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Snap23 synaptosomal-associated protein 23 [ Mus musculus (house mouse) ]

Gene ID: 20619, updated on 12-Dec-2024

Summary

Official Symbol
Snap23provided by MGI
Official Full Name
synaptosomal-associated protein 23provided by MGI
Primary source
MGI:MGI:109356
See related
Ensembl:ENSMUSG00000027287 AllianceGenome:MGI:109356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sndt; 23kDa; Syndet; SNAP-23
Summary
Predicted to enable SNAP receptor activity and syntaxin-1 binding activity. Acts upstream of or within exocytosis. Located in cytoplasmic vesicle and plasma membrane. Part of SNARE complex. Is expressed in cerebral cortex ventricular layer; cortical plate; and testis. Orthologous to human SNAP23 (synaptosome associated protein 23). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in placenta adult (RPKM 10.3), bladder adult (RPKM 8.3) and 24 other tissues See more
Orthologs
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Genomic context

See Snap23 in Genome Data Viewer
Location:
2 60.37 cM; 2 E5
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120398137..120436829)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120567655..120601255)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931402G19 gene Neighboring gene STARR-seq mESC enhancer starr_05508 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120308865-120309066 Neighboring gene calpain 3 Neighboring gene STARR-seq mESC enhancer starr_05509 Neighboring gene zinc finger protein 106 Neighboring gene STARR-seq mESC enhancer starr_05510 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120393240-120393349 Neighboring gene STARR-seq mESC enhancer starr_05511 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120435029-120435138 Neighboring gene STARR-seq mESC enhancer starr_05512 Neighboring gene leucine rich repeat containing 57 Neighboring gene STARR-positive B cell enhancer ABC_E414 Neighboring gene HAUS augmin-like complex, subunit 2 Neighboring gene StAR related lipid transfer domain containing 9 Neighboring gene STARR-seq mESC enhancer starr_05514 Neighboring gene codanin 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity  
enables SNAP receptor activity  
enables protein binding PubMed 
enables syntaxin binding  
enables syntaxin binding  
Process Evidence Code Pubs
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane  
involved_in exocytosis  
acts_upstream_of_or_within exocytosis PubMed 
involved_in histamine secretion by mast cell  
involved_in membrane fusion  
involved_in protein transport  
involved_in protein-containing complex assembly  
involved_in regulation of exocytosis  
involved_in synaptic vesicle fusion to presynaptic active zone membrane  
involved_in synaptic vesicle priming  
involved_in vesicle-mediated transport  
involved_in vesicle-mediated transport in synapse  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse  
part_of SNARE complex  
part_of SNARE complex PubMed 
part_of SNARE complex  
located_in adherens junction  
located_in azurophil granule  
located_in cytoplasm  
located_in cytoplasmic vesicle PubMed 
is_active_in glutamatergic synapse  
located_in mitochondrion  
located_in neuron projection  
located_in nucleoplasm  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in plasma membrane  
is_active_in postsynapse  
located_in specific granule  
located_in synapse  

General protein information

Preferred Names
synaptosomal-associated protein 23
Names
synaptosomal-associated protein, 23kD
vesicle-membrane fusion protein SNAP-23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177792.2NP_001171263.1  synaptosomal-associated protein 23 isoform a

    See identical proteins and their annotated locations for NP_001171263.1

    Status: VALIDATED

    Source sequence(s)
    AL772299
    Consensus CDS
    CCDS50681.1
    UniProtKB/TrEMBL
    Q9D3L3
    Related
    ENSMUSP00000112138.2, ENSMUST00000116437.8
    Conserved Domains (3) summary
    cd15884
    Location:159217
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cd15895
    Location:975
    SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
    pfam00835
    Location:100157
    SNAP-25; SNAP-25 family
  2. NM_001177793.2NP_001171264.1  synaptosomal-associated protein 23 isoform b

    See identical proteins and their annotated locations for NP_001171264.1

    Status: VALIDATED

    Source sequence(s)
    AL772299
    Consensus CDS
    CCDS16622.1
    UniProtKB/Swiss-Prot
    O09044, O35620
    UniProtKB/TrEMBL
    A2AKH4
    Related
    ENSMUSP00000028743.4, ENSMUST00000028743.10
    Conserved Domains (3) summary
    cd15884
    Location:148206
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cd15895
    Location:975
    SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
    pfam00835
    Location:86146
    SNAP-25; SNAP-25 family
  3. NM_001412626.1NP_001399555.1  synaptosomal-associated protein 23 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL772299
    UniProtKB/Swiss-Prot
    O09044, O35620
    UniProtKB/TrEMBL
    A2AKH4
  4. NM_001412627.1NP_001399556.1  synaptosomal-associated protein 23 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL772299
    UniProtKB/Swiss-Prot
    O09044, O35620
    UniProtKB/TrEMBL
    A2AKH4
  5. NM_001412628.1NP_001399557.1  synaptosomal-associated protein 23 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL772299
  6. NM_001412629.1NP_001399558.1  synaptosomal-associated protein 23 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL772299
  7. NM_001412630.1NP_001399559.1  synaptosomal-associated protein 23 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL772299
    UniProtKB/TrEMBL
    B0R030
    Related
    ENSMUSP00000116935.2, ENSMUST00000142278.2
  8. NM_001412631.1NP_001399560.1  synaptosomal-associated protein 23 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL772299
  9. NM_001412632.1NP_001399561.1  synaptosomal-associated protein 23 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL772299
  10. NM_001412633.1NP_001399562.1  synaptosomal-associated protein 23 isoform i

    Status: VALIDATED

    Source sequence(s)
    AL772299
  11. NM_009222.4NP_033248.1  synaptosomal-associated protein 23 isoform b

    See identical proteins and their annotated locations for NP_033248.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame, exon, compared to variant 1. Variants 2 and 3 encode the same protein (isoform b).
    Source sequence(s)
    AL772299
    Consensus CDS
    CCDS16622.1
    UniProtKB/Swiss-Prot
    O09044, O35620
    UniProtKB/TrEMBL
    A2AKH4
    Related
    ENSMUSP00000106339.3, ENSMUST00000110711.9
    Conserved Domains (3) summary
    cd15884
    Location:148206
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cd15895
    Location:975
    SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
    pfam00835
    Location:86146
    SNAP-25; SNAP-25 family

RNA

  1. NR_182010.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299
  2. NR_182011.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299
  3. NR_182012.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299
  4. NR_182013.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299
  5. NR_182014.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299
  6. NR_182015.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299
  7. NR_182016.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    120398137..120436829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499056.5XP_006499119.1  synaptosomal-associated protein 23 isoform X1

    See identical proteins and their annotated locations for XP_006499119.1

    UniProtKB/TrEMBL
    Q9D3L3
    Conserved Domains (3) summary
    cd15884
    Location:159217
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cd15895
    Location:975
    SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
    pfam00835
    Location:100157
    SNAP-25; SNAP-25 family
  2. XM_006499054.5XP_006499117.1  synaptosomal-associated protein 23 isoform X1

    See identical proteins and their annotated locations for XP_006499117.1

    UniProtKB/TrEMBL
    Q9D3L3
    Conserved Domains (3) summary
    cd15884
    Location:159217
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cd15895
    Location:975
    SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
    pfam00835
    Location:100157
    SNAP-25; SNAP-25 family
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