U.S. flag

An official website of the United States government

ZNF684 zinc finger protein 684 [ Homo sapiens (human) ]

Gene ID: 127396, updated on 10-Dec-2024

Summary

Official Symbol
ZNF684provided by HGNC
Official Full Name
zinc finger protein 684provided by HGNC
Primary source
HGNC:HGNC:28418
See related
Ensembl:ENSG00000117010 AllianceGenome:HGNC:28418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within innate immune response and negative regulation of single stranded viral RNA replication via double stranded DNA intermediate. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in kidney (RPKM 1.9), liver (RPKM 1.8) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZNF684 in Genome Data Viewer
Location:
1p34.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (40531637..40548167)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (40400805..40417330)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40997309..41013839)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 847 Neighboring gene exonuclease 5 Neighboring gene uncharacterized LOC124904149 Neighboring gene Sharpr-MPRA regulatory region 98 Neighboring gene eukaryotic translation initiation factor 2 subunit gamma pseudogene Neighboring gene uncharacterized LOC105378673

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

General gene information

Clone Names

  • MGC27466

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in nucleus  

General protein information

Preferred Names
zinc finger protein 684
Names
hypothetical protein MGC27466

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152373.4NP_689586.3  zinc finger protein 684

    See identical proteins and their annotated locations for NP_689586.3

    Status: VALIDATED

    Source sequence(s)
    AK094072, BC111463, BG116229
    Consensus CDS
    CCDS454.1
    UniProtKB/Swiss-Prot
    Q2NKY4, Q5T5D7
    Related
    ENSP00000361784.3, ENST00000372699.8
    Conserved Domains (6) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:185345
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:187209
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:341366
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    40531637..40548167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    40400805..40417330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.