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    Sh3pxd2a SH3 and PX domains 2A [ Mus musculus (house mouse) ]

    Gene ID: 14218, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sh3pxd2aprovided by MGI
    Official Full Name
    SH3 and PX domains 2Aprovided by MGI
    Primary source
    MGI:MGI:1298393
    See related
    Ensembl:ENSMUSG00000053617 AllianceGenome:MGI:1298393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fish; TSK5; Tks5; Gm5098; Sh3md1; EG329070; C230050L11; 2310014D11Rik
    Summary
    Enables phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and protease binding activity. Involved in reactive oxygen species metabolic process. Acts upstream of or within in utero embryonic development. Located in cytoplasm and podosome. Is expressed in several structures, including brain; clavicle; liver; skeletal muscle; and spleen. Orthologous to human SH3PXD2A (SH3 and PX domains 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 33.7), mammary gland adult (RPKM 26.4) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Sh3pxd2a in Genome Data Viewer
    Location:
    19 C3; 19 39.45 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47248613..47453053, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47260174..47464612, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene H1.11 linker histone, pseudogene Neighboring gene STARR-seq mESC enhancer starr_46341 Neighboring gene neuralized E3 ubiquitin protein ligase 1A Neighboring gene predicted gene, 36693 Neighboring gene STARR-seq mESC enhancer starr_46347 Neighboring gene microRNA 6995 Neighboring gene VISTA enhancer mm1098 Neighboring gene predicted gene, 29834 Neighboring gene STARR-positive B cell enhancer ABC_E8755 Neighboring gene STARR-seq mESC enhancer starr_46356 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:47487651-47487834 Neighboring gene STARR-positive B cell enhancer ABC_E7669 Neighboring gene STARR-positive B cell enhancer ABC_E4289 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:47523086-47523301 Neighboring gene STARR-seq mESC enhancer starr_46360 Neighboring gene predicted gene, 36885 Neighboring gene predicted gene, 52384 Neighboring gene STARR-seq mESC enhancer starr_46363 Neighboring gene predicted gene, 41858 Neighboring gene predicted gene, 19557 Neighboring gene STN1, CST complex subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC144076, MGC190848, MGC190948

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within in utero embryonic development PubMed 
    involved_in osteoclast fusion  
    involved_in osteoclast fusion  
    involved_in reactive oxygen species metabolic process PubMed 
    involved_in superoxide anion generation  
    involved_in superoxide metabolic process  
    involved_in superoxide metabolic process  
    Component Evidence Code Pubs
    located_in anchoring junction  
    located_in cell projection  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in podosome PubMed 
    located_in podosome  
    located_in podosome  

    General protein information

    Preferred Names
    SH3 and PX domain-containing protein 2A
    Names
    SH3 multiple domains 1
    SH3 multiple domains protein 1
    five SH3 domain-containing protein
    five SH3 domains
    tyrosine kinase substrate with five SH3 domains

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164717.2NP_001158189.1  SH3 and PX domain-containing protein 2A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC132268, AC132288
      Consensus CDS
      CCDS50464.1
      UniProtKB/TrEMBL
      A0A494BBI9
      Related
      ENSMUSP00000107430.3, ENSMUST00000111800.4
      Conserved Domains (6) summary
      cd06888
      Location:6124
      PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein
      cd12019
      Location:810860
      SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12020
      Location:10391095
      SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12074
      Location:170222
      SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12077
      Location:241294
      SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12079
      Location:422475
      SH3_Tks5_3; Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    2. NM_008018.5NP_032044.2  SH3 and PX domain-containing protein 2A isoform 1

      See identical proteins and their annotated locations for NP_032044.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC132268, AC132288
      Consensus CDS
      CCDS29891.1
      UniProtKB/Swiss-Prot
      E9QKJ2, O89032, Q148Q8
      UniProtKB/TrEMBL
      A0A494BBI9
      Related
      ENSMUSP00000080325.3, ENSMUST00000081619.10
      Conserved Domains (6) summary
      cd06888
      Location:6124
      PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein
      cd12019
      Location:838888
      SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12020
      Location:10671123
      SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12074
      Location:170222
      SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12077
      Location:269322
      SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12079
      Location:450503
      SH3_Tks5_3; Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      47248613..47453053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161432.1XP_036017325.1  SH3 and PX domain-containing protein 2A isoform X2

      UniProtKB/TrEMBL
      A0A494BBI9
      Conserved Domains (6) summary
      cd06888
      Location:6124
      PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein
      cd12019
      Location:795845
      SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12020
      Location:10241080
      SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12074
      Location:155207
      SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12077
      Location:226279
      SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12079
      Location:407460
      SH3_Tks5_3; Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    2. XM_006526669.5XP_006526732.1  SH3 and PX domain-containing protein 2A isoform X1

      UniProtKB/TrEMBL
      A0A494BBI9
      Conserved Domains (6) summary
      cd06888
      Location:6124
      PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein
      cd12019
      Location:823873
      SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12020
      Location:10521108
      SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12074
      Location:155207
      SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12077
      Location:254307
      SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12079
      Location:435488
      SH3_Tks5_3; Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    3. XM_006526670.5XP_006526733.1  SH3 and PX domain-containing protein 2A isoform X3

      Conserved Domains (3) summary
      cd12019
      Location:368418
      SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12020
      Location:597653
      SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cl17036
      Location:433
      SH3; Src Homology 3 domain superfamily

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