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    Cldn11 claudin 11 [ Mus musculus (house mouse) ]

    Gene ID: 18417, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cldn11provided by MGI
    Official Full Name
    claudin 11provided by MGI
    Primary source
    MGI:MGI:106925
    See related
    Ensembl:ENSMUSG00000037625 AllianceGenome:MGI:106925
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Osp; Otm; Claudin11; Claudin-11
    Summary
    This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of CNS (central nervous system) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. The basal cell tight junctions in stria vascularis are primarily composed of this protein, and the gene-null mice suffer severe deafness. This protein is also an obligatory protein for tight junction formation and barrier integrity in the testis and the gene deficiency results in loss of the Sertoli cell epithelial phenotype in the testis. [provided by RefSeq, Aug 2010]
    Expression
    Biased expression in cerebellum adult (RPKM 80.9), cortex adult (RPKM 73.0) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Cldn11 in Genome Data Viewer
    Location:
    3 A3; 3 15.14 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (31204069..31218475)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (31149920..31164326)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07312 Neighboring gene STARR-positive B cell enhancer ABC_E9544 Neighboring gene STARR-positive B cell enhancer ABC_E2067 Neighboring gene predicted gene, 33641 Neighboring gene predicted gene, 33694 Neighboring gene STARR-seq mESC enhancer starr_07316 Neighboring gene STARR-positive B cell enhancer ABC_E9545 Neighboring gene SKI-like Neighboring gene STARR-seq mESC enhancer starr_07318 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 14 Neighboring gene STARR-seq mESC enhancer starr_07319 Neighboring gene predicted gene 15496 Neighboring gene STARR-seq mESC enhancer starr_07320 Neighboring gene STARR-seq mESC enhancer starr_07321 Neighboring gene STARR-seq mESC enhancer starr_07322 Neighboring gene STARR-seq mESC enhancer starr_07323 Neighboring gene STARR-seq mESC enhancer starr_07324 Neighboring gene STARR-seq mESC enhancer starr_07325 Neighboring gene STARR-seq mESC enhancer starr_07326 Neighboring gene predicted gene, 54171

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (3)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding  
    enables identical protein binding  
    enables protein binding PubMed 
    enables structural molecule activity  
    Component Evidence Code Pubs
    located_in axon  
    located_in axon  
    located_in basal part of cell PubMed 
    is_active_in bicellular tight junction  
    located_in bicellular tight junction PubMed 
    located_in bicellular tight junction  
    located_in bicellular tight junction PubMed 
    located_in cell junction  
    located_in lipid droplet  
    located_in lipid droplet  
    located_in myelin sheath PubMed 
    located_in neurofilament  
    located_in neurofilament  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in tight junction PubMed 
    located_in tight junction  

    General protein information

    Preferred Names
    claudin-11
    Names
    oligodendrocyte transmembrane protein
    oligodendrocyte-specific protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008770.3NP_032796.1  claudin-11

      See identical proteins and their annotated locations for NP_032796.1

      Status: REVIEWED

      Source sequence(s)
      AK005088, BB798247, BY110541
      Consensus CDS
      CCDS17290.1
      UniProtKB/Swiss-Prot
      Q545N5, Q60771, Q9DB65
      Related
      ENSMUSP00000042181.7, ENSMUST00000046174.8
      Conserved Domains (1) summary
      cl21598
      Location:6172
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      31204069..31218475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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