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cltca clathrin, heavy chain a (Hc) [ Danio rerio (zebrafish) ]

Gene ID: 323579, updated on 9-Dec-2024

Summary

Official Symbol
cltcaprovided by ZNC
Official Full Name
clathrin, heavy chain a (Hc)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2299
See related
Ensembl:ENSDARG00000043493 AllianceGenome:ZFIN:ZDB-GENE-030131-2299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cltc; cb1033; wu:fc03e11; wu:fc49a11; wu:fd07f02
Summary
Predicted to enable clathrin light chain binding activity. Predicted to be involved in clathrin coat assembly; mitotic cell cycle; and receptor-mediated endocytosis. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in clathrin-coated pit and cytoplasmic vesicle. Predicted to be part of clathrin complex. Predicted to be active in clathrin-coated endocytic vesicle and spindle. Is expressed in axial vasculature; blood; intermediate cell mass of mesoderm; notochord; and ventral mesoderm. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 56. Orthologous to human CLTC (clathrin heavy chain). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See cltca in Genome Data Viewer
Location:
chromosome: 10
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (28311016..28368972, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (28424391..28482353, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108191486 Neighboring gene peptidyl-tRNA hydrolase 2 Neighboring gene uncharacterized LOC101882864 Neighboring gene B-cell translocation gene 3

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables clathrin light chain binding  
enables structural molecule activity  
Component Evidence Code Pubs
part_of clathrin coat of coated pit  
part_of clathrin coat of trans-Golgi network vesicle  
part_of clathrin complex  
located_in clathrin-coated pit  
located_in cytoplasmic vesicle  
located_in membrane  

General protein information

Preferred Names
clathrin, heavy chain a (Hc)
Names
clathrin, heavy polypeptide a (Hc)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005391.2NP_001005391.2  clathrin, heavy chain a (Hc)

    Status: VALIDATED

    Source sequence(s)
    AY648777, BC163714, CR392341, EB769086
    UniProtKB/TrEMBL
    A0A8M1N2E2, A0A8M2BJY0, B3DK43, F1R966
    Related
    ENSDARP00000063848.4, ENSDART00000063849.5
    Conserved Domains (5) summary
    smart00299
    Location:12741416
    CLH; Clathrin heavy chain repeat homology
    pfam00637
    Location:14271564
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:198234
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331353
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:364421
    Clathrin_H_link; Clathrin-H-link

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    28311016..28368972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394789.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    50403..108768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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