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    smrd-1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog [ Caenorhabditis elegans ]

    Gene ID: 176462, updated on 9-Dec-2024

    Summary

    Official Symbol
    smrd-1
    Official Full Name
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog
    Primary source
    WormBase:WBGene00010845
    Locus tag
    CELE_M03C11.8
    See related
    AllianceGenome:WB:WBGene00010845
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA binding activity; chromatin binding activity; and nucleosome array spacer activity. Predicted to be involved in DNA double-strand break processing; heterochromatin formation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in BASAN syndrome and adermatoglyphia. Orthologous to human SMARCAD1 (SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See smrd-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (10428327..10435988, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene BBS2_C domain-containing protein Neighboring gene U4/U6 small nuclear ribonucleoprotein Prp3 Neighboring gene ncRNA Neighboring gene ENhancer of Uncoordination Neighboring gene MLX-interacting protein;Ovule protein

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP-dependent chromatin remodeler activity  
    enables DNA binding  
    enables DNA binding  
    enables chromatin binding  
    enables helicase activity  
    enables hydrolase activity  
    enables nucleosome array spacer activity  
    Process Evidence Code Pubs
    involved_in DNA double-strand break processing  
    involved_in DNA repair  
    involved_in chromatin organization  
    involved_in chromatin remodeling  
    involved_in heterochromatin formation  
    involved_in positive regulation of transcription by RNA polymerase II  
    Component Evidence Code Pubs
    located_in chromatin  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog
    NP_499301.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10428327..10435988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066900.7NP_499301.2  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDG2
      Conserved Domains (3) summary
      cd00046
      Location:414556
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:397685
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:752866
      Helicase_C; Helicase conserved C-terminal domain
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