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    ARF5 ARF GTPase 5 [ Homo sapiens (human) ]

    Gene ID: 381, updated on 10-Dec-2024

    Summary

    Official Symbol
    ARF5provided by HGNC
    Official Full Name
    ARF GTPase 5provided by HGNC
    Primary source
    HGNC:HGNC:658
    See related
    Ensembl:ENSG00000004059 MIM:103188; AllianceGenome:HGNC:658
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. [provided by RefSeq, Dec 2010]
    Expression
    Ubiquitous expression in esophagus (RPKM 84.6), skin (RPKM 63.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ARF5 in Genome Data Viewer
    Location:
    7q32.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (127588411..127591700)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (128900090..128903379)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (127228465..127231754)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 3012 Neighboring gene uncharacterized LOC105375490 Neighboring gene VISTA enhancer hs1308 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:127223080-127224279 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:127224999-127225998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:127227286-127227912 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr7:127227913-127228538 and GRCh37_chr7:127228539-127229165 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:127229166-127229791 Neighboring gene uncharacterized LOC105375489 Neighboring gene GRIP and coiled-coil domain containing 1 Neighboring gene fascin actin-bundling protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:127249495-127249995 Neighboring gene PAX4 5' regulatory region Neighboring gene paired box 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ADP-ribosylation factor 5 (ARF5), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ADP-ribosylation factor 5 (ARF5), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify ADP-ribosylation factor 5 (ARF5), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ADP-ribosylation factor 5 (ARF5), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Potential readthrough

    Included gene: FSCN3

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTP binding  
    enables GTPase activity  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    is_active_in cytoplasm  
    located_in extracellular exosome PubMed 
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    ADP-ribosylation factor 5
    Names
    ADP ribosylation factor 5
    NP_001653.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001662.4NP_001653.1  ADP-ribosylation factor 5

      See identical proteins and their annotated locations for NP_001653.1

      Status: REVIEWED

      Source sequence(s)
      AC000357
      Consensus CDS
      CCDS34745.1
      UniProtKB/Swiss-Prot
      P26437, P84085
      UniProtKB/TrEMBL
      A4D0Z3, C9J1Z8
      Related
      ENSP00000000233.5, ENST00000000233.10
      Conserved Domains (1) summary
      cl40481
      Location:1180
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      127588411..127591700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      128900090..128903379
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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