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Dusp12 dual specificity phosphatase 12 [ Mus musculus (house mouse) ]

Gene ID: 80915, updated on 9-Dec-2024

Summary

Official Symbol
Dusp12provided by MGI
Official Full Name
dual specificity phosphatase 12provided by MGI
Primary source
MGI:MGI:1890614
See related
Ensembl:ENSMUSG00000026659 AllianceGenome:MGI:1890614
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VH1; mVH1; ESTM36; T-DSP4; LMW-DSP4; 1190004O14Rik
Summary
Enables protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system and retina. Orthologous to human DUSP12 (dual specificity phosphatase 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 13.9), CNS E18 (RPKM 12.2) and 28 other tissues See more
Orthologs
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Genomic context

See Dusp12 in Genome Data Viewer
Location:
1 H3; 1 77.27 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170701756..170713109, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (170874187..170885540, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene activating transcription factor 6 Neighboring gene STARR-positive B cell enhancer ABC_E4381 Neighboring gene STARR-positive B cell enhancer ABC_E7774 Neighboring gene predicted gene, 29733 Neighboring gene STARR-positive B cell enhancer ABC_E7775 Neighboring gene STARR-positive B cell enhancer ABC_E5842 Neighboring gene STARR-seq mESC enhancer starr_02996 Neighboring gene predicted gene 9929 Neighboring gene STARR-seq mESC enhancer starr_02999 Neighboring gene STARR-positive B cell enhancer ABC_E7776 Neighboring gene STARR-positive B cell enhancer ABC_E5843 Neighboring gene STARR-positive B cell enhancer ABC_E11106 Neighboring gene STARR-positive B cell enhancer ABC_E4382 Neighboring gene STARR-positive B cell enhancer ABC_E4383 Neighboring gene STARR-positive B cell enhancer ABC_E3326 Neighboring gene Fc receptor-like B Neighboring gene Fc receptor-like A Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Gene trapped (1) 

Interactions

General gene information

Clone Names

  • MGC117646

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MAP kinase serine/threonine phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity  
enables calmodulin-dependent protein phosphatase activity  
enables histone H2AXS140 phosphatase activity  
enables histone H2AXY142 phosphatase activity  
enables kinase binding  
enables kinase binding  
enables myosin phosphatase activity  
enables non-membrane spanning protein tyrosine phosphatase activity  
enables phosphatase activity  
enables phosphoprotein phosphatase activity  
enables protein tyrosine phosphatase activity, metal-dependent  
enables protein tyrosine/serine/threonine phosphatase activity  
enables protein tyrosine/serine/threonine phosphatase activity PubMed 
enables protein tyrosine/serine/threonine phosphatase activity PubMed 
enables zinc ion binding  
enables zinc ion binding  
Component Evidence Code Pubs
located_in cytoplasm  
located_in cytoplasm  
located_in cytosol  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus  
located_in nucleus  

General protein information

Preferred Names
dual specificity protein phosphatase 12
Names
dual specificity phosphatase T-DSP4
dual specificity phosphatase VH1
NP_001343414.1
NP_001343415.1
NP_075662.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356485.1NP_001343414.1  dual specificity protein phosphatase 12 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113490
    Conserved Domains (1) summary
    cd00127
    Location:26165
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  2. NM_001356486.1NP_001343415.1  dual specificity protein phosphatase 12 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113490
    Conserved Domains (1) summary
    cl21483
    Location:140
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. NM_023173.2NP_075662.2  dual specificity protein phosphatase 12 isoform 1

    See identical proteins and their annotated locations for NP_075662.2

    Status: VALIDATED

    Source sequence(s)
    BC099453
    Consensus CDS
    CCDS15474.1
    UniProtKB/Swiss-Prot
    Q9D0T2, Q9EQD3
    UniProtKB/TrEMBL
    Q4KL39
    Related
    ENSMUSP00000027970.8, ENSMUST00000027970.14
    Conserved Domains (1) summary
    cd00127
    Location:26165
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RNA

  1. NR_151476.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113490
    Related
    ENSMUST00000046476.13
  2. NR_151477.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113490

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    170701756..170713109 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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