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Pls1 plastin 1 (I-isoform) [ Mus musculus (house mouse) ]

Gene ID: 102502, updated on 9-Dec-2024

Summary

Official Symbol
Pls1provided by MGI
Official Full Name
plastin 1 (I-isoform)provided by MGI
Primary source
MGI:MGI:104809
See related
Ensembl:ENSMUSG00000049493 AllianceGenome:MGI:104809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable actin filament binding activity. Involved in several processes, including inner ear receptor cell stereocilium organization; intestinal D-glucose absorption; and positive regulation of protein localization to plasma membrane. Acts upstream of or within terminal web assembly. Located in brush border; stereocilium; and terminal web. Is expressed in egg cylinder; female reproductive system; and gut. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 76. Orthologous to human PLS1 (plastin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in large intestine adult (RPKM 58.4), small intestine adult (RPKM 19.6) and 4 other tissues See more
Orthologs
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Genomic context

See Pls1 in Genome Data Viewer
Location:
9 E3.3; 9 50.22 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (95634695..95727359, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (95752642..95845306, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene procollagen C-endopeptidase enhancer 2 Neighboring gene inosine triphosphatase (nucleoside triphosphate pyrophosphatase) pseudogene 2 Neighboring gene predicted gene, 39407 Neighboring gene transient receptor potential cation channel, subfamily C, member 1 Neighboring gene VISTA enhancer mm1367 Neighboring gene RIKEN cDNA 1700065D16 gene Neighboring gene STARR-positive B cell enhancer ABC_E5095 Neighboring gene STARR-positive B cell enhancer ABC_E894 Neighboring gene STARR-positive B cell enhancer mm9_chr9:95758941-95759242 Neighboring gene ataxia telangiectasia and Rad3 related Neighboring gene STARR-seq mESC enhancer starr_24939 Neighboring gene predicted gene, 24004

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding  
enables actin filament binding  
enables calcium ion binding  
enables protein binding PubMed 
Component Evidence Code Pubs
is_active_in actin filament  
is_active_in actin filament bundle  
located_in brush border PubMed 
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytosol  
located_in cytosol  
located_in plasma membrane  
located_in plasma membrane  
located_in stereocilium PubMed 
located_in terminal web PubMed 

General protein information

Preferred Names
plastin-1
Names
I-fimbrin
plastin 1, I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033210.4NP_001028382.1  plastin-1

    See identical proteins and their annotated locations for NP_001028382.1

    Status: VALIDATED

    Source sequence(s)
    AC091531
    Consensus CDS
    CCDS23412.1
    UniProtKB/Swiss-Prot
    Q3V0K9
    Related
    ENSMUSP00000091317.3, ENSMUST00000093800.9
    Conserved Domains (1) summary
    COG5069
    Location:13622
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
  2. NM_001433803.1NP_001420732.1  plastin-1

    Status: VALIDATED

    Source sequence(s)
    AC091531
    UniProtKB/Swiss-Prot
    Q3V0K9
  3. NM_001433804.1NP_001420733.1  plastin-1

    Status: VALIDATED

    Source sequence(s)
    AC091531
    UniProtKB/Swiss-Prot
    Q3V0K9
  4. NM_001433805.1NP_001420734.1  plastin-1

    Status: VALIDATED

    Source sequence(s)
    AC091531
    UniProtKB/Swiss-Prot
    Q3V0K9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    95634695..95727359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510748.1XP_006510811.1  plastin-1 isoform X2

    Conserved Domains (1) summary
    COG5069
    Location:27543
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
  2. XM_006510746.4XP_006510809.1  plastin-1 isoform X1

    Conserved Domains (1) summary
    COG5069
    Location:13622
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
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