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pgp-1 Multidrug resistance protein pgp-1 [ Caenorhabditis elegans ]

Gene ID: 178215, updated on 9-Dec-2024

Summary

Official Symbol
pgp-1
Official Full Name
Multidrug resistance protein pgp-1
Primary source
WormBase:WBGene00003995
Locus tag
CELE_K08E7.9
See related
AllianceGenome:WB:WBGene00003995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in defense response to other organism; response to metal ion; and response to nematicide. Located in apical plasma membrane. Is expressed in intestine and pharynx. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cholestasis (multiple); drug dependence (multiple); and human immunodeficiency virus infectious disease (multiple). Orthologous to several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See pgp-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
14
Sequence:
Chromosome: IV; NC_003282.8 (12591704..12599169, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat domain-containing protein Neighboring gene Cullin-6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Lys Neighboring gene G-patch domain-containing protein Neighboring gene Exchange factor for Arf-6

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ABC-type transporter activity  
enables ABC-type xenobiotic transporter activity  
enables ATP binding  
enables ATP hydrolysis activity  
enables ATPase-coupled transmembrane transporter activity  
enables efflux transmembrane transporter activity  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium PubMed 
involved_in innate immune response PubMed 
involved_in response to chemical  
involved_in response to metal ion PubMed 
involved_in response to nematicide PubMed 
involved_in siderophore transmembrane transport  
involved_in siderophore-dependent iron import into cell  
involved_in transmembrane transport  
involved_in transmembrane transport  
involved_in xenobiotic transport  
Component Evidence Code Pubs
located_in apical plasma membrane PubMed 
is_active_in membrane  
located_in membrane  

General protein information

Preferred Names
Multidrug resistance protein pgp-1
NP_502413.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12591704..12599169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070012.6NP_502413.1  Multidrug resistance protein pgp-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502413.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34712, Q21349
    Conserved Domains (1) summary
    PTZ00265
    Location:381311
    PTZ00265; multidrug resistance protein (mdr1); Provisional
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