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Pon1 paraoxonase 1 [ Mus musculus (house mouse) ]

Gene ID: 18979, updated on 9-Dec-2024

Summary

Official Symbol
Pon1provided by MGI
Official Full Name
paraoxonase 1provided by MGI
Primary source
MGI:MGI:103295
See related
Ensembl:ENSMUSG00000002588 AllianceGenome:MGI:103295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pon
Summary
Enables arylesterase activity. Acts upstream of or within cholesterol metabolic process and response to toxic substance. Predicted to be part of spherical high-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to human PON1 (paraoxonase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in liver adult (RPKM 147.4), liver E18 (RPKM 50.7) and 1 other tissue See more
Orthologs
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Genomic context

See Pon1 in Genome Data Viewer
Location:
6 A1; 6 1.99 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (5168101..5193824, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (5168090..5193987, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 9A Neighboring gene predicted gene, 52886 Neighboring gene STARR-seq mESC enhancer starr_15032 Neighboring gene predicted gene, 46949 Neighboring gene STARR-seq mESC enhancer starr_15033 Neighboring gene paraoxonase 3 Neighboring gene STARR-positive B cell enhancer ABC_E3642 Neighboring gene paraoxonase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyl-L-homoserine-lactone lactonohydrolase activity  
enables acyl-L-homoserine-lactone lactonohydrolase activity  
enables aryldialkylphosphatase activity  
enables aryldialkylphosphatase activity  
enables aryldialkylphosphatase activity  
enables arylesterase activity  
enables arylesterase activity PubMed 
enables arylesterase activity  
enables arylesterase activity  
enables calcium ion binding  
enables calcium ion binding  
enables high-density lipoprotein particle binding PubMed 
enables phospholipid binding  
enables phospholipid binding  
enables protein homodimerization activity  
enables protein homodimerization activity  
Process Evidence Code Pubs
acts_upstream_of_or_within blood circulation PubMed 
involved_in carboxylic acid catabolic process  
involved_in carboxylic acid catabolic process  
acts_upstream_of_or_within cholesterol metabolic process PubMed 
acts_upstream_of_or_within cholesterol metabolic process PubMed 
involved_in lactone catabolic process  
involved_in lactone catabolic process  
involved_in organophosphate catabolic process  
involved_in organophosphate catabolic process  
involved_in phosphatidylcholine metabolic process  
involved_in phosphatidylcholine metabolic process  
involved_in positive regulation of cholesterol efflux  
involved_in positive regulation of cholesterol efflux  
involved_in response to fluoride  
involved_in response to toxic substance  
acts_upstream_of_or_within response to toxic substance PubMed 
involved_in response to toxic substance  
Component Evidence Code Pubs
is_active_in extracellular space  
located_in extracellular space  
part_of high-density lipoprotein particle  
part_of spherical high-density lipoprotein particle  
part_of spherical high-density lipoprotein particle  

General protein information

Preferred Names
serum paraoxonase/arylesterase 1
Names
A-esterase 1
PON 1
aromatic esterase 1
serum aryldialkylphosphatase 1
NP_001397188.1
NP_001397189.1
NP_001397190.1
NP_035264.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410259.1NP_001397188.1  serum paraoxonase/arylesterase 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC074225
  2. NM_001410260.1NP_001397189.1  serum paraoxonase/arylesterase 1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC074225
    UniProtKB/TrEMBL
    H3BK03
    Related
    ENSMUSP00000135195.3, ENSMUST00000177159.9
  3. NM_001410261.1NP_001397190.1  serum paraoxonase/arylesterase 1 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC074225
    UniProtKB/TrEMBL
    H3BK03
  4. NM_011134.4NP_035264.2  serum paraoxonase/arylesterase 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_035264.2

    Status: VALIDATED

    Source sequence(s)
    AC074225
    Consensus CDS
    CCDS19898.1
    UniProtKB/Swiss-Prot
    P52430, Q91X30
    Related
    ENSMUSP00000002663.6, ENSMUST00000002663.12
    Conserved Domains (1) summary
    pfam01731
    Location:168253
    Arylesterase; Arylesterase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    5168101..5193824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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