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    hif-1 Hypoxia-inducible factor 1;PAS domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180359, updated on 9-Dec-2024

    Summary

    Official Symbol
    hif-1
    Official Full Name
    Hypoxia-inducible factor 1;PAS domain-containing protein
    Primary source
    WormBase:WBGene00001851
    Locus tag
    CELE_F38A6.3
    See related
    AllianceGenome:WB:WBGene00001851
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription factor activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including cellular response to caloric restriction; determination of adult lifespan; and heat acclimation. Located in nucleus. Is expressed widely. Used to study cancer and cardiovascular system disease. Human ortholog(s) of this gene implicated in familial erythrocytosis 4; lung non-small cell carcinoma; polycythemia; and pulmonary hypertension. Orthologous to human EPAS1 (endothelial PAS domain protein 1) and HIF3A (hypoxia inducible factor 3 subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See hif-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (20780407..20785260)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Echinoderm microtubule-associated protein-like elp-1;HELP domain-containing protein Neighboring gene DUF19 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Antitoxin Neighboring gene Brinker DNA-binding domain-containing protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in apoptotic process  
    involved_in cellular response to caloric restriction PubMed 
    involved_in cellular response to hypoxia  
    involved_in determination of adult lifespan PubMed 
    involved_in determination of adult lifespan PubMed 
    involved_in heat acclimation PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in phosphorelay signal transduction system  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II PubMed 
    involved_in response to axon injury PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to hypoxia PubMed 
    Component Evidence Code Pubs
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    Hypoxia-inducible factor 1;PAS domain-containing protein
    NP_001023891.2
    • Confirmed by transcript evidence
    NP_001023892.1
    • Partially confirmed by transcript evidence
    NP_001023894.2
    • Confirmed by transcript evidence
    NP_001299994.1
    • Confirmed by transcript evidence
    NP_001359648.1
    • Partially confirmed by transcript evidence
    NP_508008.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20780407..20785260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028720.5NP_001023891.2  Hypoxia-inducible factor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023891.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGD2
      Conserved Domains (3) summary
      cd00083
      Location:1066
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:94145
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:236338
      PAS_11; PAS domain
    2. NM_001373210.2NP_001359648.1  Hypoxia-inducible factor 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      smart00091
      Location:89142
      PAS; PAS domain
      pfam14598
      Location:236338
      PAS_11; PAS domain
      cl00081
      Location:1266
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    3. NM_075607.8NP_508008.4  Hypoxia-inducible factor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508008.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECE6, G5EDZ3, G5EE28, G5EGD2, Q8I4D0
      Conserved Domains (3) summary
      cd00083
      Location:1066
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:94145
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:236338
      PAS_11; PAS domain
    4. NM_001313065.3NP_001299994.1  PAS domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AXG6
      Conserved Domains (3) summary
      cd00083
      Location:258
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:86137
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:228330
      PAS_11; PAS domain
    5. NM_001028723.4NP_001023894.2  Hypoxia-inducible factor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023894.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGD2
      Conserved Domains (3) summary
      cd00083
      Location:258
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:86137
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:228330
      PAS_11; PAS domain
    6. NM_001028721.6NP_001023892.1  Hypoxia-inducible factor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023892.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGD2
      Conserved Domains (2) summary
      cd00130
      Location:1796
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:20122
      PAS_11; PAS domain
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