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Adgrf1 adhesion G protein-coupled receptor F1 [ Mus musculus (house mouse) ]

Gene ID: 77596, updated on 9-Dec-2024

Summary

Official Symbol
Adgrf1provided by MGI
Official Full Name
adhesion G protein-coupled receptor F1provided by MGI
Primary source
MGI:MGI:1924846
See related
Ensembl:ENSMUSG00000041293 AllianceGenome:MGI:1924846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpr110; KPG_009; 5031409J19Rik
Summary
Enables G protein-coupled receptor activity. Acts upstream of or within several processes, including memory; nervous system development; and positive regulation of CREB transcription factor activity. Located in plasma membrane. Is expressed in adrenal gland; liver; and metanephros. Orthologous to human ADGRF1 (adhesion G protein-coupled receptor F1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in liver E18 (RPKM 3.1), liver adult (RPKM 1.6) and 4 other tissues See more
Orthologs
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Genomic context

See Adgrf1 in Genome Data Viewer
Location:
17 B3; 17 19.71 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (43581174..43636767)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (43270283..43325876)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130008D07 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:43369751-43370032 Neighboring gene predicted gene, 54007 Neighboring gene STARR-positive B cell enhancer mm9_chr17:43402088-43402388 Neighboring gene STARR-seq mESC enhancer starr_42590 Neighboring gene adhesion G protein-coupled receptor F5 Neighboring gene predicted gene, 25135 Neighboring gene STARR-seq mESC enhancer starr_42593 Neighboring gene STARR-seq mESC enhancer starr_42594 Neighboring gene meprin 1 alpha

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
involved_in cell surface receptor signaling pathway  
involved_in energy reserve metabolic process  
involved_in fat cell differentiation  
acts_upstream_of_or_within memory PubMed 
involved_in neuron projection development  
acts_upstream_of_or_within neuron projection development PubMed 
acts_upstream_of_or_within neuron projection development PubMed 
acts_upstream_of_or_within positive regulation of CREB transcription factor activity PubMed 
involved_in regulation of lipid metabolic process  
involved_in synapse assembly  
acts_upstream_of_or_within synapse assembly PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle  
is_active_in plasma membrane  
located_in plasma membrane PubMed 

General protein information

Preferred Names
adhesion G-protein coupled receptor F1
Names
G protein coupled receptor Gpr110
G-protein coupled receptor 110
internal gene name of KIRIN laboratory:M5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133776.3NP_598537.2  adhesion G-protein coupled receptor F1 precursor

    See identical proteins and their annotated locations for NP_598537.2

    Status: VALIDATED

    Source sequence(s)
    CT025700
    Consensus CDS
    CCDS28795.1
    UniProtKB/Swiss-Prot
    B0V2Q5, Q8BMV8, Q8VEC3
    Related
    ENSMUSP00000049380.6, ENSMUST00000047399.6
    Conserved Domains (4) summary
    smart00303
    Location:530571
    GPS; G-protein-coupled receptor proteolytic site domain
    cd14964
    Location:584607
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01390
    Location:153240
    SEA; SEA domain
    cl28897
    Location:584847
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    43581174..43636767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525120.4XP_006525183.1  adhesion G-protein coupled receptor F1 isoform X1

    Conserved Domains (4) summary
    smart00303
    Location:549590
    GPS; G-protein-coupled receptor proteolytic site domain
    cd14964
    Location:603626
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01390
    Location:172258
    SEA; SEA domain
    cl28897
    Location:603866
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_006525121.4XP_006525184.1  adhesion G-protein coupled receptor F1 isoform X2

    Conserved Domains (4) summary
    smart00303
    Location:548589
    GPS; G-protein-coupled receptor proteolytic site domain
    cd14964
    Location:602625
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01390
    Location:171257
    SEA; SEA domain
    cl28897
    Location:602865
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RNA

  1. XR_876591.3 RNA Sequence

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