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Dcp2 decapping mRNA 2 [ Mus musculus (house mouse) ]

Gene ID: 70640, updated on 9-Dec-2024

Summary

Official Symbol
Dcp2provided by MGI
Official Full Name
decapping mRNA 2provided by MGI
Primary source
MGI:MGI:1917890
See related
Ensembl:ENSMUSG00000024472 AllianceGenome:MGI:1917890
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410015D23Rik; 5730537H01Rik
Summary
Predicted to enable 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity; 5'-3' RNA exonuclease activity; and telomerase RNA binding activity. Involved in mRNA catabolic process. Predicted to be located in cell junction; cytoplasmic ribonucleoprotein granule; and nucleoplasm. Predicted to be part of RISC complex. Predicted to be active in P-body. Is expressed in several structures, including eye; genitourinary system; liver; lung; and spleen. Orthologous to human DCP2 (decapping mRNA 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 8.4), cerebellum adult (RPKM 6.5) and 27 other tissues See more
Orthologs
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Genomic context

See Dcp2 in Genome Data Viewer
Location:
18 B3; 18 23.74 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (44513567..44558036)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (44380500..44424969)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41717 Neighboring gene STARR-seq mESC enhancer starr_44459 Neighboring gene STARR-seq mESC enhancer starr_44461 Neighboring gene STARR-positive B cell enhancer ABC_E9976 Neighboring gene myotilin Neighboring gene mutated in colorectal cancers Neighboring gene STARR-seq mESC enhancer starr_44470 Neighboring gene predicted gene, 52347 Neighboring gene STARR-seq mESC enhancer starr_44475 Neighboring gene STARR-seq mESC enhancer starr_44477 Neighboring gene RIKEN cDNA A930012L18 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity  
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity  
enables 5'-3' RNA exonuclease activity  
enables 5'-3' RNA exonuclease activity  
enables manganese ion binding  
enables telomerase RNA binding  
enables telomerase RNA binding  
Component Evidence Code Pubs
is_active_in P-body  
located_in P-body  
part_of RISC complex  
located_in cell junction  
located_in cell junction  
is_active_in cytoplasm  
located_in cytoplasmic ribonucleoprotein granule  
located_in nucleoplasm  
located_in nucleoplasm  

General protein information

Preferred Names
m7GpppN-mRNA hydrolase
Names
DCP2 decapping enzyme homolog
mRNA-decapping enzyme 2
NP_081766.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027490.1NP_081766.1  m7GpppN-mRNA hydrolase

    See identical proteins and their annotated locations for NP_081766.1

    Status: VALIDATED

    Source sequence(s)
    AC147551, AK153105, AK153310
    Consensus CDS
    CCDS50275.1
    UniProtKB/Swiss-Prot
    Q3TLD9, Q9CYC6
    UniProtKB/TrEMBL
    Q3U671
    Related
    ENSMUSP00000025350.9, ENSMUST00000025350.10
    Conserved Domains (2) summary
    cd03672
    Location:97246
    Dcp2p; mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical ...
    pfam05026
    Location:1294
    DCP2; Dcp2, box A domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    44513567..44558036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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