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    Psmb11 proteasome (prosome, macropain) subunit, beta type, 11 [ Mus musculus (house mouse) ]

    Gene ID: 73902, updated on 9-Dec-2024

    Summary

    Official Symbol
    Psmb11provided by MGI
    Official Full Name
    proteasome (prosome, macropain) subunit, beta type, 11provided by MGI
    Primary source
    MGI:MGI:1921152
    See related
    Ensembl:ENSMUSG00000072423 AllianceGenome:MGI:1921152
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    beta5t; 5830406J20Rik
    Summary
    Predicted to enable endopeptidase activity. Acts upstream of or within CD8-positive, alpha-beta T cell differentiation and T cell differentiation in thymus. Part of proteasome core complex. Is expressed in thymus and thymus cortex epithelium. Orthologous to human PSMB11 (proteasome subunit beta 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Psmb11 in Genome Data Viewer
    Location:
    14 C2; 14 27.87 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54862767..54867013)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54625310..54629556)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931414P19 gene Neighboring gene STARR-seq mESC enhancer starr_36743 Neighboring gene STARR-positive B cell enhancer ABC_E7314 Neighboring gene STARR-positive B cell enhancer mm9_chr14:55236824-55237125 Neighboring gene proteasome (prosome, macropain) subunit, beta type 5 Neighboring gene microRNA 686 Neighboring gene cadherin-like 24 Neighboring gene microRNA 6948 Neighboring gene apoptotic chromatin condensation inducer 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity  
    enables peptidase activity PubMed 
    enables protein binding PubMed 
    enables threonine-type endopeptidase activity  
    Component Evidence Code Pubs
    is_active_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    is_active_in nucleus  
    part_of proteasome core complex PubMed 
    part_of proteasome core complex, beta-subunit complex  
    part_of proteasome core complex, beta-subunit complex  

    General protein information

    Preferred Names
    proteasome subunit beta type-11
    Names
    proteasome beta 11 subunit
    proteasome subunit beta-5t
    proteasome subunit beta5t
    NP_780413.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175204.4NP_780413.1  proteasome subunit beta type-11

      See identical proteins and their annotated locations for NP_780413.1

      Status: VALIDATED

      Source sequence(s)
      AK162727, CT009512
      Consensus CDS
      CCDS49491.1
      UniProtKB/Swiss-Prot
      Q149K8, Q8BG41
      Related
      ENSMUSP00000132140.2, ENSMUST00000097177.5
      Conserved Domains (2) summary
      TIGR03690
      Location:48253
      20S_bact_beta; proteasome, beta subunit, bacterial type
      cd03761
      Location:50237
      proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      54862767..54867013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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