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    SYNGR3 synaptogyrin 3 [ Homo sapiens (human) ]

    Gene ID: 9143, updated on 10-Dec-2024

    Summary

    Official Symbol
    SYNGR3provided by HGNC
    Official Full Name
    synaptogyrin 3provided by HGNC
    Primary source
    HGNC:HGNC:11501
    See related
    Ensembl:ENSG00000127561 MIM:603927; AllianceGenome:HGNC:11501
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes an integral membrane protein. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it is a synaptic vesicle protein that also interacts with the dopamine transporter. The gene product belongs to the synaptogyrin gene family. [provided by RefSeq, Dec 2010]
    Expression
    Biased expression in brain (RPKM 26.0), adrenal (RPKM 4.5) and 2 other tissues See more
    Orthologs
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    Genomic context

    See SYNGR3 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1989970..1994275)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2009915..2014220)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2039971..2044276)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene transducin beta like 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2028593-2029172 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2029173-2029752 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr16:2029753-2030330 and GRCh37_chr16:2030331-2030910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10250 Neighboring gene NADPH oxidase organizer 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:2032733-2032925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7014 Neighboring gene growth factor, augmenter of liver regeneration Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2038929-2039508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7015 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7016 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7017 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2041827-2042404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2042985-2043562 Neighboring gene zinc finger protein 598, E3 ubiquitin ligase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7019 Neighboring gene Sharpr-MPRA regulatory region 7653 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2056701-2057648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7020 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2059548-2060496 Neighboring gene uncharacterized LOC124903626

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC20003

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH2 domain binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in membrane PubMed 
    is_active_in neuromuscular junction  
    located_in synaptic vesicle  
    is_active_in synaptic vesicle membrane  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004209.6NP_004200.2  synaptogyrin-3

      See identical proteins and their annotated locations for NP_004200.2

      Status: REVIEWED

      Source sequence(s)
      AC005606, BC014087
      Consensus CDS
      CCDS10456.1
      UniProtKB/Swiss-Prot
      B2R9S0, O43761
      Related
      ENSP00000248121.2, ENST00000248121.7
      Conserved Domains (1) summary
      pfam01284
      Location:20165
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      1989970..1994275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791799.1 Reference GRCh38.p14 PATCHES

      Range
      56118..60423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      2009915..2014220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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