasticity  
involved_in negative regulation of synaptic vesicle exocytosis  
involved_in negative regulation of vesicle fusion PubMed 
acts_upstream_of_or_within neurotransmitter secretion  
involved_in neurotransmitter secretion PubMed 
involved_in positive regulation of dendrite extension  
involved_in positive regulation of dense core granule exocytosis  
involved_in positive regulation of glutamate secretion  
involved_in regulation of calcium ion-dependent exocytosis  
involved_in regulation of calcium ion-dependent exocytosis  
involved_in regulation of dopamine secretion  
involved_in regulation of endocytosis PubMed 
involved_in regulation of endocytosis  
involved_in regulation of postsynaptic dense core vesicle exocytosis  
involved_in regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission  
involved_in regulation of vesicle fusion PubMed 
involved_in regulation of vesicle fusion  
involved_in secretory granule maturation PubMed 
involved_in vesicle fusion  
involved_in vesicle fusion with vesicle PubMed 
involved_in vesicle-mediated transport  
Items 1 - 25 of 34
Items 1 - 20 of 34
Component Evidence Code Pubs
located_in Golgi apparatus PubMed 
located_in Golgi apparatus  
located_in astrocyte projection PubMed 
located_in astrocyte projection  
is_active_in axon  
located_in axon PubMed 
located_in axon  
located_in dendrite  
located_in dense core granule PubMed 
located_in dense core granule  
is_active_in exocytic vesicle  
located_in exocytic vesicle PubMed 
is_active_in glutamatergic synapse  
located_in membrane  
located_in membrane PubMed 
located_in microvesicle  
located_in neuron projection PubMed 
located_in neuron projection  
located_in neuron projection terminus PubMed 
located_in neuronal cell body PubMed 
located_in neuronal cell body  
located_in neuronal dense core vesicle PubMed 
located_in neuronal dense core vesicle membrane PubMed 
is_active_in neuronal dense core vesicle membrane  
located_in perinuclear region of cytoplasm  
is_active_in plasma membrane  
located_in plasma membrane  
located_in secretory granule membrane PubMed 
located_in somatodendritic compartment  
is_active_in synapse  
located_in synaptic vesicle PubMed 
NOT located_in synaptic vesicle  
located_in synaptic vesicle PubMed 
located_in vesicle  
Items 1 - 20 of 34

General protein information

Preferred Names
synaptotagmin-4
Names
synaptotagmin IV
sytIV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031693.2NP_113881.1  synaptotagmin-4

    See identical proteins and their annotated locations for NP_113881.1

    Status: VALIDATED

    Source sequence(s)
    BG666223, CB730279, CB786178, JAXUCZ010000018, U14398
    UniProtKB/Swiss-Prot
    P50232
    UniProtKB/TrEMBL
    A6J2N4, Q3S2E5
    Related
    ENSRNOP00000023593.4, ENSRNOT00000023594.7
    Conserved Domains (2) summary
    cd08388
    Location:153279
    C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
    cd08404
    Location:288423
    C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    23311454..23320863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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