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    Fbh1 F-box DNA helicase 1 [ Mus musculus (house mouse) ]

    Gene ID: 50755, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fbh1provided by MGI
    Official Full Name
    F-box DNA helicase 1provided by MGI
    Primary source
    MGI:MGI:1354699
    See related
    Ensembl:ENSMUSG00000058594 AllianceGenome:MGI:1354699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbx18; Fbxo18
    Summary
    Predicted to enable ATP-dependent activity, acting on DNA and DNA binding activity. Involved in negative regulation of double-strand break repair via homologous recombination and replication fork processing. Acts upstream of or within response to intra-S DNA damage checkpoint signaling. Predicted to be located in chromatin. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human FBH1 (F-box DNA helicase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 14.0), limb E14.5 (RPKM 13.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Fbh1 in Genome Data Viewer
    Location:
    2 A1; 2 9.01 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (11747384..11782396, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (11742573..11777585, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03677 Neighboring gene predicted gene, 39760 Neighboring gene predicted gene, 39759 Neighboring gene interleukin 15 receptor, alpha chain Neighboring gene predicted gene, 46731 Neighboring gene STARR-positive B cell enhancer ABC_E804 Neighboring gene ankyrin repeat domain 16 Neighboring gene STARR-seq mESC enhancer starr_03678 Neighboring gene STARR-seq mESC enhancer starr_03679 Neighboring gene predicted gene, 34768 Neighboring gene ankyrin repeat domain-containing protein 20A12 pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity  
    enables 3'-5' DNA helicase activity  
    enables 3'-5' DNA helicase activity  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP-dependent H2AZ histone chaperone activity  
    enables ATP-dependent H3-H4 histone complex chaperone activity  
    enables DNA clamp loader activity  
    enables DNA helicase activity  
    enables DNA translocase activity  
    enables chromatin extrusion motor activity  
    enables cohesin loader activity  
    enables double-stranded DNA binding  
    enables double-stranded DNA binding  
    enables double-stranded DNA helicase activity  
    enables forked DNA-dependent helicase activity  
    enables four-way junction helicase activity  
    enables isomerase activity  
    enables protein binding PubMed 
    enables single-stranded 3'-5' DNA helicase activity  
    enables single-stranded DNA binding  
    enables single-stranded DNA binding  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA catabolic process  
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in DNA duplex unwinding  
    involved_in DNA repair  
    involved_in chromatin looping  
    involved_in chromatin remodeling  
    involved_in double-strand break repair via homologous recombination  
    involved_in double-strand break repair via homologous recombination  
    acts_upstream_of_or_within negative regulation of chromatin binding PubMed 
    involved_in negative regulation of double-strand break repair via homologous recombination PubMed 
    involved_in negative regulation of double-strand break repair via homologous recombination  
    acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage  
    acts_upstream_of_or_within positive regulation of protein phosphorylation  
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    involved_in replication fork processing  
    involved_in replication fork processing PubMed 
    involved_in replication fork processing  
    acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling PubMed 
    acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex  
    part_of SCF ubiquitin ligase complex  
    located_in chromatin  
    located_in chromatin  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    F-box DNA helicase 1
    Names
    DNA 3'-5' helicase 1
    F-box only protein 18
    F-box protein 18
    NP_001335163.1
    NP_001335164.1
    NP_001335165.1
    NP_001335166.1
    NP_056607.1
    XP_006497568.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348234.1NP_001335163.1  F-box DNA helicase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL831794, AL845548
      UniProtKB/TrEMBL
      Q3UGP2
      Conserved Domains (2) summary
      COG0210
      Location:365857
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:136183
      F-box-like; F-box-like
    2. NM_001348235.1NP_001335164.1  F-box DNA helicase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL831794, AL845548
      UniProtKB/TrEMBL
      Q3UGP2
      Conserved Domains (2) summary
      COG0210
      Location:365857
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:136183
      F-box-like; F-box-like
    3. NM_001348236.1NP_001335165.1  F-box DNA helicase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL831794, AL845548
      UniProtKB/TrEMBL
      Q3UGP2
      Conserved Domains (2) summary
      COG0210
      Location:365857
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:136183
      F-box-like; F-box-like
    4. NM_001348237.1NP_001335166.1  F-box DNA helicase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK158937, AL831794, AL845548
      UniProtKB/TrEMBL
      Q3UGP2
      Conserved Domains (2) summary
      COG0210
      Location:365857
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:136183
      F-box-like; F-box-like
    5. NM_015792.2NP_056607.1  F-box DNA helicase 1 isoform 1

      See identical proteins and their annotated locations for NP_056607.1

      Status: VALIDATED

      Source sequence(s)
      AK003964, AK147829, AL831794, AL845548
      Consensus CDS
      CCDS15688.1
      UniProtKB/Swiss-Prot
      Q8C444, Q8K2I9, Q99KS0, Q9CTC6, Q9QZG7
      UniProtKB/TrEMBL
      Q3UGP2
      Related
      ENSMUSP00000071495.8, ENSMUST00000071564.14
      Conserved Domains (4) summary
      COG0210
      Location:439931
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:210259
      F-box-like; F-box-like
      pfam13538
      Location:870931
      UvrD_C_2; UvrD-like helicase C-terminal domain
      cl21455
      Location:440684
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      11747384..11782396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497505.3XP_006497568.1  F-box DNA helicase 1 isoform X1

      UniProtKB/TrEMBL
      Q3UGP2
      Conserved Domains (3) summary
      COG0210
      Location:439931
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      cd18786
      Location:835932
      SF1_C; C-terminal helicase domain of superfamily 1 DEAD/H-box helicases
      pfam12937
      Location:210257
      F-box-like
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