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    Rpa1 replication protein A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287524, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rpa1provided by RGD
    Official Full Name
    replication protein A1provided by RGD
    Primary source
    RGD:1307376
    See related
    EnsemblRapid:ENSRNOG00000003123 AllianceGenome:RGD:1307376
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cb1-727
    Summary
    Enables single-stranded DNA binding activity. Predicted to be involved in DNA metabolic process; meiotic cell cycle; and protein localization to site of double-strand break. Predicted to act upstream of or within several processes, including homeostasis of number of cells within a tissue; in utero embryonic development; and positive regulation of cell population proliferation. Part of DNA replication factor A complex. Orthologous to human RPA1 (replication protein A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 385.9), Heart (RPKM 209.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rpa1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (60647185..60698279, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (60148869..60199970, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (62140419..62191518, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene reticulon 4 receptor-like 1 Neighboring gene uncharacterized LOC120095264 Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene F-box protein 5, pseudogene 1 Neighboring gene ribosomal protein L37, pseudogene 4 Neighboring gene SET and MYND domain containing 4 Neighboring gene serpin family F member 1

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-rich strand telomeric DNA binding  
    enables chromatin binding  
    enables chromatin-protein adaptor activity  
    enables damaged DNA binding  
    enables damaged DNA binding  
    enables metal ion binding  
    enables single-stranded DNA binding PubMed 
    enables single-stranded DNA binding  
    enables single-stranded telomeric DNA binding  
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA repair  
    involved_in DNA replication PubMed 
    involved_in DNA replication  
    involved_in DNA unwinding involved in DNA replication  
    involved_in base-excision repair  
    involved_in chromatin organization  
    acts_upstream_of_or_within chromosome organization  
    involved_in double-strand break repair via homologous recombination  
    acts_upstream_of_or_within double-strand break repair via homologous recombination  
    involved_in double-strand break repair via homologous recombination  
    acts_upstream_of_or_within hemopoiesis  
    acts_upstream_of_or_within homeostasis of number of cells within a tissue  
    acts_upstream_of_or_within in utero embryonic development  
    involved_in meiotic cell cycle  
    acts_upstream_of_or_within meiotic cell cycle  
    involved_in mismatch repair  
    involved_in nucleotide-excision repair  
    involved_in nucleotide-excision repair  
    acts_upstream_of_or_within positive regulation of cell population proliferation  
    involved_in protein localization to chromosome  
    involved_in protein localization to site of double-strand break  
    involved_in telomere maintenance  
    involved_in telomere maintenance via telomerase  
    Component Evidence Code Pubs
    part_of DNA replication factor A complex  
    part_of DNA replication factor A complex PubMed 
    part_of DNA replication factor A complex  
    located_in PML body  
    located_in condensed chromosome  
    located_in condensed nuclear chromosome  
    located_in lateral element  
    located_in male germ cell nucleus  
    located_in nucleoplasm  
    located_in nucleus  
    located_in site of DNA damage  
    is_active_in site of double-strand break  

    General protein information

    Preferred Names
    replication protein A 70 kDa DNA-binding subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394069.1NP_001380998.1  replication protein A 70 kDa DNA-binding subunit

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2KAT3
      Related
      ENSRNOP00000078632.1, ENSRNOT00000116502.2
      Conserved Domains (1) summary
      TIGR00617
      Location:2612
      rpa1; replication factor-a protein 1 (rpa1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      60647185..60698279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767961.4XP_008766183.1  replication protein A 70 kDa DNA-binding subunit isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAT3
      Conserved Domains (3) summary
      cd04474
      Location:82184
      RPA1_DBD_A; RPA1_DBD_A: A subfamily of OB folds corresponding to the second OB fold, the ssDNA-binding domain (DBD)-A, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...
      pfam08646
      Location:357502
      Rep_fac-A_C; Replication factor-A C terminal domain
      pfam16900
      Location:201285
      REPA_OB_2; Replication protein A OB domain
    2. XM_063268676.1XP_063124746.1  replication protein A 70 kDa DNA-binding subunit isoform X2

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