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Cbln2 cerebellin 2 precursor protein [ Mus musculus (house mouse) ]

Gene ID: 12405, updated on 9-Dec-2024

Summary

Official Symbol
Cbln2provided by MGI
Official Full Name
cerebellin 2 precursor proteinprovided by MGI
Primary source
MGI:MGI:88282
See related
Ensembl:ENSMUSG00000024647 AllianceGenome:MGI:88282
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A730004O05; 6330593N19Rik
Summary
The protein encoded by this gene belongs to a family of secreted neuronal glycoproteins. The transcript is broadly expressed in the embryonic and adult brain with higher levels in some regions including the olfactory bulb, thalamus, and cerebral cortex. The protein can bind to presynaptic neurexins and induce synaptogenesis in cultured neurons. Null mutant mice are viable, fertile and do not display obvious neuroanatomical defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Biased expression in CNS E18 (RPKM 8.2), whole brain E14.5 (RPKM 7.6) and 6 other tissues See more
Orthologs
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Genomic context

See Cbln2 in Genome Data Viewer
Location:
18 E4; 18 58.63 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (86727226..86736410)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (86711061..86718283)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25453 Neighboring gene predicted gene, 54041 Neighboring gene neuropilin (NRP) and tolloid (TLL)-like 1 Neighboring gene STARR-seq mESC enhancer starr_45283 Neighboring gene STARR-seq mESC enhancer starr_45284 Neighboring gene STARR-seq mESC enhancer starr_45285 Neighboring gene predicted gene, 46615 Neighboring gene DNA methyltransferase 1-associated protein 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in extracellular space PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in synapse  
is_active_in synaptic cleft PubMed 
located_in synaptic cleft PubMed 
is_active_in synaptic cleft PubMed 
is_active_in synaptic cleft PubMed 
part_of trans-synaptic protein complex PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302356.2NP_001289285.1  cerebellin-2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC115783
    Consensus CDS
    CCDS29388.1
    UniProtKB/Swiss-Prot
    Q8BGU2
    Related
    ENSMUSP00000068863.4, ENSMUST00000068423.10
    Conserved Domains (1) summary
    cl23878
    Location:86224
    C1q; C1q domain
  2. NM_001361142.1NP_001348071.1  cerebellin-2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC115783
    Consensus CDS
    CCDS29388.1
    UniProtKB/Swiss-Prot
    Q8BGU2
    Conserved Domains (1) summary
    cl23878
    Location:86224
    C1q; C1q domain
  3. NM_001361143.1NP_001348072.1  cerebellin-2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC115783
    Consensus CDS
    CCDS29388.1
    UniProtKB/Swiss-Prot
    Q8BGU2
    Conserved Domains (1) summary
    cl23878
    Location:86224
    C1q; C1q domain
  4. NM_001361144.1NP_001348073.1  cerebellin-2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC115783
    Consensus CDS
    CCDS29388.1
    UniProtKB/Swiss-Prot
    Q8BGU2
    Related
    ENSMUSP00000126810.2, ENSMUST00000169470.2
    Conserved Domains (1) summary
    cl23878
    Location:86224
    C1q; C1q domain
  5. NM_001361145.1NP_001348074.1  cerebellin-2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC115783
    Consensus CDS
    CCDS29388.1
    UniProtKB/Swiss-Prot
    Q8BGU2
    Conserved Domains (1) summary
    cl23878
    Location:86224
    C1q; C1q domain
  6. NM_172633.4NP_766221.1  cerebellin-2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC115783, AK032112, AK076174, BM948793, BX523565
    Consensus CDS
    CCDS29388.1
    UniProtKB/Swiss-Prot
    Q8BGU2
    Related
    ENSMUSP00000113695.2, ENSMUST00000122079.8
    Conserved Domains (1) summary
    cl23878
    Location:86224
    C1q; C1q domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    86727226..86736410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160955.1XP_036016848.1  cerebellin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BGU2
    Related
    ENSMUSP00000113996.2, ENSMUST00000122464.8
    Conserved Domains (1) summary
    cl23878
    Location:86224
    C1q; C1q domain
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