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DRG2 developmentally regulated GTP binding protein 2 [ Homo sapiens (human) ]

Gene ID: 1819, updated on 10-Dec-2024

Summary

Official Symbol
DRG2provided by HGNC
Official Full Name
developmentally regulated GTP binding protein 2provided by HGNC
Primary source
HGNC:HGNC:3030
See related
Ensembl:ENSG00000108591 MIM:602986; AllianceGenome:HGNC:3030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in ovary (RPKM 11.9), prostate (RPKM 10.9) and 25 other tissues See more
Orthologs
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Genomic context

See DRG2 in Genome Data Viewer
Location:
17p11.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (18087948..18107969)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (18034778..18054782)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (17991262..18011283)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene dynein regulatory complex subunit 3 Neighboring gene Sharpr-MPRA regulatory region 6800 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:17925691-17925854 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11823 Neighboring gene GID complex subunit 4 homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11824 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:17991145-17991646 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:17991647-17992146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18010366-18011013 Neighboring gene uncharacterized LOC105371566 Neighboring gene myosin XVA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18038431-18039424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18039425-18040418 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18045565-18046530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18046531-18047495 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124903944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18053522-18054022 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18056260-18056783

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding  
enables GTPase activity PubMed 
enables RNA binding PubMed 
enables membrane scission GTPase motor activity  
enables metal ion binding  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation  
involved_in signal transduction PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytosol  
located_in cytosol  
located_in intracellular membrane-bounded organelle  
located_in membrane PubMed 
located_in nucleoplasm  
located_in nucleus PubMed 

General protein information

Preferred Names
developmentally-regulated GTP-binding protein 2
Names
TRAFAC GTPase DRG2
translation factor GTPase DRG2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330144.2NP_001317073.1  developmentally-regulated GTP-binding protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC087164
    Consensus CDS
    CCDS82082.1
    UniProtKB/TrEMBL
    A8MZF9
    Related
    ENSP00000379076.4, ENST00000395726.8
    Conserved Domains (4) summary
    cd01896
    Location:63295
    DRG; Developmentally Regulated GTP-binding protein (DRG)
    COG1163
    Location:1331
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
    cl00155
    Location:289331
    UBQ; Ubiquitin-like proteins
    cl21455
    Location:3119
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001388.5NP_001379.1  developmentally-regulated GTP-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001379.1

    Status: REVIEWED

    Source sequence(s)
    BC000493, DA602486, X80754
    Consensus CDS
    CCDS11191.1
    UniProtKB/Swiss-Prot
    B2R8G5, P55039, Q53Y50, Q9BWB2
    Related
    ENSP00000225729.3, ENST00000225729.8
    Conserved Domains (4) summary
    cd01666
    Location:289363
    TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
    cd01896
    Location:63295
    DRG; Developmentally Regulated GTP-binding protein (DRG)
    COG1163
    Location:1364
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
    cl21455
    Location:3119
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    18087948..18107969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256499.4XP_005256556.1  developmentally-regulated GTP-binding protein 2 isoform X1

    Conserved Domains (4) summary
    cd01666
    Location:289384
    TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
    cd01896
    Location:63295
    DRG; Developmentally Regulated GTP-binding protein (DRG)
    COG1163
    Location:1385
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
    cl21455
    Location:3119
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_011523704.3XP_011522006.1  developmentally-regulated GTP-binding protein 2 isoform X2

    Conserved Domains (4) summary
    cd01896
    Location:63295
    DRG; Developmentally Regulated GTP-binding protein (DRG)
    COG1163
    Location:1352
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
    cl00155
    Location:289352
    UBQ; Ubiquitin-like proteins
    cl21455
    Location:3119
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_005256500.3XP_005256557.1  developmentally-regulated GTP-binding protein 2 isoform X3

    Conserved Domains (2) summary
    cd01666
    Location:208303
    TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
    cd01896
    Location:1214
    DRG; Developmentally Regulated GTP-binding protein (DRG)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    18034778..18054782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315305.1XP_054171280.1  developmentally-regulated GTP-binding protein 2 isoform X1

  2. XM_054315306.1XP_054171281.1  developmentally-regulated GTP-binding protein 2 isoform X2

  3. XM_054315307.1XP_054171282.1  developmentally-regulated GTP-binding protein 2 isoform X3

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