Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Envelope surface glycoprotein gp120
|
env
|
Activated granulocytes and macrophages producing hypochlorite/hypochlorous acid-altered isolated proteins antithrombin III and human serum albumin bind to gp120 and inhibit viral proliferation |
PubMed
|
|
env
|
Binding of 3-hydroxyphthalic anhydride-modified human serum albumin to HIV-1 gp120 or CD4 inhibits HIV-1 entry into target cells |
PubMed
|
|
env
|
Inhibition of HIV-1 binding to CD4 by suramin is reversed by human albumin, suggesting that only free suramin has antiviral properties |
PubMed
|
|
env
|
The negatively charged succinylated and aconitylated albumins bind to the V3 loop (amino acids 296-330) and the C-terminal part of HIV-1 gp120 and do not interact directly with the HIV chemokine receptors CXCR4 and CCR5 |
PubMed
|
|
env
|
The inhibition of HIV-1 gp120 binding to cells by succinylated human serum albumin is reversed by heparin |
PubMed
|
Envelope transmembrane glycoprotein gp41
|
env
|
N-terminal gp41 peptide binds as an alpha helix (residues 519-536) to fatty acid sites on human serum albumin (HSA) |
PubMed
|
|
env
|
The lysis of erythrocytes induced by the amino-terminal peptide (residues 519-541) of HIV-1 gp41 is blocked by anti-(518-541) IgG, dextran sulfate, and anionic albumins |
PubMed
|
Tat
|
tat
|
HIV-1 Tat increases albumin permeability in isolated human glomeruli |
PubMed
|
|
tat
|
HIV-1 Tat induces a dose-dependent flux of albumin through endothelial cell monolayers, an effect involving Tat activation of the VEGF receptor type 2 and MAP kinase |
PubMed
|
Go to the HIV-1, Human Interaction Database