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    DHRS7 dehydrogenase/reductase 7 [ Homo sapiens (human) ]

    Gene ID: 51635, updated on 10-Dec-2024

    Summary

    Official Symbol
    DHRS7provided by HGNC
    Official Full Name
    dehydrogenase/reductase 7provided by HGNC
    Primary source
    HGNC:HGNC:21524
    See related
    Ensembl:ENSG00000100612 MIM:612833; AllianceGenome:HGNC:21524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGI-86; SDR34C1; retDSR4; retSDR4
    Summary
    This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. [provided by RefSeq, Apr 2016]
    Expression
    Broad expression in prostate (RPKM 116.8), small intestine (RPKM 40.2) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DHRS7 in Genome Data Viewer
    Location:
    14q23.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (60144119..60169889, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (54350401..54376186, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (60610837..60636607, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60124167-60124668 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60124669-60125168 Neighboring gene reticulon 1 Neighboring gene microRNA 5586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5807 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:60386022-60387221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8464 Neighboring gene leucine rich repeat containing 9 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:60459076-60459307 Neighboring gene PCNX4 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8466 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60558835-60559468 Neighboring gene Sharpr-MPRA regulatory region 1153 Neighboring gene pecanex 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8470 Neighboring gene short coiled-coil protein pseudogene 1 Neighboring gene proteasome subunit alpha 3 pseudogene 1 Neighboring gene ribosomal protein L17 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.
    EBI GWAS Catalog

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane PubMed 
    located_in membrane PubMed 

    General protein information

    Preferred Names
    dehydrogenase/reductase SDR family member 7
    Names
    dehydrogenase/reductase (SDR family) member 7
    retinal short-chain dehydrogenase/reductase 4
    short chain dehydrogenase/reductase family 34C member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001322280.2NP_001309209.1  dehydrogenase/reductase SDR family member 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL163853
      Consensus CDS
      CCDS81810.1
      UniProtKB/Swiss-Prot
      Q9Y394
      Related
      ENSP00000442993.2, ENST00000536410.6
      Conserved Domains (1) summary
      cd05332
      Location:2258
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    2. NM_001322281.2NP_001309210.1  dehydrogenase/reductase SDR family member 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL163853
      Conserved Domains (1) summary
      cl21454
      Location:1168
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. NM_001322282.2NP_001309211.1  dehydrogenase/reductase SDR family member 7 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AL163853
      Conserved Domains (1) summary
      cl21454
      Location:48228
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    4. NM_016029.4NP_057113.1  dehydrogenase/reductase SDR family member 7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_057113.1

      Status: VALIDATED

      Source sequence(s)
      AL163853
      Consensus CDS
      CCDS9743.1
      UniProtKB/Swiss-Prot
      B2R896, Q9UKU2, Q9Y394
      UniProtKB/TrEMBL
      Q659E8
      Related
      ENSP00000451882.1, ENST00000557185.6
      Conserved Domains (1) summary
      cd05332
      Location:48308
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      60144119..60169889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      54350401..54376186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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