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    Tank TRAF family member-associated Nf-kappa B activator [ Mus musculus (house mouse) ]

    Gene ID: 21353, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tankprovided by MGI
    Official Full Name
    TRAF family member-associated Nf-kappa B activatorprovided by MGI
    Primary source
    MGI:MGI:107676
    See related
    Ensembl:ENSMUSG00000064289 AllianceGenome:MGI:107676
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    I-TRAF; E430026L09Rik
    Summary
    Enables molecular function inhibitor activity. Involved in negative regulation of tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human TANK (TRAF family member associated NFKB activator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 6.0), frontal lobe adult (RPKM 5.6) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tank in Genome Data Viewer
    Location:
    2 C1.3; 2 35.56 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (61408901..61484515)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (61578557..61654171)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4455 Neighboring gene STARR-positive B cell enhancer ABC_E4456 Neighboring gene STARR-positive B cell enhancer mm9_chr2:61332470-61332771 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene predicted gene, 33841 Neighboring gene STARR-seq mESC enhancer starr_04631 Neighboring gene STARR-positive B cell enhancer ABC_E808 Neighboring gene STARR-positive B cell enhancer ABC_E5924 Neighboring gene STARR-positive B cell enhancer ABC_E506 Neighboring gene STARR-positive B cell enhancer ABC_E7821 Neighboring gene STARR-positive B cell enhancer mm9_chr2:61481154-61481454 Neighboring gene STARR-seq mESC enhancer starr_04632 Neighboring gene STARR-positive B cell enhancer ABC_E4457 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 Neighboring gene T-box brain transcription factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to cysteine-type deubiquitinase activity  
    contributes_to cysteine-type deubiquitinase activity  
    enables deubiquitinase activator activity  
    enables deubiquitinase activator activity  
    enables metal ion binding  
    enables molecular adaptor activity  
    enables molecular adaptor activity  
    enables molecular function inhibitor activity PubMed 
    enables protein binding PubMed 
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in cellular response to interleukin-1  
    involved_in cellular response to interleukin-1  
    involved_in cellular response to ionizing radiation  
    involved_in cellular response to ionizing radiation  
    involved_in cellular response to tumor necrosis factor  
    involved_in cellular response to tumor necrosis factor  
    involved_in negative regulation of canonical NF-kappaB signal transduction  
    involved_in negative regulation of canonical NF-kappaB signal transduction  
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway PubMed 
    involved_in positive regulation of protein deubiquitination  
    involved_in positive regulation of protein deubiquitination  
    involved_in positive regulation of type I interferon production  
    involved_in positive regulation of type I interferon production  
    involved_in positive regulation of ubiquitin-specific protease activity  
    involved_in positive regulation of ubiquitin-specific protease activity  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    part_of protein-containing complex  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    TRAF family member-associated NF-kappa-B activator
    Names
    TRAF-interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164071.1NP_001157543.1  TRAF family member-associated NF-kappa-B activator isoform 1

      See identical proteins and their annotated locations for NP_001157543.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 4 both encode the same isoform (1).
      Source sequence(s)
      AK147727, AL845291, BB660164
      Consensus CDS
      CCDS50592.1
      UniProtKB/TrEMBL
      Q3UGW0
      Related
      ENSMUSP00000108120.3, ENSMUST00000112501.9
      Conserved Domains (1) summary
      pfam12845
      Location:134185
      TBD; TBD domain
    2. NM_001164072.1NP_001157544.1  TRAF family member-associated NF-kappa-B activator isoform 2

