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fhl1b four and a half LIM domains 1b [ Danio rerio (zebrafish) ]

Gene ID: 387528, updated on 9-Dec-2024

Summary

Official Symbol
fhl1bprovided by ZNC
Official Full Name
four and a half LIM domains 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-031219-1
See related
Ensembl:ENSDARG00000056653 AllianceGenome:ZFIN:ZDB-GENE-031219-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fhl; cb1039
Summary
Predicted to enable transmembrane transporter binding activity. Acts upstream of or within several processes, including endocrine pancreas development; liver development; and pancreas regeneration. Is expressed in several structures, including cardiovascular system; digestive system; hypochord; liver primordium; and musculature system. Human ortholog(s) of this gene implicated in Uruguay faciocardiomusculoskeletal syndrome; X-linked Emery-Dreifuss muscular dystrophy 6; reducing body myopathy 1A; and reducing body myopathy 1B. Orthologous to human FHL1 (four and a half LIM domains 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See fhl1b in Genome Data Viewer
Location:
chromosome: 10
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (26598078..26620943)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (26636365..26659230)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene synaptojanin 1 Neighboring gene solute carrier family 9 member 6b Neighboring gene adhesion G-protein coupled receptor G6-like Neighboring gene HIV-1 Tat specific factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding  
enables transmembrane transporter binding  

General protein information

Preferred Names
four and a half LIM domains protein 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199217.1NP_954687.1  four and a half LIM domains protein 1b

    See identical proteins and their annotated locations for NP_954687.1

    Status: PROVISIONAL

    Source sequence(s)
    BC053279
    UniProtKB/TrEMBL
    Q7T327
    Related
    ENSDARP00000073643.4, ENSDART00000079187.6
    Conserved Domains (4) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:217280
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    26598078..26620943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009305310.4XP_009303585.1  four and a half LIM domains protein 1b isoform X1

    UniProtKB/TrEMBL
    A0A8M3AWS1, F1Q7A2
    Conserved Domains (4) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:217280
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
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