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LATS2 large tumor suppressor kinase 2 [ Homo sapiens (human) ]

Gene ID: 26524, updated on 10-Dec-2024

Summary

Official Symbol
LATS2provided by HGNC
Official Full Name
large tumor suppressor kinase 2provided by HGNC
Primary source
HGNC:HGNC:6515
See related
Ensembl:ENSG00000150457 MIM:604861; AllianceGenome:HGNC:6515
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KPM
Summary
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 10.9), gall bladder (RPKM 10.1) and 25 other tissues See more
Orthologs
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Genomic context

See LATS2 in Genome Data Viewer
Location:
13q12.11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (20973036..21061586, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (20166164..20254674, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21547175..21635725, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene ribosomal protein SA pseudogene 54 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:21549761-21550262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21571219-21571758 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21572540-21573076 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:21608126-21608626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21609627-21610451 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21611543-21612531 Neighboring gene RNA, U4 small nuclear 9, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:21624857-21625356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:21626645-21627146 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21634192-21635084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5160 Neighboring gene uncharacterized LOC105370104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:21649238-21649738 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:21649739-21650239 Neighboring gene ribosomal protein S12 pseudogene 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ13161

Gene Ontology Provided by GOA

Items 1 - 25 of 27
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding PubMed 
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables metal ion binding  
enables protein binding PubMed 
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity PubMed 
enables protein serine/threonine kinase activity  
enables ribosomal protein S6 kinase activity  
Items 1 - 25 of 27
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle  
involved_in G1/S transition of mitotic cell cycle PubMed 
involved_in canonical Wnt signaling pathway  
involved_in cell division  
involved_in chromatin remodeling  
involved_in hippo signaling  
involved_in hippo signaling PubMed 
involved_in hippo signaling  
involved_in hormone-mediated signaling pathway PubMed 
involved_in inner cell mass cell fate commitment  
involved_in inner cell mass cellular morphogenesis  
involved_in intracellular signal transduction PubMed 
involved_in keratinocyte differentiation  
involved_in negative regulation of canonical Wnt signaling pathway PubMed 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity PubMed 
involved_in negative regulation of protein localization to nucleus  
involved_in positive regulation of NLRP3 inflammasome complex assembly PubMed 
involved_in positive regulation of apoptotic process  
involved_in protein localization  
involved_in protein phosphorylation PubMed 
involved_in regulation of organ growth  
involved_in regulation of transforming growth factor beta receptor signaling pathway  
Component Evidence Code Pubs
located_in centriolar satellite  
is_active_in cytoplasm PubMed 
located_in cytosol PubMed 
located_in cytosol  
is_active_in nucleus  
located_in nucleus PubMed 
located_in nucleus PubMed 
is_active_in spindle pole  
located_in spindle pole PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase LATS2
Names
LATS (large tumor suppressor, Drosophila) homolog 2
LATS, large tumor suppressor, homolog 2
kinase phosphorylated during mitosis protein
large tumor suppressor homolog 2
serine/threonine kinase KPM
serine/threonine-protein kinase kpm
warts-like kinase
NP_055387.2
XP_005266399.1
XP_011533344.1
XP_016876030.1
XP_016876031.1
XP_047286222.1
XP_047286223.1
XP_054230417.1
XP_054230418.1
XP_054230419.1
XP_054230420.1
XP_054230421.1
XP_054230422.1
XP_054230423.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014572.3NP_055387.2  serine/threonine-protein kinase LATS2

    See identical proteins and their annotated locations for NP_055387.2

    Status: REVIEWED

    Source sequence(s)
    AF207547, AL161613, AL356285, BQ774580, DB452765
    Consensus CDS
    CCDS9294.1
    UniProtKB/Swiss-Prot
    B1AM47, Q9NRM7, Q9P2X1
    UniProtKB/TrEMBL
    Q59EB4
    Related
    ENSP00000372035.4, ENST00000382592.5
    Conserved Domains (3) summary
    cd05626
    Location:6661046
    STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
    smart00220
    Location:668973
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14398
    Location:101141
    UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    20973036..21061586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020542.2XP_016876031.1  serine/threonine-protein kinase LATS2 isoform X4

    UniProtKB/TrEMBL
    Q59EB4
  2. XM_005266342.1XP_005266399.1  serine/threonine-protein kinase LATS2 isoform X1

    See identical proteins and their annotated locations for XP_005266399.1

    UniProtKB/Swiss-Prot
    B1AM47, Q9NRM7, Q9P2X1
    UniProtKB/TrEMBL
    Q59EB4
    Conserved Domains (3) summary
    cd05626
    Location:6661046
    STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
    smart00220
    Location:668973
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14398
    Location:101141
    UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2
  3. XM_047430266.1XP_047286222.1  serine/threonine-protein kinase LATS2 isoform X1

    UniProtKB/Swiss-Prot
    B1AM47, Q9NRM7, Q9P2X1
    UniProtKB/TrEMBL
    Q59EB4
  4. XM_047430267.1XP_047286223.1  serine/threonine-protein kinase LATS2 isoform X4

    UniProtKB/TrEMBL
    Q59EB4
  5. XM_017020541.2XP_016876030.1  serine/threonine-protein kinase LATS2 isoform X3

    UniProtKB/TrEMBL
    Q59EB4
  6. XM_011535042.3XP_011533344.1  serine/threonine-protein kinase LATS2 isoform X2

    Conserved Domains (3) summary
    cd05626
    Location:579959
    STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
    smart00220
    Location:581886
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21463
    Location:2454
    UBA_like_SF; UBA domain-like superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    20166164..20254674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374447.1XP_054230422.1  serine/threonine-protein kinase LATS2 isoform X4

    UniProtKB/TrEMBL
    Q59EB4
  2. XM_054374443.1XP_054230418.1  serine/threonine-protein kinase LATS2 isoform X1

    UniProtKB/TrEMBL
    Q59EB4
  3. XM_054374444.1XP_054230419.1  serine/threonine-protein kinase LATS2 isoform X1

    UniProtKB/TrEMBL
    Q59EB4
  4. XM_054374448.1XP_054230423.1  serine/threonine-protein kinase LATS2 isoform X4

    UniProtKB/TrEMBL
    Q59EB4
  5. XM_054374442.1XP_054230417.1  serine/threonine-protein kinase LATS2 isoform X1

    UniProtKB/TrEMBL
    Q59EB4
  6. XM_054374446.1XP_054230421.1  serine/threonine-protein kinase LATS2 isoform X3

    UniProtKB/TrEMBL
    Q59EB4
  7. XM_054374445.1XP_054230420.1  serine/threonine-protein kinase LATS2 isoform X2

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