Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Envelope surface glycoprotein gp120
|
env
|
HIV-1 gp120 upregulates the expression of indoleamine-pyrrole 2,3 dioxygenase (INDO) in human B cells |
PubMed
|
|
env
|
CCR5- or CXCR4-tropic HIV-1 induce the release of Indoleamine 2,3-dioxygenase (IDO) in plasmacytoid dendritic cells and this induction is inhibited by the blockade of HIV-1 gp120 interaction with CD4 by anti-CD4-Ab |
PubMed
|
Tat
|
tat
|
HIV-1 and the viral protein Tat modulate the expression of indoleamine-pyrrole 2,3 dioxygenase (IDO1) in immature dendritic cells and monocyte-derived macrophages |
PubMed
|
|
tat
|
HIV-1 clade B Tat up-regulates IDO and down-regulates serotonin transporter (5-HTT) gene and protein expressions in immature dendritic cells |
PubMed
|
|
tat
|
HIV-1 Tat-treated human monocyte derived-dendritic cells inhibit CD4+ T cell proliferation in an IDO dependent mechanism |
PubMed
|
|
tat
|
HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells |
PubMed
|
|
tat
|
HIV-1 Tat upregulates indoleamine-pyrrole 2,3 dioxygenase (IDO1) expression in Jurkat T-cells |
PubMed
|
|
tat
|
HIV-1 Tat upregulates the expression of indoleamine-pyrrole 2,3 dioxygenase (IDO) mRNA in monocytes. The synthesis of IDO is greatly reduced in the presence of neutralizing anti-TNF antibodies |
PubMed
|
Vpr
|
vpr
|
HIV-1 Vpr potentiates the suppression of indoleamine 2,3-dioxygenase by glucocorticoids via the glucocorticoid receptor pathway |
PubMed
|
Go to the HIV-1, Human Interaction Database