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    Nudt1 nudix hydrolase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117260, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nudt1provided by RGD
    Official Full Name
    nudix hydrolase 1provided by RGD
    Primary source
    RGD:621080
    See related
    EnsemblRapid:ENSRNOG00000001260 AllianceGenome:RGD:621080
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mth1
    Summary
    Predicted to enable nucleoside triphosphate diphosphatase activity and snoRNA binding activity. Involved in male gonad development and response to cadmium ion. Located in acrosomal vesicle; extracellular space; and nuclear membrane. Biomarker of hypertension. Orthologous to human NUDT1 (nudix hydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 66.6), Spleen (RPKM 34.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nudt1 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19416411..19423448, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (14302514..14309559, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16391578..16398771, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352425 Neighboring gene eukaryotic translation initiation factor 3, subunit B Neighboring gene sorting nexin 8 Neighboring gene mitotic arrest deficient 1 like 1 Neighboring gene mitochondrial rRNA methyltransferase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2-hydroxy-ATP hydrolase activity  
    enables 2-hydroxy-ATP hydrolase activity  
    enables 2-hydroxy-dATP hydrolase activity  
    enables 2-hydroxy-dATP hydrolase activity  
    NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity  
    NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity  
    enables 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity  
    enables 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity  
    enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity  
    enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity  
    enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity  
    enables ATP diphosphatase activity  
    enables N6-methyl-(d)ATP hydrolase activity  
    enables O6-methyl-dGTP hydrolase activity  
    enables dATP diphosphatase activity  
    enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides  
    enables metal ion binding  
    enables snoRNA binding  
    enables snoRNA binding  
    Process Evidence Code Pubs
    involved_in DNA protection  
    involved_in DNA protection  
    involved_in DNA protection  
    involved_in male gonad development PubMed 
    involved_in purine nucleoside catabolic process  
    involved_in purine nucleoside catabolic process  
    involved_in response to cadmium ion PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in extracellular space PubMed 
    located_in mitochondrial matrix  
    located_in mitochondrial matrix  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in nuclear membrane PubMed 
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    oxidized purine nucleoside triphosphate hydrolase
    Names
    2-hydroxy-dATP diphosphatase
    7,8-dihydro-8-oxoguanine triphosphatase
    8-oxo-dGTPase
    methylated purine nucleoside triphosphate hydrolase
    mutT human homolog (8-oxo-dGTPase)
    nucleoside diphosphate-linked moiety X motif 1
    nudix (nucleoside diphosphate linked moiety X)-type motif 1
    nudix motif 1
    nudix-type motif 1
    NP_476461.1
    XP_006248973.1
    XP_038944963.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057120.2NP_476461.1  oxidized purine nucleoside triphosphate hydrolase

      See identical proteins and their annotated locations for NP_476461.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      P53369
      UniProtKB/TrEMBL
      A6K1T0
      Related
      ENSRNOP00000001700.5, ENSRNOT00000001700.8
      Conserved Domains (1) summary
      cd03427
      Location:6140
      MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      19416411..19423448 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248911.5XP_006248973.1  oxidized purine nucleoside triphosphate hydrolase isoform X1

      See identical proteins and their annotated locations for XP_006248973.1

      UniProtKB/Swiss-Prot
      P53369
      UniProtKB/TrEMBL
      A6K1T0
      Conserved Domains (1) summary
      cd03427
      Location:6140
      MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...
    2. XM_039089035.2XP_038944963.1  oxidized purine nucleoside triphosphate hydrolase isoform X1

      UniProtKB/Swiss-Prot
      P53369
      UniProtKB/TrEMBL
      A6K1T0
      Conserved Domains (1) summary
      cd03427
      Location:6140
      MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...
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