      See identical proteins and their annotated locations for NP_001157544.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks one internal residue, compared to isoform 1.
      Source sequence(s)
      AK147727, AK165420, AL845291, BB660164
      Consensus CDS
      CCDS50593.1
      UniProtKB/TrEMBL
      Q3TNB4, Q8C2D3
      Related
      ENSMUSP00000108114.2, ENSMUST00000112495.8
      Conserved Domains (2) summary
      pfam05557
      Location:2583
      MAD; Mitotic checkpoint protein
      pfam12845
      Location:131184
      TBD; TBD domain
    3. NM_001355267.1NP_001342196.1  TRAF family member-associated NF-kappa-B activator isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 both encode the same isoform (1).
      Source sequence(s)
      AL845291, AL928859
      Consensus CDS
      CCDS50592.1
      UniProtKB/TrEMBL
      Q3UGW0
      Conserved Domains (1) summary
      pfam12845
      Location:134185
      TBD; TBD domain
    4. NM_001355268.1NP_001342197.1  TRAF family member-associated NF-kappa-B activator isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL845291, AL928859
      Related
      ENSMUST00000141544.8
      Conserved Domains (1) summary
      pfam12845
      Location:252
      TBD; TBD domain
    5. NM_001374667.1NP_001361596.1  TRAF family member-associated NF-kappa-B activator isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL845291, AL928859
      Consensus CDS
      CCDS89491.1
      UniProtKB/TrEMBL
      A2AR76, Q3TNB4
      Related
      ENSMUSP00000108121.2, ENSMUST00000112502.8
      Conserved Domains (2) summary
      pfam05557
      Location:59117
      MAD; Mitotic checkpoint protein
      pfam12845
      Location:165218
      TBD; TBD domain
    6. NM_001378922.1NP_001365851.1  TRAF family member-associated NF-kappa-B activator isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL845291, AL928859
      Conserved Domains (1) summary
      pfam12845
      Location:251
      TBD; TBD domain
    7. NM_011529.2NP_035659.1  TRAF family member-associated NF-kappa-B activator isoform 3

      See identical proteins and their annotated locations for NP_035659.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR and uses an upstream start codon, compared to variant 1. The resulting isoform (3) has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      AL845291, U59864
      Consensus CDS
      CCDS16061.1
      UniProtKB/Swiss-Prot
      P70347, Q61178
      UniProtKB/TrEMBL
      Q3UGW0
      Related
      ENSMUSP00000077219.3, ENSMUST00000078074.9
      Conserved Domains (1) summary
      pfam12845
      Location:166218
      TBD; TBD domain

    RNA

    1. NR_149323.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845291, AL928859
    2. NR_149324.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845291, AL928859

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      61408901..61484515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160230.1XP_036016123.1  TRAF family member-associated NF-kappa-B activator isoform X1

      UniProtKB/TrEMBL
      A2AR78
      Conserved Domains (1) summary
      pfam12845
      Location:166218
      TBD; TBD domain
    2. XM_036160231.1XP_036016124.1  TRAF family member-associated NF-kappa-B activator isoform X3

      UniProtKB/TrEMBL
      A2AR78
      Conserved Domains (1) summary
      pfam12845
      Location:132184
      TBD; TBD domain
    3. XM_036160232.1XP_036016125.1  TRAF family member-associated NF-kappa-B activator isoform X4

      UniProtKB/TrEMBL
      A2AR78
      Conserved Domains (1) summary
      pfam12845
      Location:131183
      TBD; TBD domain
    4. XM_017316913.3XP_017172402.1  TRAF family member-associated NF-kappa-B activator isoform X2

      UniProtKB/TrEMBL
      Q3TNB4, Q8C2D3
      Conserved Domains (2) summary
      pfam05557
      Location:2583
      MAD; Mitotic checkpoint protein
      pfam12845
      Location:131184
      TBD; TBD domain
    5. XM_036160236.1XP_036016129.1  TRAF family member-associated NF-kappa-B activator isoform X5

      Conserved Domains (1) summary
      pfam12845
      Location:251
      TBD; TBD domain
    6. XM_036160233.1XP_036016126.1  TRAF family member-associated NF-kappa-B activator isoform X5

      Conserved Domains (1) summary
      pfam12845
      Location:251
      TBD; TBD domain
    7. XM_036160237.1XP_036016130.1  TRAF family member-associated NF-kappa-B activator isoform X5

      Conserved Domains (1) summary
      pfam12845
      Location:251
      TBD; TBD domain
    8. XM_036160235.1XP_036016128.1  TRAF family member-associated NF-kappa-B activator isoform X5

      Conserved Domains (1) summary
      pfam12845
      Location:251
      TBD; TBD domain
    9. XM_036160234.1XP_036016127.1  TRAF family member-associated NF-kappa-B activator isoform X5

      Conserved Domains (1) summary
      pfam12845
      Location:251
      TBD; TBD domain

    RNA

    1. XR_866264.4 RNA Sequence

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