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    Cyba cytochrome b-245, alpha polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 13057, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cybaprovided by MGI
    Official Full Name
    cytochrome b-245, alpha polypeptideprovided by MGI
    Primary source
    MGI:MGI:1316658
    See related
    Ensembl:ENSMUSG00000006519 AllianceGenome:MGI:1316658
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    b558; nmf333; p22phox; p22-phox
    Summary
    Predicted to enable SH3 domain binding activity; electron transfer activity; and protein heterodimerization activity. Predicted to contribute to superoxide-generating NAD(P)H oxidase activity. Involved in innate immune response. Acts upstream of or within positive regulation of mucus secretion; reactive oxygen species metabolic process; and regulation of release of sequestered calcium ion into cytosol. Located in endosome. Part of NADPH oxidase complex. Is expressed in several structures, including genitourinary system; hemolymphoid system; inner ear; limb; and liver. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma; chronic obstructive pulmonary disease; and phagocyte bactericidal dysfunction (multiple). Orthologous to human CYBA (cytochrome b-245 alpha chain). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney adult (RPKM 399.2), spleen adult (RPKM 288.4) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Cyba in Genome Data Viewer
    Location:
    8 E1; 8 71.04 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123151510..123159679, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122424771..122432940, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6698 Neighboring gene zinc finger CCCH-type containing 18 Neighboring gene interleukin 17C Neighboring gene STARR-positive B cell enhancer ABC_E9324 Neighboring gene STARR-positive B cell enhancer ABC_E8269 Neighboring gene STARR-positive B cell enhancer ABC_E1776 Neighboring gene predicted gene, 53466 Neighboring gene mevalonate (diphospho) decarboxylase Neighboring gene predicted gene, 51557

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding  
    enables SH3 domain binding  
    enables electron transfer activity  
    enables electron transfer activity  
    enables heme binding  
    enables metal ion binding  
    enables protein binding PubMed 
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables superoxide-generating NAD(P)H oxidase activity  
    contributes_to superoxide-generating NAD(P)H oxidase activity  
    Items 1 - 25 of 37
    Process Evidence Code Pubs
    involved_in cytochrome complex assembly  
    involved_in cytochrome complex assembly  
    acts_upstream_of establishment of localization in cell PubMed 
    involved_in hydrogen peroxide biosynthetic process  
    involved_in inflammatory response  
    involved_in inflammatory response  
    involved_in innate immune response PubMed 
    involved_in innate immune response  
    acts_upstream_of mucus secretion PubMed 
    involved_in negative regulation of glomerular filtration by angiotensin  
    involved_in positive regulation of blood pressure  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of defense response to bacterium  
    involved_in positive regulation of defense response to bacterium  
    involved_in positive regulation of endothelial cell proliferation  
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of interleukin-6 production  
    acts_upstream_of_or_within positive regulation of mucus secretion PubMed 
    involved_in positive regulation of phagocytosis  
    involved_in positive regulation of phagocytosis  
    involved_in positive regulation of reactive oxygen species biosynthetic process  
    involved_in positive regulation of reactive oxygen species biosynthetic process  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of superoxide anion generation  
    involved_in positive regulation of toll-like receptor 2 signaling pathway  
    involved_in positive regulation of toll-like receptor 2 signaling pathway  
    involved_in positive regulation of tumor necrosis factor production  
    involved_in positive regulation of tumor necrosis factor production  
    acts_upstream_of_or_within reactive oxygen species metabolic process PubMed 
    acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol PubMed 
    involved_in respiratory burst  
    involved_in respiratory burst  
    involved_in smooth muscle hypertrophy  
    involved_in superoxide anion generation  
    involved_in superoxide anion generation  
    involved_in superoxide anion generation  
    involved_in superoxide metabolic process  
    Items 1 - 25 of 37
    Component Evidence Code Pubs
    part_of NADPH oxidase complex  
    part_of NADPH oxidase complex PubMed 
    part_of NADPH oxidase complex  
    located_in apical plasma membrane  
    located_in cytoplasm PubMed 
    located_in dendrite  
    located_in endosome PubMed 
    located_in focal adhesion  
    located_in mitochondrion PubMed 
    located_in neuronal cell body  
    located_in perinuclear endoplasmic reticulum  
    located_in plasma membrane  
    located_in stress fiber  

    General protein information

    Preferred Names
    cytochrome b-245 light chain
    Names
    cytochrome b(558) alpha chain
    cytochrome b558 subunit alpha
    cytochrome beta-558
    neutrophil cytochrome b 22 kDa polypeptide
    p22 phagocyte B-cytochrome
    p22 phox
    superoxide-generating NADPH oxidase light chain subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301284.1NP_001288213.1  cytochrome b-245 light chain isoform 2

      See identical proteins and their annotated locations for NP_001288213.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to variant . The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK018713, AL591003, BC060635
      Consensus CDS
      CCDS85623.1
      UniProtKB/TrEMBL
      Q3TAM0
      Related
      ENSMUSP00000148320.2, ENSMUST00000212600.2
      Conserved Domains (1) summary
      pfam05038
      Location:9162
      Cytochrom_B558a; Cytochrome Cytochrome b558 alpha-subunit
    2. NM_007806.3NP_031832.2  cytochrome b-245 light chain isoform 1

      See identical proteins and their annotated locations for NP_031832.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK152414, BY005999, CF738398
      Consensus CDS
      CCDS22737.1
      UniProtKB/Swiss-Prot
      Q3U820, Q61462, Q9CWB9, Q9D2W2
      UniProtKB/TrEMBL
      B3VQI8, Q3TAM0
      Related
      ENSMUSP00000017604.9, ENSMUST00000017604.10
      Conserved Domains (1) summary
      pfam05038
      Location:9190
      Cytochrom_B558a; Cytochrome Cytochrome b558 alpha-subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      123151510..123159679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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