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wor worniu [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34906, updated on 17-Dec-2024

Summary

Official Symbol
worprovided by FlyBase
Official Full Name
worniuprovided by FlyBase
Primary source
FLYBASE:FBgn0001983
Locus tag
Dmel_CG4158
See related
AllianceGenome:FB:FBgn0001983
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS03023.1; br35; CG4158; Dmel\CG4158; l(2)35Da; l(2)br35; l35Da; Wor
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including nervous system development; positive regulation of transcription by RNA polymerase II; and regulation of neural precursor cell proliferation. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; ganglia; larval optic anlage; neuroblasts; and unpaired neurons. Used to study central nervous system cancer. Human ortholog(s) of this gene implicated in piebaldism. Orthologous to human SNAI2 (snail family transcriptional repressor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See wor in Genome Data Viewer
Location:
35D2-35D2; 2-51 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15423297..15425580, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15423297..15425580, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45374 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44861 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
is_active_in nucleus  

General protein information

Preferred Names
worniu
Names
CG4158-PA
D.m.Worniu
lethal(2)35Da
schnecke
warniu
wor-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    15423297..15425580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057253.4NP_476601.1  worniu [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476601.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXL3, Q9U7P8, Q9VJP2
    Related
    FBpp0080299
    Conserved Domains (5) summary
    PHA00732
    Location:379417
    PHA00732; hypothetical protein
    sd00017
    Location:408428
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:434456
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:421444
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:405482
    zf-C2H2_8; C2H2-type zinc ribbon
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