Replication interactions
Interaction |
Pubs |
HIV-1 NL4-3 replication requires GEMIN2 as replication is inhibited when GEMIN2 is deleted through CRISPR/Cas9 genome editing |
PubMed
|
Knockdown of gem (nuclear organelle) associated protein 2 (GEMIN2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells |
PubMed
|
Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Vpr
|
vpr
|
HIV-1 Vpr is identified to have a physical interaction with gem (nuclear organelle) associated protein 2 (GEMIN2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses |
PubMed
|
integrase
|
gag-pol
|
Tetramer formation of HIV-1 Integrase (IN) and its interaction with Gemin2 synergistically stimulate reverse transcriptase (RT) activity |
PubMed
|
|
gag-pol
|
The residues between 71 to 80 within the central core domain of HIV-1 IN are important for the interaction with SIP1 |
PubMed
|
|
gag-pol
|
Survival motor neuron (SMN)-interacting protein 1 (Gemin2) binds to the C-terminal domain (amino acids 213-288) of HIV-1 Integrase and facilitates efficient viral cDNA synthesis soon after infection |
PubMed
|
reverse transcriptase
|
gag-pol
|
Tetramer formation of HIV-1 Integrase (IN) and its interaction with Gemin2 synergistically stimulate reverse transcriptase (RT) activity |
PubMed
|
Go to the HIV-1, Human Interaction Database